Medulloblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this work, we describe the epigenetic regulator BMI1 as a novel therapeutic target for the treatment of recurrent human Group 3 MB, a childhood brain tumor for which there is virtually no treatment option beyond palliation.
|
30348991 |
2019 |
Medulloblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To further clarify the effects of ECs on the formation of MB stem-like cells, the expression of genes and protein in MB stem-like cells (CCND1, CDK6, c-MYC, and Bmi-1) and Notch (Notch2, Jagged 1, Hes-1, and Hey-2) was quantified by quantitative real-time PCR (qRT-PCR) and western blot, respectively.
|
28856557 |
2017 |
Medulloblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings extend current knowledge of the role of BMI1 and CHD7 in medulloblastoma pathogenesis, and they raise the possibility that pharmacological targeting of BMI1 or ERK may be particularly indicated in a subgroup of MB with low expression levels of CHD7.
|
29212025 |
2017 |
Medulloblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here we demonstrate that human medulloblastoma of Group 4 characterised by the greatest overexpression of BMI1, also display deregulation of cell adhesion molecules.
|
24460684 |
2014 |
Medulloblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We assessed the functional relevance of two genes, FoxG1 and Bmi1, which were significantly enriched in non-Shh/Wnt MBs and showed these genes to mediate MB stem cell self-renewal and tumor initiation in mice.
|
23592496 |
2013 |
Medulloblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Importantly, Bmi1 overexpression at the GCP stage does not induce tumour formation, suggesting that BMI1 overexpression in GCP-derived human medulloblastomas probably occurs during later stages of oncogenesis and might serve to enhance tumour cell survival.
|
23065639 |
2013 |
Medulloblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings implicate Bmi1 and Hh as mutually indispensable pathways in medulloblastoma BTIC maintenance.
|
21685941 |
2012 |
Medulloblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Combined transgenic expression of Bmi1 together with conditional loss of Rb resulted in pituitary tumors but was insufficient to induce medulloblastoma therefore indicating that the oncogenic function of Bmi1 depends on regulation of p16(INK4A)/Rb rather than on regulation of p19(ARF)/p53.
|
22574128 |
2012 |
Medulloblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our analysis showed correlation between BMI1 and PCGF2 gene's expression and survival in children with medulloblastoma.
|
20717685 |
2011 |
Medulloblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We demonstrate that miR-128a has growth suppressive activity in medulloblastoma and that this activity is partially mediated by targeting Bmi-1.
|
20574517 |
2010 |
Medulloblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We report here that short hairpin RNA-mediated knockdown of either Bmi-1 or Mel-18 in human medulloblastoma DAOY cells results in the inhibition of proliferation, loss of clonogenic survival, anchorage-independent growth, and suppression of tumor formation in nude mice.
|
17452456 |
2007 |
Medulloblastoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Together with the rapid induction of Bmi1 expression on addition of Shh or on overexpression of the Shh target Gli1 in cerebellar granule cell cultures, these findings implicate BMI1 overexpression as an alternative or additive mechanism in the pathogenesis of medulloblastomas, and highlight a role for Bmi1-containing polycomb complexes in proliferation of cerebellar precursor cells.
|
15029199 |
2004 |
Medulloblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Together with the rapid induction of Bmi1 expression on addition of Shh or on overexpression of the Shh target Gli1 in cerebellar granule cell cultures, these findings implicate BMI1 overexpression as an alternative or additive mechanism in the pathogenesis of medulloblastomas, and highlight a role for Bmi1-containing polycomb complexes in proliferation of cerebellar precursor cells.
|
15029199 |
2004 |