Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Xenograft tumor models were developed to investigate the functions of p65 and miR-23a in vivo.
|
31769216 |
2020 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Protein levels of TRIM59 and p65 in xenograft tumor were determined by western blot.
|
30932261 |
2019 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In vivo, combination treatment of the xenograft model with EVO and GEM led to a significant reduction in tumor volume growth and inhibited the activation of NF-κB p65 with no obvious adverse reactions.
|
30643424 |
2019 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Tumor growth curve, body weight, and the expression of p65 nuclear factor (NF)-κB and the secretion of interferon (IFN)-γ were investigated.
|
31221816 |
2019 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Moreover, SP significantly enhanced the expression of NF-κB p65 and the tumor-associated cytokines, while, Akt inhibitor could reverse these effects.
|
30903649 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In the animal experiments, IATL reduced the size and weight of glioma tumors in xenograft mice and inhibited the expression of COX-2 and phosphorylated NF-κB p65 in the transplanted tumors.
|
30740911 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The previous studies have revealed that RA had therapeutic effects on hepatocellular carcinoma (HCC) in the <i>H22</i>-xenograft models by inhibiting the inflammatory cytokines and NF-κB p65 pathway in the tumor microenvironment.
|
31680772 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
NKILA serves as a tumor suppressor in laryngeal cancer by suppressing laryngeal cancer cell viability and migration, whereas promoting cell apoptosis; NKILA knockdown reverses the cytotoxicity of X-ray radiation on laryngeal cancer cells through combining with NF-κB: IκB complex to inhibit IκB phosphorylation, inhibit p65 nuclear translocation, and finally inhibit NF-κB activation.
|
29573243 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Conclusion The levels of NF-κB p50 and NF-κB p65 in samples of thyroid carcinoma were positively associated with tumour diameter and the presence of lymph node metastasis.
|
30014762 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Histological analysis indicated that apoptotic bodies were increased and NF-κB nuclear translocation factors, including Ikkβ, p65 and IkBα, were decreased in tumors treated by Chanti-TRIM.
|
29467844 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, we also examine underlying mechanism by which lncRNA 00607 regulates NF-κB p65 and how LIN00607 exerts its tumor suppressor role in HCC.
|
30169594 |
2018 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
While, HPV-ve CSCs show exclusively p50 homodimeriztion, poor differentiation and worst prognosis, HPV infection induced participation of p65 along with deregulated expression of specific miRNAs led to well differentiation of tumors and better prognosis.
|
30372446 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, in vitro tumor cell-macrophage co-culture and recombinant protein stimulation revealed that Angptl2 fostered the M2 polarization of TAMs through the p65 nuclear factor-kappa B (NF-ĸB) pathway.
|
29218246 |
2017 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Proinflammatory cytokines (IFNγ, MCP1, MIP1α, and TNFα) and myeloid differentiation factor (Endoglin) were increased in myeloid cells from p65 KO tumor, which demonstrated an influence on CD8+T cell proliferation.
|
29062041 |
2017 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The results of immunohistochemistry for the cervical cancer microarray showed that a lower level of STC1, phospho-PI3K and P65 protein expression in tumor tissues than that in normal tissues, and a higher level of phospho-P65 protein expression in tumor tissues, which is consistent with the results of the Western blotting.
|
28545028 |
2017 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Taken together, we revealed that NF-κB p65 potentiated tumor growth via suppressing a novel target LPTS.
|
29017500 |
2017 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Dietary supplementation with δ-T and γ-T significantly reduced colon tumor formation and suppressed markers of oxidative and nitrosative stress (i.e., 8-oxo-dG and nitrotyrosine) as well as pro-inflammatory mediators (i.e., NF-κB p65 and p-STAT3) in tumors and adjacent tissues.
|
27175800 |
2017 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The aim of the present study was to examine the relationship between tumour NF-κB activation, tumour microenvironment including local inflammatory response (LIR) and cancer-specific survival in patients with operable ductal breast cancer.Immunohistochemistry (tissue microarray of 376 patients) and western blotting (MCF7 and MDA-MB-231 breast cancer cells) was performed to assess expression of key members of the canonical NF-κB pathway (inhibitory kappa B kinase (IKKβ) and phosphorylated p65 Ser-536 (p-p65)).
|
28423692 |
2017 |
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
In vivo studies confirmed that platycodin D retarded the growth of subcutaneous SCC-4 xenograft tumors and reduced phosphorylation of NF-κB p65.
|
28548219 |
2017 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In vivo, wogonin could suppress tumor growth, associated with the downregulation of ki67, p65 and upregulation of PU.1.
|
28222771 |
2017 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Linarin significantly triggered apoptosis as well as the tumor growth in animals, accompanied with p53 increase and p65 decrease.
|
28858735 |
2017 |
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
In line with the above, our results confirmed the synergistic effects of FZKA and gefitinib combination on tumor growth, the phosphorylation of Akt, and protein expression of p65 and MUC1 in vivo.
|
27989877 |
2016 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Finally, solamargine increased phosphorylation of AMPKα, while inhibiting MUC1, p65 and tumor growth were observed in vivo.
|
27830724 |
2016 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We found that the expression levels of TNFSF13, ki-67, and NF-κB p65 in LSCC tumor tissues were higher than those in vocal polyp and para-carcinoma tissues.
|
26395262 |
2016 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Patients with tumor tissues that UBD-positive expression alone or in combination with p65 nuclei translocation recurred early had a significantly shorter survival time (P < 0.001), especially in stage IIB-IIC patients.
|
25238407 |
2015 |