|
Thyroid Dyshormonogenesis 1
|
0.700 |
GermlineCausalMutation
|
disease |
ORPHANET |
Genetic causes of congenital hypothyroidism due to dyshormonogenesis.
|
21543982 |
2011 |
|
Thyroid Dyshormonogenesis 1
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Congenital hypothyroidism caused by a mutation in the Na+/I- symporter.
|
9171822 |
1997 |
|
Thyroid Dyshormonogenesis 1
|
0.700 |
GeneticVariation
|
disease |
UNIPROT |
Congenital hypothyroidism caused by a mutation in the Na+/I- symporter.
|
9171822 |
1997 |
|
Thyroid Dyshormonogenesis 1
|
0.700 |
GermlineCausalMutation
|
disease |
ORPHANET |
Congenital hypothyroidism.
|
20537182 |
2010 |
|
Thyroid Dyshormonogenesis 1
|
0.700 |
GeneticVariation
|
disease |
UNIPROT |
Novel, missense and loss-of-function mutations in the sodium/iodide symporter gene causing iodide transport defect in three Japanese patients.
|
9745458 |
1998 |
|
Thyroid Dyshormonogenesis 1
|
0.700 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Thyroid Dyshormonogenesis 1
|
0.700 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Thyroid Dyshormonogenesis 1
|
0.700 |
GeneticVariation
|
disease |
UNIPROT |
Congenital hypothyroidism due to mutations in the sodium/iodide symporter. Identification of a nonsense mutation producing a downstream cryptic 3' splice site.
|
9486973 |
1998 |
|
Thyroid Dyshormonogenesis 1
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Extending the clinical heterogeneity of iodide transport defect (ITD): a novel mutation R124H of the sodium/iodide symporter gene and review of genotype-phenotype correlations in ITD.
|
16418213 |
2006 |
|
Thyroid Dyshormonogenesis 1
|
0.700 |
GeneticVariation
|
disease |
UNIPROT |
A novel mutation in the sodium/iodide symporter gene in the largest family with iodide transport defect.
|
10487695 |
1999 |
|
Thyroid Dyshormonogenesis 1
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
MicroRNAs let7 expression in thyroid cancer: correlation with their deputed targets HMGA2 and SLC5A5.
|
26960757 |
2016 |
|
Malignant neoplasm of breast
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The goal of this study was to evaluate if the recently introduced PET radiotracer [<sup>18</sup>F]tetrafluoroborate ([<sup>18</sup>F]BF<sub>4</sub><sup>-</sup>) is useful for sensitive and specific metastasis detection in an orthotopic xenograft breast cancer model expressing the human sodium iodide symporter (NIS) as a reporter.
|
28424464 |
2017 |
|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
These data demonstrate selective induction of functional NIS in breast cancer by tRA.
|
14729653 |
2004 |
|
Malignant neoplasm of breast
|
0.400 |
Therapeutic
|
disease |
CTD_human |
The rat sodium iodide symporter gene permits more effective radioisotope concentration than the human sodium iodide symporter gene in human and rodent cancer cells.
|
12489024 |
2003 |
|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results indicate that the mammary gland sodium/iodide symporter may be an essential breast cancer marker and that radioiodide should be studied as a possible option in the diagnosis and treatment of breast cancer.
|
10932223 |
2000 |
|
Malignant neoplasm of breast
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Retinoic acid induces sodium/iodide symporter gene expression and radioiodide uptake in the MCF-7 breast cancer cell line.
|
10890895 |
2000 |
|
Malignant neoplasm of breast
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In vivo radioiodide imaging and treatment of breast cancer xenografts after MUC1-driven expression of the sodium iodide symporter.
|
15746050 |
2005 |
|
Malignant neoplasm of breast
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In this study, using breast cancer cell lines, we established that tRA-responsive NIS expression is confined to estrogen receptor-alpha (ERalpha) positive cells and we investigated the role of ERalpha in the regulation of NIS expression.
|
16730657 |
2006 |
|
Malignant neoplasm of breast
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Using quantitative real-time RT-PCR, we found that all 22 fresh human breast cancer samples had very low NIS expression similar to levels in untreated MCF-7 breast cancer cells.
|
12846418 |
2003 |
|
Malignant neoplasm of breast
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Characterization and application of NIS as a novel therapeutic gene and the presence of high native NIS expression in the majority of breast cancers further suggest a promising role of NIS in diagnosis and therapy of cancer outside the thyroid gland.
|
12390328 |
2002 |
|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, this study shows the important role of mannosidase in N-glycosylation processing in order to correctly traffic NIS to the plasma membrane in breast cancer cells.This article has an associated First Person interview with the first author of the paper.
|
31455607 |
2019 |
|
Malignant neoplasm of breast
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The sodium/iodide symporter (NIS) mediates iodide uptake in lactating breast tissue and is expressed in some breast cancers.
|
15817668 |
2005 |
|
Malignant neoplasm of breast
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
One is based on the reinduction of endogenous NIS expression in thyroid and breast cancer by targeting the main mechanisms involving tumoral transformation and dedifferentiation.
|
16990649 |
2006 |
|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
Since the sodium/iodide symporter (NIS) stimulates the iodine uptake in normal lactating breast, our study aimed to study the effect of NIS-mediated radioiodide therapy on ER-negative breast cancers.
|
25955347 |
2015 |
|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
Human breast cancer MDA-MB-231 cells transfected with the hNIS gene were injected subcutaneously into the right flanks of BALB/c nude mice.
|
22003972 |
2011 |