|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our findings elucidate the molecular mechanism underlying hepatic Bmi1-driven carcinogenesis and highlight the importance of TGFβ2 as a tumour suppressor in HCC development.
|
31591477 |
2020 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
BMI1 represses tumor suppressors to promote cell proliferation, epithelial-mesenchymal transition (EMT), and cancer progression.
|
31462713 |
2020 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Bmi-1 is also an oncogene promoting malignance of tumor and an anti-cancer target in many studies.
|
31669557 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The western blot measurement of apoptosis-protein and cancer stem cell (CSC) marked-protein demonstrated that UA led to activation-induced tumor cell death and Bmi1 siRNA resulted in inhibition of cancer stem cells.
|
31366257 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Overexpression of Bmi1 resulted in significantly attenuated tumor formation and tumor sphere formation.
|
31173263 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
BMI1 overexpression downregulates the expression of tumor suppressor genes, such as p16Ink4a and PTEN.
|
31079965 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Remarkably, the BMI1 inhibitor has therapeutic effects in cisplatin-resistant tumors and can reduce metastases initiated by circulating CSCs.
|
30936460 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, multipotency, karyotype, and tumour formation in nude mice of SHED and SHED-Bmi1-EGFP were also tested.
|
30984268 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
<b>Methods:</b> Here, we investigated the impact of PTC-209, a small-molecule Bmi-1 inhibitor, on human cancer cell viability alone and in combination with anticancer drugs, namely, cisplatin, oxaliplatin, 5-fluorouracil, camptothecin, and Frondoside-A and its impact on cellular migration and colony growth <i>in vitro</i> and on tumor growth <i>in ovo</i>.
|
31695609 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In conclusion, paclitaxel has a stronger suppressive effect on tumor growth and proliferation in CRC with low BMI1 expression.
|
31815052 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Expression of Bmi-1 protein in gallbladder carcinoma was correlated with tumor differentiation and stage (P<0.05).
|
31423199 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Human papillomavirus- and p16-positive tumors expressed less Bmi-1 and more HESC5:3 than the negative tumors.
|
30915904 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In conclusion, the mPEG-CS nano-carrier is an ideal vector in gene therapy, while silencing the Bmi-1 gene can enhance the sensitivity of CD133+ tumor stem cells to chemoradiotherapy and abate their invasion ability.
|
29448632 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
BMI-1 mRNA and positive protein levels were correlated with the National Institutes of Health (NIH) risk grade, tumor diameter and infiltration, and metastasis.
|
30209248 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Functional and pathway enrichment analysis showed that most of BMI1's coexpressed genes were involved in tumor growth-related process, such as regulation of cell cycle and proliferation.
|
29486292 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, miR-302 also silences BMI-1, a cancer stem cell gene marker, to promote the expression of two senescence-associated tumor suppressor genes, p16Ink4a and p14/p19Arf.
|
29435940 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Xenograft tumor studies confirmed that overexpression of miR-452 suppressed tumor growth in nude mice and reduced the expression of BMI1.
|
29326345 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
And Chromatin Immunoprecipitation assay confirms that the derepressed tumor suppressor genes belong to BMI-1 targets and the enrichment levels of H2AK119ub1 at their promoters is decreased upon PTC-209 treatment.
|
29886801 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In addition, BMI-1 was positively related to tumour size and lymph node metastases and negatively to the overall survival of ESCC patients.
|
29207170 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
More importantly, we demonstrate that targeting BMI1 effectively inhibits tumor growth of xenografts that have developed resistance to surgical castration and enzalutamide treatment.
|
29402932 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tamoxifen significantly reduced the growth of xenografts derived from MCF7 cells, but accelerated the growth of tumors produced by BMI1 overexpressing MCF7 cells.
|
29626519 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
PTC596 effectively decreased BMI-1-expressing and tumor-initiating side population MCL cells (IC<sub>50</sub>: 138 nM) compared with ibrutinib, which modestly decreased side population cells.
|
29983879 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We also show that TA-III induces expression of tumor suppressive miR-200c and miR-141, which are negatively regulated by BMI1.
|
29528145 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Thus, inhibition of BMI1 expression particularly in breast cancer stem cells can be used as a potential strategy for the complete elimination of tumor and to prevent disease relapse.
|
30096458 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Mechanistic studies identified that BMI1 served as the direct target of miR-141, and overexpression of BMI1 reversed the tumor repressor effect of miR-141.
|
30405786 |
2018 |