|
Coronary heart disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Relative to stable BP (-5 to 5 mmHg), a rise in SBP at least 15 mmHg and DBP at least 5 mmHg conferred 15 and 16% higher CVD risk; whereas the risk of CVD and CHD had 25 and 22% reduction with a decrease in SBP greater than15 mmHg, but not with DBP.
|
31116159 |
2019 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The logistic regression analysis also revealed the rs1799941 GG genotype was significantly associated with low SHBG in CHD patients.
|
31111369 |
2019 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To assess the association of prehypertension (SBP 120-139 mmHg and/or DBP 80-89 mmHg) and total cardiovascular diseases (CVDs), coronary heart disease (CHD), myocardial infarction (MI), and stroke.
|
31335511 |
2019 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Healthy middle-aged men had increased long-term risk of CHD with exercise SBP above 180 mmHg at moderate workload.
|
30325341 |
2019 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
OWCET was associated with an increased risk of both CVD [HR 1.25 (95% CI 1.02-1.52)] and CHD [HR 1.35 (95% CI 1.01-1.80)] events independently of traditional risk factors (age, sex, total cholesterol, HDL, cigarettes and BMI) including SBP.
|
29846329 |
2018 |
|
Coronary heart disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Risk of CHD and stroke increased significantly when SBP was above 125 mmHg or DBP above 72 mmHg in people without diabetes, whereas this trend was attenuated in diabetic patients.
|
29210861 |
2018 |
|
Coronary heart disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
HtgW phenotype distinguishes itself from the (virtually neutral) simple abdominal obesity in independently conferring high CHD risk when elevated or reduced SHBG levels interact.
|
27846754 |
2017 |
|
Coronary heart disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Based on a comparison of the highest versus lowest tertile models, the summary RRs (95% CIs) for CHD were 0.88 (0.63-1.23, I<sup>2 </sup>= 48.7%) for free testosterone, 1.16 (0.82-1.63, I<sup>2 </sup>= 47.8%) for estradiol, 0.98 (0.90-1.07, I<sup>2 </sup>= 3.2%) for sex hormone-binding globulin and 1.19 (0.89-1.58, I<sup>2 </sup>= 0) for dehydroepiandrosterone.
|
28326829 |
2017 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The importance of the (TAAAA)n alleles at the SHBG gene promoter for the severity of coronary artery disease in postmenopausal women.
|
18188141 |
2008 |
|
Coronary heart disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Among participants in the top 30% (ie, SBP increased on standing), a significantly larger proportion were black, mean seated SBP was higher, and the predicted risk of developing coronary heart disease after 8 years was greater.
|
10334798 |
1999 |