BMP4, bone morphogenetic protein 4, 652

N. diseases: 423; N. variants: 21
Disease: Primary malignant neoplasm of lung ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.070 AlteredExpression disease BEFREE BMP4 level was associated with lobulation sign, spinous process sign, tumor diameter and mediastinal lymph node metastasis in CT findings (p<0.05), rather than spiculation sign, ground glass sign, calcification lesion and CT enhancement value of lung cancer (p>0.05). 31298330 2019
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.070 Biomarker disease BEFREE A xenograft tumour mouse model was established to address the roles of microRNA-876-5p and BMP-4 in lung cancer EMT <i>in vivo</i>. 29229885 2017
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.070 Biomarker disease BEFREE Regarding that many developmental pathways in embryogenesis are dysregulated in cancer, we aim to unravel the role of FSTL1-BMP4-Smad pathway in lung cancer. 28852126 2017
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.070 AlteredExpression disease BEFREE BMP4 expression levels in murine lung cancer cells were measured by quantitative reverse transcription-PCR (qRT-PCR) and Western blotting. 26395571 2015
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.070 AlteredExpression disease BEFREE Meanwhile, the ERK1/2 (extracellular-signal-regulated kinase 1/2) pathway, which is required for senescence, was not activated by BMP4 in the lung cancer cell line NCI-H460. 21050181 2011
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.070 Biomarker disease BEFREE BMP4-Smad signaling pathway mediates adriamycin-induced premature senescence in lung cancer cells. 19269967 2009
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.070 AlteredExpression disease BEFREE Our study has shown that the expressions of the VEGF, BMP-2 and BMP-4 mRNAs were significantly higher (7.1-fold, 25.6-fold and 2.3-fold, respectively) in lung cancer samples than in adjacent normal lung tissues (real-time RT-PCR). 19324447 2009