Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
With a cell-penetrating TAT-tag protein, B cell-specific Moloney murine leukemia virus integration site 1 (BMI1), a robust glioma stem-cell marker, is found to mediate the effect of USP22 on glioma stemness.
|
29788550 |
2018 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Taken together, the present study suggests that miR-194 inhibits glioma cell EMT by targeting Bmi1 providing novel insights into understanding the pathogenesis of glioma.
|
28098896 |
2017 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The HK2 expression in (a) lentivirus-infected, miR-218 overexpressing and (b) shRNA mediated Bmi1 silenced U87 and U251 glioma cell lines were quantified.
|
29220380 |
2017 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this work, we found that Shh-Gli1 signaling regulates the expression of one stem cell marker, BMI1 (B cell-specific Moloney murine leukemia virus), in glioma.
|
27662839 |
2016 |
Glioma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Together, this is the first study to show that the inhibition of Bcl11b suppresses glioma cell growth by regulating the expression of the cell cycle regulator p21 and stemness-associated genes (Sox-2/Bmi-1).
|
26096706 |
2016 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings suggest that the IDH1R132H‑HIF‑1α‑miR‑128a‑Bmi‑1 pathway is involved in glioma cell proliferation.
|
26324126 |
2015 |
Glioma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The BMI1 mRNA in glioma was remarkably up-regulated, 176.3% as much as that in peri-cancerous tissues (P<0.05).
|
25858624 |
2015 |
Glioma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Reduction in glioma cell invasion due to downregulation of Bmi-1 could be rescued by p16 downregulation.
|
25262972 |
2015 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Taken together, these findings suggest that Bmi-1 promotes glioma cell migration and invasion via NF-κB-mediated upregulation of MMP-3.
|
25252846 |
2014 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In summary, we identified the over-expressed BMI1 as a promising therapeutic target for glioma stem cells, and suggest that the signaling pathways associated with activated BMI1 in promoting tumor growth may be different from those induced by silencing BMI1 in blocking tumor formation.
|
25526772 |
2014 |
Glioma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Together, our data suggest that Bmi-1 plays an important role in glioma angiogenesis and therefore could represent a potential target for anti-angiogenic therapy against the disease.
|
23383216 |
2013 |
Glioma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
MiR-128 and SUZ12/BMI1 show opposite expression in human glioblastomas versus normal brain and in glioma stemlike versus neural stem cells.
|
23733246 |
2013 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We documented that miR-218 also blocked the self-renewal of glioma stem-like cells, consistent with the suggested role of Bmi1 in stem cell growth.
|
23950210 |
2013 |
Glioma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Both Bmi1 and EZH2 expressions in glioma tissues were significantly higher than those in corresponding nonneoplastic brain tissues (both P<0.001).
|
24139839 |
2013 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Together, our data suggest that Bmi-1 plays an important role in glioma angiogenesis and therefore could represent a potential target for anti-angiogenic therapy against the disease.
|
23383216 |
2013 |
Glioma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A172 and LN229 glioma cells were engineered to overexpress Bmi-1 via stable transfection or to be silenced for Bmi-1 expression using RNA interfering method.
|
22967049 |
2012 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Cellular depletion of Bmi-1 enhances the sensitivity of glioma cells to apoptosis induced by doxorubicin, BCNU, or UV irradiation.
|
20035051 |
2010 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our data suggests that down-regulation of miRNA-128 may contribute to glioma and GBM, in part, by coordinately up-regulating ARP5 (ANGPTL6), Bmi-1 and E2F-3a, resulting in the proliferation of undifferentiated GBM cells.
|
19941032 |
2010 |
Glioma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
This showed that miR-128 specifically blocked glioma self-renewal consistent with Bmi-1 down-regulation.
|
19010882 |
2008 |
Glioma
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Of all gliomas, 59% demonstrated aberrant copy numbers of BMI1.
|
18427816 |
2008 |
Glioma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
This data suggests that BMI1 gene is aberrant at the chromosomal level in a subset of gliomas, and possibly contributes to brain tumour pathogenesis.
|
18427816 |
2008 |