Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia 		0.020 AlteredExpression disease BEFREE BMI-1 expression was significantly higher in chronic lymphocytic leukemia and MCL than in follicular lymphoma and large B cell lymphoma. 11289106 2001
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular 		0.020 AlteredExpression disease BEFREE BMI-1 expression was significantly higher in chronic lymphocytic leukemia and MCL than in follicular lymphoma and large B cell lymphoma. 11289106 2001
CUI: C0278764
Disease: Adult Burkitt Lymphoma
Adult Burkitt Lymphoma 		0.020 AlteredExpression disease BEFREE The Bmi-1 protein that negatively regulates the p14ARF promoter and co-operates with c-myc in tumorigenesis was expressed at low to moderate levels in all BL analysed. 11360201 2001
CUI: C0278879
Disease: Childhood Burkitt Lymphoma
Childhood Burkitt Lymphoma 		0.020 AlteredExpression disease BEFREE The Bmi-1 protein that negatively regulates the p14ARF promoter and co-operates with c-myc in tumorigenesis was expressed at low to moderate levels in all BL analysed. 11360201 2001
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.100 AlteredExpression disease BEFREE Furthermore, Bmi-1 was overexpressed in immortal MECs and several breast cancer cell lines. 12183433 2002
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.100 AlteredExpression disease BEFREE Furthermore, Bmi-1 was overexpressed in immortal MECs and several breast cancer cell lines. 12183433 2002
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression group BEFREE We report here that experimental induction of E2a-Pbx1 enhances expression of BMI-1, a lymphoid oncogene whose product functions as a transcriptional repressor of the INK4A-ARF tumor suppressor locus. 14536079 2003
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute 		0.050 AlteredExpression disease BEFREE We report here that experimental induction of E2a-Pbx1 enhances expression of BMI-1, a lymphoid oncogene whose product functions as a transcriptional repressor of the INK4A-ARF tumor suppressor locus. 14536079 2003
CUI: C0035436
Disease: Rheumatic Fever
Rheumatic Fever 		0.050 AlteredExpression disease BEFREE We report here that experimental induction of E2a-Pbx1 enhances expression of BMI-1, a lymphoid oncogene whose product functions as a transcriptional repressor of the INK4A-ARF tumor suppressor locus. 14536079 2003
CUI: C0264490
Disease: Acute respiratory failure
Acute respiratory failure 		0.050 AlteredExpression disease BEFREE We report here that experimental induction of E2a-Pbx1 enhances expression of BMI-1, a lymphoid oncogene whose product functions as a transcriptional repressor of the INK4A-ARF tumor suppressor locus. 14536079 2003
CUI: C0013264
Disease: Muscular Dystrophy, Duchenne
Muscular Dystrophy, Duchenne 		0.030 AlteredExpression disease BEFREE In contrast, the constitutive expression of telomerase and Bmi-1 in satellite cells from a control individual and from a patient suffering from Duchenne's muscular dystrophy yielded cell lines that remained diploid and conserved their growth factor dependence for proliferation. 14577914 2003
CUI: C0023448
Disease: Lymphoid leukemia
Lymphoid leukemia 		0.020 Biomarker disease BEFREE These results link E2a-Pbx1 with Bmi-1 on an oncogenic pathway that is likely to play a role in the pathogenesis of human lymphoid leukemias through downregulation of the INK4A-ARF gene. 14536079 2003
CUI: C0023448
Disease: Lymphoid leukemia
Lymphoid leukemia 		0.020 AlteredExpression disease LHGDN These results link E2a-Pbx1 with Bmi-1 on an oncogenic pathway that is likely to play a role in the pathogenesis of human lymphoid leukemias through downregulation of the INK4A-ARF gene. 14536079 2003
CUI: C0023418
Disease: leukemia
leukemia 		0.100 Biomarker disease BEFREE Overexpression of the polycomb group gene Bmi1 promotes cell proliferation and induces leukaemia through repression of Cdkn2a (also known as ink4a/Arf) tumour suppressors. 15029199 2004
CUI: C0025149
Disease: Medulloblastoma
Medulloblastoma 		0.100 AlteredExpression disease LHGDN Together with the rapid induction of Bmi1 expression on addition of Shh or on overexpression of the Shh target Gli1 in cerebellar granule cell cultures, these findings implicate BMI1 overexpression as an alternative or additive mechanism in the pathogenesis of medulloblastomas, and highlight a role for Bmi1-containing polycomb complexes in proliferation of cerebellar precursor cells. 15029199 2004
CUI: C0025149
Disease: Medulloblastoma
Medulloblastoma 		0.100 AlteredExpression disease BEFREE Together with the rapid induction of Bmi1 expression on addition of Shh or on overexpression of the Shh target Gli1 in cerebellar granule cell cultures, these findings implicate BMI1 overexpression as an alternative or additive mechanism in the pathogenesis of medulloblastomas, and highlight a role for Bmi1-containing polycomb complexes in proliferation of cerebellar precursor cells. 15029199 2004
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute 		0.050 Biomarker disease BEFREE Overexpression of the polycomb group gene Bmi1 promotes cell proliferation and induces leukaemia through repression of Cdkn2a (also known as ink4a/Arf) tumour suppressors. 15029199 2004
CUI: C0035436
Disease: Rheumatic Fever
Rheumatic Fever 		0.050 Biomarker disease BEFREE Overexpression of the polycomb group gene Bmi1 promotes cell proliferation and induces leukaemia through repression of Cdkn2a (also known as ink4a/Arf) tumour suppressors. 15029199 2004
CUI: C0264490
Disease: Acute respiratory failure
Acute respiratory failure 		0.050 Biomarker disease BEFREE Overexpression of the polycomb group gene Bmi1 promotes cell proliferation and induces leukaemia through repression of Cdkn2a (also known as ink4a/Arf) tumour suppressors. 15029199 2004
CUI: C0007097
Disease: Carcinoma
Carcinoma 		0.100 AlteredExpression group BEFREE Whereas normal bronchial epithelium was associated with widespread expression of BMI-1 in resting EZH2-negative cells, neoplastic cells in lung carcinomas displayed altered expression of both BMI-1 and EZH2. 15720799 2005
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.100 AlteredExpression disease BEFREE Two patterns of abnormal PcG expression were observed: increased expression of BMI-1 in dividing neoplastic cells of PLs and SCCs, and enhanced expression of EZH2 and Ki-67 in BMI-1-positive cells according to severity of the histopathologic stage. 15720799 2005
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.100 AlteredExpression disease BEFREE Nine (69%) SCC showed loss of p16 expression and 10 (77%) showed expression of BMI-1. 15892997 2005
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.100 AlteredExpression disease BEFREE Moderate to high BMI-1 expression was detected in AML patients, and the BMI-1 expression levels in AML samples were significantly higher than in normal bone marrow controls (P = .0011). 16105758 2005
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.100 AlteredExpression disease BEFREE The acquired karyotypic abnormalities and alterations including upregulation of Bmi-1 and telomerase all occur in acute myeloid leukemia (AML), establishing the relevance of this system. 16094415 2005
CUI: C0024299
Disease: Lymphoma
Lymphoma 		0.100 AlteredExpression group BEFREE Silencing of p16/INK4A expression is frequently caused by hyper-methylation of CpG islands in its promoter but may also be achieved through activation of Bmi-1, for example in lymphomas associated with the E2A-Pbx1 translocation. 15611658 2005