PINK1, PTEN induced kinase 1, 65018

N. diseases: 209; N. variants: 39
Disease: Carcinogenesis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.040 Biomarker phenotype BEFREE Our recent findings indicate that depletion of Pink1 and Prkn promotes pancreatic tumorigenesis in KRAS-driven engineered mouse models. 30252570 2019
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.040 GeneticVariation phenotype BEFREE PINK1 and Parkin have been proposed to act as tumor suppressors, as loss-of-function mutations are correlated with enhanced tumorigenesis. 31577952 2019
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.040 GeneticVariation phenotype BEFREE Using mouse models of spontaneous pancreatic cancer, we show that depletion of Pink1 and Park2 accelerates mutant Kras-driven pancreatic tumorigenesis. 30100261 2018
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.040 Biomarker phenotype BEFREE Our data indicate that TH/PINK1/Parkin pathway has a critical role in protecting hepatocytes from HBx-induced carcinogenesis. 28504722 2017