Parkinson Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Loss-of-function of PINK1/Parkin-mediated mitophagy results in the accumulation of dysfunctional mitochondria, which could be one etiology of Parkinson's disease (PD).
|
31504668 |
2020 |
Parkinson Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Particularly, it has been reported that mitophagy could hinder the development of PD by activating the PINK1/Parkin pathway and acting as a defense mechanism against the induction of diabetes.
|
31730816 |
2020 |
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Cognitive impairment was reported in all monogenic PD forms with variable rates (58.8% PINK1, 53.9% SNCA, 50% DJ1, 29.2% VPS35, 15.7% LRRK2 and 7.4% Parkin).
|
31686421 |
2020 |
Parkinson Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Using PINK1<sup>B9</sup> mutant Dm, we aimed to explore the therapeutic action of ginseng total protein (GTP) on PD and provide in-depth scientific interpretation about the traditional efficacy of ginseng.
|
31562951 |
2020 |
Parkinson Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
These results are significant in expanding knowledge of early-onset deficits in the female Pink1-/- genetic rat model of PD.
|
31542395 |
2020 |
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In rare cases PD is caused by mutations in the genes for PINK1 (PTEN induced kinase 1) or PRKN (parkin RBR E3 ubiquitin protein ligase), which impair the selective autophagic elimination of damaged mitochondria (mitophagy).
|
30945962 |
2020 |
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Pink1 mutations are the second most common cause of autosomal recessive Parkinson's disease (PD).
|
31655049 |
2020 |
Parkinson Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
This study presented a new evidence for PINK1 and Parkin in participating in mitochondrial quality control and provided clues for further revealing the role of PINK1 and Parkin in the pathogenesis of PD.
|
31727366 |
2020 |
Parkinson Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
<b>Abbreviations:</b> CCCP: carbonyl cyanide 3-chlorophenylhydrazone; DUB: deubiquitinating enzymes; MPTP: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; OMM: outer mitochondrial membrane; PD: Parkinson disease; PINK1: PTEN induced kinase 1; PRKN/PARK2: parkin RBR E3 ubiquitin protein ligase; ROS: reactive oxygen species; TM: transmembrane; Ub: ubiquitin; UBA1: ubiquitin like modifier activating enzyme 1; UBE2L3/UbcH7: ubiquitin conjugating enzyme E2 L3; USP33: ubiquitin specific peptidase 33; WT: wild type.
|
31432739 |
2020 |
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The Parkinson's disease (PD)-related ubiquitin ligase Parkin and mitochondrial kinase PINK1 function together in the clearance of damaged mitochondria.
|
30375512 |
2019 |
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Mutations of PINK1 and PRKN/PARK2 contribute to the risk of Parkinson disease.
|
30252570 |
2019 |
Parkinson Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
The Parkinson disease-associated proteins PINK1 and PRKN coordinate the ubiquitination of mitochondrial outer membrane proteins to tag them either for degradation or for autophagic clearance of the mitochondrion.
|
30806158 |
2019 |
Parkinson Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
It has been leveraged to generate PD animal models, such as Parkin, DJ-1, and PINK1 triple knockout miniature pigs.
|
30879240 |
2019 |
Parkinson Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Several PD-related proteins are known to participate in the regulation of mitophagy, including PINK1 and Parkin.
|
31336937 |
2019 |
Parkinson Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Mitochondrial import efficiency was abnormally low in cells from patients with PINK1- and PARK2-linked Parkinson's disease and was restored by phosphomimetic ubiquitin in cells with residual Parkin activity.
|
31413265 |
2019 |
Parkinson Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Loss of either PINK1 or Parkin protein expression is associated with Parkinson's disease.
|
30885942 |
2019 |
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Mutations of PTEN-induced kinase 1 (PINK1) cause recessive familial Parkinson's disease.
|
31362890 |
2019 |
Parkinson Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
We hypothesized that chronic psychological distress induces PD-like symptoms and promotes neurodegeneration in wild-type (WT) rats and exacerbates PD pathology in PINK1 knockout (KO) rats, a well-validated animal model of PD.
|
31836946 |
2019 |
Parkinson Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Mice that lack the PD-linked kinase PINK1 show impaired differentiation of adult-born neurons in the hippocampus.
|
30735759 |
2019 |
Parkinson Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
This suggests that pink1, atp13a2 and uchl1 expressions are regulated by inflammation, and this regulatory mechanism might be involved in the progress of PD.
|
31201839 |
2019 |
Parkinson Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Laryngeal muscle biology in the <i>Pink1-/-</i> rat model of Parkinson disease.
|
30844333 |
2019 |
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Mutations in <i>PRKN</i> and PTEN-Induced Putative Kinase 1 (<i>PINK1</i>) are well-established causes of autosomal recessive early-onset PD.
|
31344817 |
2019 |
Parkinson Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
The role of PINK1 in mitochondrial function and in PD pathogenesis remains to be elucidated thoroughly.
|
30504091 |
2019 |
Parkinson Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
These data support the idea that PINK1 is a repressor of the immune system, and provide a pathophysiological model in which intestinal infection acts as a triggering event in Parkinson's disease, which highlights the relevance of the gut-brain axis in the disease<sup>10</sup>.
|
31316206 |
2019 |
Parkinson Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
LRRK2 impairs PINK1/Parkin-dependent mitophagy via its kinase activity: pathologic insights into Parkinson's disease.
|
30629163 |
2019 |