|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
These "new" functions of the CPEBs include regulating the balance between senescence and proliferation and its pathological manifestation, tumor development.
|
22542725 |
2012 |
|
Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
These changes observed in CPEB1 and CPEB3 might indicate regulatory functions of CPEBs in cancer development of HPV-positive and HPV-negative tumors, respectively, and the U6snRNA, GAPDH mRNA and CPEB1 mRNA levels may be useful as tumor markers for genital cancers although further investigations are needed.
|
19161537 |
2009 |
|
Glioma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
The main goal of this study was to evaluate the expression patterns of CPEB1 and CPEB4 in glioma patients.
|
27000226 |
2016 |
|
Glioma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Decreased expression of CPEB1 protein in gliomas correlated with the rising grade of tumor malignancy.
|
27256982 |
2016 |
|
Glioma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of CPEB1 decreased the number of GSCs in an orthotopically implanted glioma animal model.
|
25216517 |
2014 |
|
Glioma
|
0.040 |
Biomarker
|
disease |
BEFREE |
CPEB1 is also regulated directly by the tumor suppressor miR-101, a potential marker of glioma.
|
23788032 |
2013 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Overall, our findings suggest that the negative regulation between CPEB1 and SIRT1 contributes to the suppression of cancer stemness in HCC.
|
30237545 |
2018 |
|
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
MicroRNA-183 induces epithelial-mesenchymal transition and promotes endometrial cancer cell migration and invasion in by targeting CPEB1.
|
29923214 |
2018 |
|
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
miR‑454‑3p suppresses cell migration and invasion by targeting CPEB1 in human glioblastoma.
|
30106109 |
2018 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
Overall, our findings suggest that the negative regulation between CPEB1 and SIRT1 contributes to the suppression of cancer stemness in HCC.
|
30237545 |
2018 |
|
Malignant Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Decreased expression of CPEB1 protein in gliomas correlated with the rising grade of tumor malignancy.
|
27256982 |
2016 |
|
Primary malignant neoplasm
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Decreased expression of CPEB1 protein in gliomas correlated with the rising grade of tumor malignancy.
|
27256982 |
2016 |
|
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
It was also discovered that methylation of this site was significantly more prevalent in diffuse type GC (p=0.007) and in cases with lymph node metastases (p=0.042).In vitro, CPEB1 impaired invasion.
|
22052064 |
2012 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
These changes observed in CPEB1 and CPEB3 might indicate regulatory functions of CPEBs in cancer development of HPV-positive and HPV-negative tumors, respectively, and the U6snRNA, GAPDH mRNA and CPEB1 mRNA levels may be useful as tumor markers for genital cancers although further investigations are needed.
|
19161537 |
2009 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
These changes observed in CPEB1 and CPEB3 might indicate regulatory functions of CPEBs in cancer development of HPV-positive and HPV-negative tumors, respectively, and the U6snRNA, GAPDH mRNA and CPEB1 mRNA levels may be useful as tumor markers for genital cancers although further investigations are needed.
|
19161537 |
2009 |
|
Inflammatory pain
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Our previous studies have shown that CPEB1 knockdown in the amygdala exerts anxiolytic but not analgesic effects in a mouse model of inflammatory pain.
|
30731077 |
2019 |
|
Fragile X Syndrome
|
0.020 |
Biomarker
|
disease |
BEFREE |
CPEB1 is closely related to neuronal diseases, such as Fragile X Syndrome, learning and memory disorders, and chronic pain.
|
29242136 |
2018 |
|
Neoplasm Metastasis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Cytoplasmic polyadenylation element-binding protein 1 (CPEB1), a sequence-specific RNA-binding protein that regulates mRNA polyadenylation and translation, has been linked to cancer progression and metastasis.
|
30237545 |
2018 |
|
Tumor Progression
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Cytoplasmic polyadenylation element-binding protein 1 (CPEB1), a sequence-specific RNA-binding protein that regulates mRNA polyadenylation and translation, has been linked to cancer progression and metastasis.
|
30237545 |
2018 |
|
Inflammatory pain
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Anxiolytic effect of CPEB1 knockdown on the amygdala of a mouse model of inflammatory pain.
|
29242136 |
2018 |
|
Childhood Glioblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
miR‑454‑3p suppresses cell migration and invasion by targeting CPEB1 in human glioblastoma.
|
30106109 |
2018 |
|
Glioblastoma Multiforme
|
0.020 |
Biomarker
|
disease |
BEFREE |
miR‑454‑3p suppresses cell migration and invasion by targeting CPEB1 in human glioblastoma.
|
30106109 |
2018 |
|
Premature Menopause
|
0.020 |
Biomarker
|
disease |
BEFREE |
The importance of recently discovered hemizygous microdeletions of meiotic genes SYCE1 (10q26.3) and CPEB1 (15q25.2) in POF patients was also corroborated.
|
27301361 |
2016 |
|
Premature Menopause
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Deletion of CPEB1 Gene: A Rare but Recurrent Cause of Premature Ovarian Insufficiency.
|
27003306 |
2016 |
|
Neoplasm Metastasis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
These data suggest that at least in part, CPEB1 regulation of MMP9 mRNA expression mediates metastasis of breast cancer cells.
|
26411364 |
2016 |