|
Abdomen distended
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Adenocarcinoma
|
0.010 |
Biomarker
|
group |
BEFREE |
In addition to characterizing the hormonal regulation of the mammary gland sodium/iodide symporter, we demonstrate by scintigraphy that mammary adenocarcinomas in transgenic mice bearing Ras or Neu oncogenes actively accumulate iodide by this symporter in vivo.
|
10932223 |
2000 |
|
Adenocarcinoma of lung (disorder)
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We investigated whether increased accumulation of iodine can be induced by sodium butyrate through a newly developed baculoviral transfer of the human NIS (hNIS) gene in A549 human lung adenocarcinoma.
|
20683361 |
2010 |
|
Adenocarcinoma of prostate
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Although transduction of the hNIS gene induces iodide transport in rat prostate adenocarcinoma a rapid efflux occurs, which leads to a low absorbed dose in genetically modified tumors.
|
12704416 |
2003 |
|
Adenocarcinoma of prostate
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We reported recently the induction of androgen-dependent iodide uptake activity in the human prostatic adenocarcinoma cell line LNCaP using a prostate-specific antigen (PSA) promoter-directed expression of the sodium iodide symporter (NIS) gene.
|
12865321 |
2003 |
|
Adenoma
|
0.040 |
AlteredExpression
|
group |
BEFREE |
In all functioning thyroid nodules (toxic adenomas), a high expression of hNIS protein was detected with respect to normal surrounding tissue.
|
11788674 |
2002 |
|
Adenoma
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Increased NIS expression has been found in autonomous adenoma and Graves' disease, decreased levels of NIS protein and/or mRNA were observed in Hashimoto's disease, cold nodules, most thyroid cancers and cell lines derived therefrom.
|
9865544 |
1998 |
|
Adenoma
|
0.040 |
AlteredExpression
|
group |
BEFREE |
In this study we evaluated the expression of CREB and NIS gene in thyroid non-functioning adenomas (n=18) and carcinomas (n=20), as well as in the corresponding normal tissue.
|
12720543 |
2003 |
|
Adenoma
|
0.040 |
Biomarker
|
group |
BEFREE |
By immunohistochemistry, staining of hNIS protein was stronger in Graves' and toxic adenomas and reduced in thyroid carcinomas.
|
10576759 |
1999 |
|
Adenomatous Polyposis Coli
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Tumors of transgenic mouse models for colorectal cancer harboring mutations in the oncogenes KRAS, beta-catenin or the tumor-suppressor gene adenomatous-polyposis coli (APC) were screened for NIS expression by RT-PCR.
|
19569179 |
2009 |
|
Adult Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
A mammalian NIS expression vector was constructed and used to generate six stable NIS-expressing cancer cell lines (three derived from thyroid carcinoma, two from colon carcinoma, one from glioblastoma).
|
12111124 |
2002 |
|
Adult Hepatocellular Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
The dual-targeting approach was used to deliver the theranostic sodium iodide symporter (NIS) gene to hepatocellular cancer.
|
30683895 |
2019 |
|
Adult Hepatocellular Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Hypoxia-targeted 131I therapy of hepatocellular cancer after systemic mesenchymal stem cell-mediated sodium iodide symporter gene delivery.
|
27458162 |
2016 |
|
Adult Hepatocellular Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Sodium iodide symporter (NIS)-mediated radiovirotherapy of hepatocellular cancer using a conditionally replicating adenovirus.
|
23038026 |
2013 |
|
Adult Hepatocellular Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Image-guided, tumor stroma-targeted 131I therapy of hepatocellular cancer after systemic mesenchymal stem cell-mediated NIS gene delivery.
|
21587211 |
2011 |
|
Adult Liver Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
And we measured the correlation of fluorescent intensities and 125I uptake amount in HepG2 cells after co-vector administration with Bac-NIS and Bac-GFP at different MOIs, and found a high correlation coefficient (r(2) = 0.8447), which provides a good basis for successfully evaluating the feasibility of baculovirus-mediated NIS reporter gene monitoring target gene expression in liver cancer therapy.
|
23919394 |
2014 |
|
Adult Liver Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
Epidermal growth factor receptor-targeted (131)I-therapy of liver cancer following systemic delivery of the sodium iodide symporter gene.
|
21245850 |
2011 |
|
Adult Liver Carcinoma
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
We have investigated sodium iodide symporter expression and functionality in human liver cancer, and in a diethylnitrosamine induced Wistar rat model of primary liver cancer at different stages of carcinogenesis.
|
17408651 |
2007 |
|
Adult Liver Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
We coated replication-deficient (Ad5-CMV/NIS) (CMV is cytomegalovirus) and replication-selective (Ad5-E1/AFP-E3/NIS) adenovirus serotype 5 carrying the hNIS gene with poly(amidoamine) dendrimers generation 5 (PAMAM-G5) in order to investigate transduction efficacy and altered tropism of these coated virus particles by (123)I scintigraphy and to evaluate their therapeutic potential for systemic radiovirotherapy in a liver cancer xenograft mouse model.
|
23843567 |
2013 |
|
Adult Liver Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
Sodium iodide symporter (NIS)-mediated radionuclide ((131)I, (188)Re) therapy of liver cancer after transcriptionally targeted intratumoral in vivo NIS gene delivery.
|
21488714 |
2011 |
|
Adult Liver Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
Image-guided tumor-selective radioiodine therapy of liver cancer after systemic nonviral delivery of the sodium iodide symporter gene.
|
21851208 |
2011 |
|
Adult Medulloblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The effects of MV-NIS were also evaluated in mouse xenograft models of localized and disseminated medulloblastoma.
|
23134812 |
2012 |
|
Amyloidosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Development of measures of polyneuropathy impairment in hATTR amyloidosis: From NIS to mNIS + 7.
|
31445300 |
2019 |
|
Anaplasia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
However, in thyroid carcinoma, down-regulated or mis-targeted NIS expression is commonly found and usually correlates with tumor dedifferentiation and loss of radioiodine uptake capacity.
|
16253762 |
2005 |
|
Anaplasia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
One is based on the reinduction of endogenous NIS expression in thyroid and breast cancer by targeting the main mechanisms involving tumoral transformation and dedifferentiation.
|
16990649 |
2006 |