PINK1, PTEN induced kinase 1, 65018

N. diseases: 209; N. variants: 39
Disease: Forgetful ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0542476
Disease: Forgetful
Forgetful 		0.010 Biomarker phenotype BEFREE In both amyloid-β (Aβ) and tau Caenorhabditis elegans models of AD, mitophagy stimulation (through NAD<sup>+</sup> supplementation, urolithin A, and actinonin) reverses memory impairment through PINK-1 (PTEN-induced kinase-1)-, PDR-1 (Parkinson's disease-related-1; parkin)-, or DCT-1 (DAF-16/FOXO-controlled germline-tumor affecting-1)-dependent pathways. 30742114 2019