|
Thyroid Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Thyroid iodide uptake, mediated by the sodium-iodide symporter (NIS), is essential for thyroid hormone synthesis and also for treatment of thyroid diseases, such as thyroid cancer, through radioiodine therapy.
|
29160164 |
2018 |
|
Thyroid Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
[18F]-tetrafluoroborate accumulates in cells expressing hNIS or rat sodium/iodide symporter and is a potential PET imaging agent in thyroid disease and hNIS reporter gene imaging.
|
21085047 |
2011 |
|
Thyroid Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Synthesis and biological evaluation of [(18)F]tetrafluoroborate: a PET imaging agent for thyroid disease and reporter gene imaging of the sodium/iodide symporter.
|
20577737 |
2010 |
|
Thyroid Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Cloning and molecular characterization of the NIS have allowed the investigation of its key role in thyroid physiology as well as its potential pathophysiological and therapeutic implications in benign and malignant thyroid diseases.
|
16990649 |
2006 |
|
Thyroid Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Radioiodide is routinely and effectively used for the treatment of benign and malignant thyroid disease as a result of native thyroidal expression of NIS, which mediates iodide uptake.
|
16121204 |
2006 |
|
Thyroid Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The sodium-iodide-symporter (NIS) plays a key role in iodination, the first step in the biosynthesis of the thyroid hormones, and is thought to be critically involved in several thyroid disorders associated with altered iodine up-take.
|
12518250 |
2002 |
|
Thyroid Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
In addition to its key function in thyroid physiology, NIS-mediated iodide accumulation allows diagnostic thyroid scintigraphy as well as effective therapeutic application of radioiodine in benign and malignant thyroid disease.
|
12390328 |
2002 |
|
Thyroid Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The NIS is expressed in thyroid tissue of patients with autoimmune thyroid diseases, and its expression is increased in Graves' disease.
|
11573136 |
2001 |
|
Thyroid Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Thus, although the controversy has not been definitively resolved, hNIS does not appear to be a major functionally relevant antigen in autoimmune thyroid diseases.
|
11573137 |
2001 |
|
Thyroid Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The recent cloning of the gene encoding the sodium/iodide symporter (NIS) has enabled better characterization of the molecular mechanisms underlying iodide transport, thus opening the way to clarifying its role in thyroid diseases.
|
10576759 |
1999 |
|
Thyroid Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
NIS mutations are found in congenital hypothyroidism, and potential defects in the NIS gene, its expression, or function of the NIS protein are currently under investigation in various thyroid diseases.
|
9865544 |
1998 |