PINK1, PTEN induced kinase 1, 65018

N. diseases: 209; N. variants: 39
Disease: Heart failure ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0018801
Disease: Heart failure
Heart failure 		0.030 AlteredExpression disease BEFREE The mRNA and protein levels of pink1, parkin, p62, and LC3 indicated that excessive mitophagy was observed in the rat model of advanced heart failure. 30416661 2018
CUI: C0018801
Disease: Heart failure
Heart failure 		0.030 Biomarker disease BEFREE The results show that phosphorylation of Ser495 in PINK1 by AMPKα2 was essential for efficient mitophagy to prevent the progression of HF. 29284690 2018
CUI: C0018801
Disease: Heart failure
Heart failure 		0.030 AlteredExpression disease BEFREE Here, we observed that PINK1 protein levels are markedly reduced in end-stage human HF. 21606348 2011