SIX1, SIX homeobox 1, 6495

N. diseases: 200; N. variants: 12
Disease: Glaucoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017601
Disease: Glaucoma
Glaucoma 		0.030 Biomarker disease BEFREE SIX1 and SIX6 are glaucoma susceptibility genes. 28663559 2017
CUI: C0017601
Disease: Glaucoma
Glaucoma 		0.030 Biomarker disease BEFREE Our study was unable to confirm previous associations reported for variants in CDKN2B-AS1, CDKN2B, and SIX1 with any type of glaucoma. 25489222 2014
CUI: C0017601
Disease: Glaucoma
Glaucoma 		0.030 GeneticVariation disease BEFREE Of the eight loci, we found significant evidence (P= 1.41 × 10(-8)) for the association of CDKN2B with glaucoma [odds ratio (OR) for those homozygous for the risk allele: 0.76; 95% confidence interval (CI): 0.70-0.84], for the role of ATOH7 (OR: 1.28; 95% CI: 1.12-1.47) and for SIX1 (OR: 1.20; 95% CI: 1.10-1.31) when adjusting for the number of tested loci. 21427129 2011