|
Thyroid Neoplasm
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In an in vivo orthotopic model, the enhancement of miR-875-5p led to the reduction of NIS expression and radioiodine uptake in the thyroid tumors.
|
31612419 |
2020 |
|
Thyroid Neoplasm
|
0.400 |
Biomarker
|
disease |
BEFREE |
NIS has been exploited for over 75 years in ablative radioiodine (RAI) treatment of thyroid cancer, where its ability to transport radioisotopes depends on its localization to the plasma membrane.
|
31672844 |
2020 |
|
Thyroid Neoplasm
|
0.400 |
Biomarker
|
disease |
BEFREE |
Enhancement of <sup>211</sup>At Uptake via the Sodium Iodide Symporter by the Addition of Ascorbic Acid in Targeted α-Therapy of Thyroid Cancer.
|
30796173 |
2019 |
|
Thyroid Neoplasm
|
0.400 |
Biomarker
|
disease |
BEFREE |
The Sodium Iodide Symporter (NIS), responsible for active transport of iodide into thyroid cells, allows the use of radioactive iodine (RAI) as the systemic treatment of choice for TC metastatic disease.
|
31590142 |
2019 |
|
Thyroid Neoplasm
|
0.400 |
Biomarker
|
disease |
BEFREE |
Sodium/iodide symporter (NIS)-mediated iodide uptake plays an important physiological role in regulating thyroid gland function, as well as in diagnosing and treating Graves' disease and thyroid cancer.
|
31331356 |
2019 |
|
Thyroid Neoplasm
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
NIS expression in thyroid tumors, relation with prognosis clinicopathological and molecular features.
|
29298843 |
2018 |
|
Thyroid Neoplasm
|
0.400 |
Biomarker
|
disease |
BEFREE |
These studies evaluating the etiological roles of these factors in linking breast and thyroid cancer might also improve our understanding and identify new therapeutic approaches, such as sodium/iodide symporter-mediated radioiodine therapy and thyroid-stimulating hormone receptor antagonists, for breast cancer.
|
29976206 |
2018 |
|
Thyroid Neoplasm
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Non-invasive NIS imaging with radioactive iodides and iodide analogs has gained much interest in recent years for evaluation of thyroid cancer and NIS reporter expression.
|
30083270 |
2018 |
|
Thyroid Neoplasm
|
0.400 |
Biomarker
|
disease |
BEFREE |
Noninvasive imaging of iodide uptake via the sodium/iodide symporter (NIS) has received great interest for evaluation of thyroid cancer and reporter imaging of NIS-expressing viral therapies.
|
29198608 |
2018 |
|
Thyroid Neoplasm
|
0.400 |
Biomarker
|
disease |
BEFREE |
Radioactive iodide has been the mainstay adjuvant treatment for thyroid cancer for the last seven decades by virtue of its active transport by NIS.
|
29437784 |
2018 |
|
Thyroid Neoplasm
|
0.400 |
Biomarker
|
disease |
BEFREE |
Epigenetic Modifications in Thyroid Cancer Cells Restore NIS and Radio-Iodine Uptake and Promote Cell Death.
|
29561759 |
2018 |
|
Thyroid Neoplasm
|
0.400 |
Biomarker
|
disease |
BEFREE |
In summary, our results elucidate a pump-independent, protumorigenic role for NIS in thyroid cancer via its cross-talk with PTEN signaling.<b>Significance:</b> A novel pump-independent protumorigenic role of nonmembranous NIS challenges the presumption that radioiodine treatment of thyroid cancer is ineffective when transmembrane NIS is not expressed.<i></i>.
|
30217930 |
2018 |
|
Thyroid Neoplasm
|
0.400 |
Biomarker
|
disease |
BEFREE |
Selumetinib Activity in Thyroid Cancer Cells: Modulation of Sodium Iodide Symporter and Associated miRNAs.
|
30018229 |
2018 |
|
Thyroid Neoplasm
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Aberrant expression of the sodium-iodide symporter (NIS) and the resistance to post-operative radioactive iodide treatment is a crucial cause of higher mortality of some thyroid cancer patients.
|
29495389 |
2018 |
|
Thyroid Neoplasm
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thyroid iodide uptake, mediated by the sodium-iodide symporter (NIS), is essential for thyroid hormone synthesis and also for treatment of thyroid diseases, such as thyroid cancer, through radioiodine therapy.
|
29160164 |
2018 |
|
Thyroid Neoplasm
|
0.400 |
Biomarker
|
disease |
BEFREE |
The present study explored the combined cytotoxic effects of adenovirus-mediated CD and NIS under the control of the progression elevated gene-3 (<i>PEG-3</i>) promoter (Ad-PEG-3-CD-NIS) with Na<sup>131</sup>I/5-FC against the human thyroid cancer TT cell line <i>in vitro</i>.
|
29344184 |
2017 |
|
Thyroid Neoplasm
|
0.400 |
Biomarker
|
disease |
BEFREE |
Cell penetrating peptide of sodium-iodide symporter effect on the I-131 radiotherapy on thyroid cancer.
|
28450931 |
2017 |
|
Thyroid Neoplasm
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Remarkably, analysis of human and murine BRAF<sup>V600E</sup>-mutated thyroid tumors highlights that the level of NOX4 expression is inversely correlated to thyroid differentiation suggesting that other genes involved in thyroid differentiation in addition to NIS might be silenced by a mechanism controlled by NOX4-derived ROS.
|
27401113 |
2017 |
|
Thyroid Neoplasm
|
0.400 |
Biomarker
|
disease |
BEFREE |
These data support further translational studies with <sup>18</sup>F-TFB as NIS gene reporter and imaging biomarker for thyroid cancer and other disease processes that import iodide.
|
29080017 |
2017 |
|
Thyroid Neoplasm
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thyroid concentrates radioactive iodine by sodium-iodide symporter; this is used for treating hyperthyroidism and thyroid cancer.
|
28283939 |
2017 |
|
Thyroid Neoplasm
|
0.400 |
Biomarker
|
disease |
BEFREE |
Radioiodine whole body scan (WBS), related to sodium iodide symporter (NIS) function, is widely used to detect recurrence/metastasis in postoperative patients with thyroid cancer.
|
28386277 |
2017 |
|
Thyroid Neoplasm
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Abundant sodium/iodide symporter protein expression in thyroid cancer cells under these conditions was confirmed by immunofluorescent microscopy.
|
26751190 |
2016 |
|
Thyroid Neoplasm
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
MicroRNAs let7 expression in thyroid cancer: correlation with their deputed targets HMGA2 and SLC5A5.
|
26960757 |
2016 |
|
Thyroid Neoplasm
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, our study has uncovered the existence of a miR-146b-3p/PAX8/NIS regulatory circuit that may be exploited therapeutically to modulate thyroid cell differentiation and iodide uptake for improved treatment of advanced thyroid cancer.
|
26282166 |
2015 |
|
Thyroid Neoplasm
|
0.400 |
Biomarker
|
disease |
BEFREE |
Gene expression was analyzed using fluidic cards containing probes and primers specific for the THRβ gene, as well as for genes of thyroperoxidase (TPO), sodium/iodide symporter (NIS), thyroglobulin (Tg) and thyroid stimulating hormone receptor (TSH-R) and for some miRNAs involved in thyroid neoplasia and targeting THRβ.
|
26003825 |
2015 |