|
Visual seizure
|
0.200 |
Biomarker
|
disease |
RGD |
Early increase of apoptosis-linked gene-2 interacting protein X in areas of kainate-induced neurodegeneration.
|
14751282 |
2004 |
|
Parkinson Disease
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
However, recently identified PD-linked genes, including DNAJC6 (auxilin), SYNJ1 (synaptojanin 1), and the PD risk gene SH3GL2 (endophilin A1), have also highlighted disruptions in synaptic vesicle endocytosis (SVE) as a significant contributor to disease pathogenesis.
|
30509690 |
2019 |
|
Parkinson Disease
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci.
|
28892059 |
2017 |
|
Parkinson Disease
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Detection and interpretation of shared genetic influences on 42 human traits.
|
27182965 |
2016 |
|
Parkinson Disease
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2.
|
22451204 |
2012 |
|
Parkinson Disease
|
0.110 |
GeneticVariation
|
disease |
GWASDB |
Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2.
|
22451204 |
2012 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
SH3GL2 (Src homology 3 (SH3) domain GRB2-like 2) is mainly expressed in the central nervous system and regarded as a tumour suppressor in human glioma.
|
28470949 |
2017 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
SH3GL2 and MFN2 expression was detected in sera exosomes of normal healthy women, but barely detectable in the majority of the women with breast cancer exhibiting SH3GL2 and MFN2 loss in their primary tumors.
|
26888829 |
2016 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
In accordance with higher frequency of methylation status in SH3GL2, statistical analysis showed methylation status of SH3GL2 was closely related to tumor TNM stage (P=0.003), but not related to age, tumor volume, tumor differentiation, lymph node metastasis and VIN grade.
|
26823912 |
2015 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
SH3GL2 is mainly distributed in the central nervous system and considered to be a tumor suppressor in many tumors.
|
24736727 |
2014 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Loss of Sh3gl2 was associated with increasing tumor grade and with muscle invasion, which is a reliable predictor of metastatic disease and cancer-derived mortality.
|
23814487 |
2013 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
We found significantly low (p = 0.0015) SH3GL2 protein expression in 71 % (43/60) primary tumors.
|
22968441 |
2013 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
The human Src homology 3 (SH3) domain GRB2-like 2 (SH3GL2) gene, a novel tumor suppressor gene in laryngeal squamous cell carcinoma (LSCC), induces apoptosis of tumor cells by regulating intra-cellular signal transduction networks.
|
20512084 |
2010 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
To understand the association of candidate tumour suppressor genes SH3GL2, p16(INK4a), p14(ARF), and p15(INK4b) in the pathogenesis of head and neck squamous cell carcinoma (HNSCC), we studied the deletion, mutation, and methylation of these genes in 61 dysplastic lesions and 94 HNSCC samples.
|
19023882 |
2009 |
|
Alzheimer's Disease
|
0.040 |
Biomarker
|
disease |
BEFREE |
Taken together, the present study suggests that the MEM/LINC00094/miR-224-5p (miR-497-5p)/Endophilin-1 axis plays a crucial role in the regulation of BBB permeability in AD microenvironment.
|
30801976 |
2019 |
|
Alzheimer's Disease
|
0.040 |
Biomarker
|
disease |
BEFREE |
Thus, a potential role for endophilin 1 in Aβ‑induced postsynaptic dysfunction has been identified, indicating a possible direction for the prevention of postsynaptic dysfunction in cognitive impairment and suggesting that endophilin may be a potential target for the clinical treatment of AD.
|
31059028 |
2019 |
|
Alzheimer's Disease
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Additionally, we previously showed that EP protein levels are elevated in AD patients and AD transgenic animal models.
|
30061577 |
2018 |
|
Glioblastoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Loss of SH3GL2 promotes the migration and invasion behaviours of glioblastoma cells through activating the STAT3/MMP2 signalling.
|
28470949 |
2017 |
|
Glioblastoma Multiforme
|
0.040 |
Biomarker
|
disease |
BEFREE |
Loss of SH3GL2 promotes the migration and invasion behaviours of glioblastoma cells through activating the STAT3/MMP2 signalling.
|
28470949 |
2017 |
|
Glioblastoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
We determined that RRM2 and COL3A1 were increased and directly correlated with glioma grade, while SH3GL2 and SNAP91 were decreased in GBM and inversely correlated with glioma grade.
|
27655637 |
2016 |
|
Glioblastoma Multiforme
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
We determined that RRM2 and COL3A1 were increased and directly correlated with glioma grade, while SH3GL2 and SNAP91 were decreased in GBM and inversely correlated with glioma grade.
|
27655637 |
2016 |
|
Glioblastoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
MiR-330-mediated regulation of SH3GL2 expression enhances malignant behaviors of glioblastoma stem cells by activating ERK and PI3K/AKT signaling pathways.
|
24736727 |
2014 |
|
Glioblastoma Multiforme
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
MiR-330-mediated regulation of SH3GL2 expression enhances malignant behaviors of glioblastoma stem cells by activating ERK and PI3K/AKT signaling pathways.
|
24736727 |
2014 |
|
Glioblastoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Collectively, these above-mentioned results suggest that miRNA-330 plays an oncogenic role in human glioblastoma by regulating SH3GL2 gene and might be a new therapeutic target of human glioblastoma.
|
23029364 |
2012 |
|
Glioblastoma Multiforme
|
0.040 |
Biomarker
|
disease |
BEFREE |
Collectively, these above-mentioned results suggest that miRNA-330 plays an oncogenic role in human glioblastoma by regulating SH3GL2 gene and might be a new therapeutic target of human glioblastoma.
|
23029364 |
2012 |