SIX1, SIX homeobox 1, 6495

N. diseases: 200; N. variants: 12
Disease: Low Tension Glaucoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0152136
Disease: Low Tension Glaucoma
Low Tension Glaucoma 		0.030 GeneticVariation disease BEFREE In the subgroup analysis of HTG and NTG, multiple variants at CDKN2B-AS1 and SIX1/SIX6 showed stronger association with NTG than HTG. 25711633 2015
CUI: C0152136
Disease: Low Tension Glaucoma
Low Tension Glaucoma 		0.030 GeneticVariation disease BEFREE Japanese patients with NTG (n = 213) and HTG (n = 212) and 191 control subjects were genotyped for 5 non-IOP-related genetic variants predisposing to POAG near the SRBD1, ELOVL5, CDKN2B/CDKN2B-AS1, SIX1/SIX6, and ATOH7 genes. 25461262 2015
CUI: C0152136
Disease: Low Tension Glaucoma
Low Tension Glaucoma 		0.030 GeneticVariation disease BEFREE Ages at diagnosis were significantly different in the NTG subjects with and without the rs10483727 (SIX1) C allele (P = 0.017) or the rs1926320 (DCLK1) T allele (P = 0.040). 22584021 2012