Childhood Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This was accompanied by a reduction of expression of the B lymphoma Moloney murine leukemia virus (Mo-MLV) insertion region 1 (Bmi1) at both gene and protein levels.
|
31725940 |
2020 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Western blot analyses revealed strong HCMV-mediated upregulation of RING finger protein 1B (RING1B) and B lymphoma Moloney murine leukemia virus insertion region 1 homolog (BMI1) as well as of enhancer of zeste homolog 2 (EZH2), suppressor of zeste 12 (SUZ12), and embryonic ectoderm development (EED), which constitute the core components of PRC1 and PRC2, respectively.
|
30814291 |
2019 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
B-lymphoma Moloney murine leukemia virus insertion region-1 (BMI-1) was confirmed to be a direct target for miR-218 and upregulated in LA tissues, which indicated the poor prognosis of LA patients.
|
31599423 |
2019 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We identified B lymphoma Mo-MLV insertion region l homolog (BMI1) as a downstream target regulated by miR-15b/DCLK1 signaling.
|
30449704 |
2018 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Polycomb group (PcG) proteinB lymphoma Mo-MLV insertion region 1 homolog (BMI1) is a transcriptional repressor that plays an important role in human carcinogenesis.
|
29394261 |
2018 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The B-lymphoma Moloney murine leukemia virus insertion region-1 protein (BMI1) acts as an oncogene in various cancers, including breast cancer.
|
28655885 |
2017 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The importance of B-lymphoma Moloney murine leukemia virus insertion region-1 (BMI-1) was implicated in cell proliferation, stem cell maintenance, and tumor initiation.
|
28270035 |
2017 |
Childhood Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A significant higher expression of B-lymphoma Moloney murine leukemia virus insertion region-1 (Bmi-1) has been reported in cell lines from metastatic melanoma compared to cell lines from primary melanoma.
|
27878257 |
2017 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The polycomb group family member B-lymphoma Moloney murine leukemia virus insertion region-1 (Bmi1) is overexpressed and involved in cancer progression in PDAC; however, its role in the multistep malignant transformation of human pancreatic duct cells has not been directly demonstrated.
|
26951514 |
2016 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
BITC treatment resulted in a marked decrease in protein level of polycomb group protein B-lymphoma Moloney murine leukemia virus insertion region-1 (Bmi-1) in cultured human breast cancer cells (MCF-7, SUM159, MDA-MB-231, and MDA-MB-361) and MDA-MB-231 xenografts in vivo.
|
25663545 |
2015 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
On screening for upstream regulators of BMI1, we found that expression of microRNA-16 (miR-16) was downregulated in MCL SP cells by regulating Bmi1 in the SPs, leading to reductions in tumor size following lymphoma xenografts.
|
23686310 |
2014 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
BMI1, the polycomb-group gene, is recurrently targeted by genomic rearrangements in progressive B-cell leukemia/lymphoma.
|
23873701 |
2013 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
B-lymphoma mouse Moloney leukemia virus insertion region 1 (Bmi1), a member of the polycomb group, has elevated expression and is involved in the pathogenesis of various aggressive cancers, including nasopharyngeal carcinoma (NPC).
|
23601184 |
2013 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Oncogenic Bmi-1 (B-lymphoma Moloney murine leukemia virus insertion region-1) belongs to the Polycomb-group (PcG) family of proteins and plays an important role in the regulation of proliferation, senescence, cell cycle and apoptosis, chromosome stability, activation of gene transcription.
|
22994774 |
2012 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
B-lymphoma Moloney murine leukemia virus insertion region-1 (Bmi-1) acts as an oncogene in various tumors, and its overexpression correlates with a poor outcome in several human cancers.
|
21276221 |
2011 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, overexpression of the PcG protein, Bmi-1, causes lymphoma in transgenic mice.
|
17148591 |
2007 |
Childhood Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In mice, downregulation of one of the polycomb genes, bmi-1, leads to neurological alterations and severe proliferative defects in lymphoid cells, whilst bmi-1 overexpression, together with upregulation of myc-1, induces lymphoma.
|
11355949 |
2001 |