PINK1, PTEN induced kinase 1, 65018

N. diseases: 209; N. variants: 39
Disease: Kidney Failure, Acute ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute 		0.050 Biomarker disease BEFREE PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation. 31229841 2019
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute 		0.050 Biomarker disease BEFREE PINK1 Deficiency Ameliorates Cisplatin-Induced Acute Kidney Injury in Rats. 31607953 2019
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute 		0.050 Biomarker disease BEFREE Here we investigated whether the PINK1-Parkin mitophagy pathway is involved in septic AKI and its effects on cell apoptosis in vitro and on renal functions in vivo. 31567378 2019
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute 		0.050 Biomarker disease BEFREE Taken together, these results indicate that PINK1-PARK2-mediated mitophagy plays an important role in mitochondrial quality control, tubular cell survival, and renal function during AKI. 29172924 2018
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute 		0.050 Biomarker disease BEFREE Our results provide clear evidence that Pink1/Parkin-dependent mitophagy has identified potential targets for the treatment of cisplatin-induced AKI. 28024839 2017