|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Fluorescence in situ hybridization (FISH) on metaphase chromosome spreads located the human BMI-1 gene to the short arm of chromosome 10 (10p13), a region known to be involved in translocations in various leukemias.
|
8268912 |
1993 |
|
Childhood Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The proto-oncogene bmi-1 is frequently activated by Moloney murine leukemia proviral insertions in E mu-myc transgenic mice1,2.
|
8268912 |
1993 |
|
B-Cell Lymphomas
|
0.040 |
Biomarker
|
group |
BEFREE |
Nucleotide sequence analysis of the cDNA clones demonstrates that flvi-2 encodes bmi-1, a gene previously identified as a target for MoMuLV integration and as a myc-collaborator in retrovirally-induced B-cell lymphomas in E mu-myc transgenic mice.
|
8390036 |
1993 |
|
Burkitt Lymphoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Using a mouse bmi-1 cDNA probe a transcript of 3.3 kb was detected on Northern blots of human Burkitt's lymphoma cell lines.
|
8268912 |
1993 |
|
Adult Burkitt Lymphoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Using a mouse bmi-1 cDNA probe a transcript of 3.3 kb was detected on Northern blots of human Burkitt's lymphoma cell lines.
|
8268912 |
1993 |
|
Childhood Burkitt Lymphoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Using a mouse bmi-1 cDNA probe a transcript of 3.3 kb was detected on Northern blots of human Burkitt's lymphoma cell lines.
|
8268912 |
1993 |
|
Acute Erythroblastic Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
We have isolated and sequenced cDNA clones from a human erythroleukemia cell line (K562) derived cDNA library, using different mouse bmi-1 cDNA fragments as a probe.
|
8268912 |
1993 |
|
Adult Erythroleukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
We have isolated and sequenced cDNA clones from a human erythroleukemia cell line (K562) derived cDNA library, using different mouse bmi-1 cDNA fragments as a probe.
|
8268912 |
1993 |
|
Erythroleukemia (Erythroid/Myeloid)
|
0.010 |
Biomarker
|
disease |
BEFREE |
We have isolated and sequenced cDNA clones from a human erythroleukemia cell line (K562) derived cDNA library, using different mouse bmi-1 cDNA fragments as a probe.
|
8268912 |
1993 |
|
Hodgkin Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
Because HRS cells are thought to originate from germinal center lymphocytes, these observations suggests that Hodgkin's disease is associated with coexpression of BMI-1 and EZH2 in HRS cells.
|
10980109 |
2000 |
|
Non-Small Cell Lung Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
It was the aim of this study to assess the expression of bmi-1 in resectable non-small cell lung cancer (NSCLC) in association with p16 and p14ARF (=human p19ARF).
|
11355949 |
2001 |
|
Lymphoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In mice, downregulation of one of the polycomb genes, bmi-1, leads to neurological alterations and severe proliferative defects in lymphoid cells, whilst bmi-1 overexpression, together with upregulation of myc-1, induces lymphoma.
|
11355949 |
2001 |
|
Lymphoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
A good correlation between BMI-1 mRNA levels and protein expression was observed in all types of lymphomas.
|
11289106 |
2001 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
These findings suggest that BMI-1 gene alterations in human neoplasms are uncommon, but they may contribute to the pathogenesis in a subset of malignant lymphomas, particularly of mantle cell type.
|
11289106 |
2001 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Tumours with moderate or strong bmi-1 expression were more likely to have low levels of p16 and p14ARF (P = 0.02).
|
11355949 |
2001 |
|
Carcinogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
The Bmi-1 protein that negatively regulates the p14ARF promoter and co-operates with c-myc in tumorigenesis was expressed at low to moderate levels in all BL analysed.
|
11360201 |
2001 |
|
Adult Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In mice, downregulation of one of the polycomb genes, bmi-1, leads to neurological alterations and severe proliferative defects in lymphoid cells, whilst bmi-1 overexpression, together with upregulation of myc-1, induces lymphoma.
|
11355949 |
2001 |
|
Childhood Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In mice, downregulation of one of the polycomb genes, bmi-1, leads to neurological alterations and severe proliferative defects in lymphoid cells, whilst bmi-1 overexpression, together with upregulation of myc-1, induces lymphoma.
|
11355949 |
2001 |
|
Mantle cell lymphoma
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
The four tumors with gene amplification showed significantly higher mRNA levels than other MCLs and NHLs with the BMI-1 gene in germline configuration.
|
11289106 |
2001 |
|
Mantle cell lymphoma
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
Also, BMI1 and RING1 continued to be expressed in proliferating MCL.
|
11298590 |
2001 |
|
Solid Neoplasm
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
The BMI-1 gene has been located on chromosome 10p13, a region involved in chromosomal translocations in infant leukemias, and amplified in occasional non-Hodgkin's lymphomas (NHLs) and solid tumors.
|
11289106 |
2001 |
|
Hematologic Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
BMI-1 gene amplification and overexpression in hematological malignancies occur mainly in mantle cell lymphomas.
|
11289106 |
2001 |
|
B-Cell Lymphomas
|
0.040 |
AlteredExpression
|
group |
BEFREE |
BMI-1 expression was significantly higher in chronic lymphocytic leukemia and MCL than in follicular lymphoma and large B cell lymphoma.
|
11289106 |
2001 |
|
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
BMI-1 gene amplification and overexpression in hematological malignancies occur mainly in mantle cell lymphomas.
|
11289106 |
2001 |
|
Burkitt Lymphoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The Bmi-1 protein that negatively regulates the p14ARF promoter and co-operates with c-myc in tumorigenesis was expressed at low to moderate levels in all BL analysed.
|
11360201 |
2001 |