Essential Tremor
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Recently, a genome-wide association study of a Caucasian population identified variant rs3794087 in intron 4 of the SLC1A2 gene, which may increase the risk of essential tremor (ET).
|
29275184 |
2018 |
Essential Tremor
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Cerebellar cortical EAAT2 levels were 20% and 40% lower in ET cases vs. controls in the discovery and the replicate cohorts (respective p values = 0.045 and < 0.001).
|
27624392 |
2016 |
Essential Tremor
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
SLC1A2 rs3794087 are associated with susceptibility to Parkinson's disease, but not essential tremor, amyotrophic lateral sclerosis or multiple system atrophy in a Chinese population.
|
27206883 |
2016 |
Essential Tremor
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Replication of two lead single nucleotide polymorphisms of previous small genome-wide association studies (rs3794087 in SLC1A2, rs9652490 in LINGO1) did not confirm the association with essential tremor.
|
27797806 |
2016 |
Essential Tremor
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A family study of DRD3 rs6280, SLC1A2 rs3794087 and MAPT rs1052553 variants in essential tremor.
|
27456607 |
2016 |
Essential Tremor
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The meta-analysis included five association studies for the SLC1A2 rs3794087 SNP (1925 ET patients, 4914 controls) and the risk for ET.
|
26313486 |
2015 |
Essential Tremor
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Two genome-wide association studies demonstrated association between variants in the LINGO1 gene (leucine-rich repeat and Ig domain containing 1) and the SLC1A2 gene (solute carrier family 1 member 2) and ET, respectively.
|
24532269 |
2014 |
Essential Tremor
|
0.200 |
Biomarker
|
disease |
BEFREE |
Further studies in ethnically distinct populations of patients with ET are necessary to understand whether genetic variability in SLC1A2 affects disease risk for ET.
|
24139280 |
2014 |
Essential Tremor
|
0.200 |
Biomarker
|
disease |
BEFREE |
Our results were similar to those of the second GWAS of ET in Europeans, and this confirms that SLC1A2 may be a good functional candidate gene for ET.
|
23951268 |
2013 |
Essential Tremor
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our study suggests that SLC1A2 rs3794087 is not associated with the risk for developing familial ET in the Spanish population, thus subtracting relevance to SLC1A2 rs3794087 as a risk biomarker for ET.
|
23949322 |
2013 |
Essential Tremor
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
(5) We conducted a case-control study to examine the SLC1A2 gene variant in an Asian cohort of ET.
|
23596072 |
2013 |
Essential Tremor
|
0.200 |
Biomarker
|
disease |
BEFREE |
We identified SLC1A2 encoding the major glial high-affinity glutamate reuptake transporter in the brain as a potential ET susceptibility gene.
|
22764253 |
2012 |
Essential Tremor
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Polymorphisms in the glial glutamate transporter SLC1A2 are associated with essential tremor.
|
22764253 |
2012 |
Essential Tremor
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Polymorphisms in the glial glutamate transporter SLC1A2 are associated with essential tremor.
|
22764253 |
2012 |