SLC6A2, solute carrier family 6 member 2, 6530

N. diseases: 238; N. variants: 24
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.010 Biomarker disease BEFREE The positive association between MetS and GEP-NET characteristics further highlights the potential link between the two conditions. 31533348 2019
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.050 Biomarker phenotype BEFREE However, there is no information about a possible role of NLR, PLR and PWR as predictor of presence of metastasis or multifocal disease in patients undergoing surgery with curative intent for midgut NET. 31520198 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE Although there is no category corresponding to NET G3 in the current classification of lung tumors, we consider that our tumors may correspond to NET G3 and identification of this subset is relevant for therapeutic management. 31511024 2019
CUI: C0206695
Disease: Carcinoma, Neuroendocrine
Carcinoma, Neuroendocrine
0.100 GeneticVariation disease BEFREE Herein, we report two cases of lung neuroendocrine carcinoma with carcinoid morphology that correspond to NET G3. 31511024 2019
CUI: C0206754
Disease: Neuroendocrine Tumors
Neuroendocrine Tumors
0.100 GeneticVariation group BEFREE The category of grade 3 neuroendocrine tumor (NET G3) was newly introduced in the 2017 World Health Organization (WHO 2017) classification of neuroendocrine neoplasms of the pancreas. 31511024 2019
CUI: C0007095
Disease: Carcinoid Tumor
Carcinoid Tumor
0.050 GeneticVariation phenotype BEFREE Herein, we report two cases of lung neuroendocrine carcinoma with carcinoid morphology that correspond to NET G3. 31511024 2019
CUI: C0334299
Disease: Carcinoid tumor no ICD-O subtype
Carcinoid tumor no ICD-O subtype
0.030 GeneticVariation phenotype BEFREE Herein, we report two cases of lung neuroendocrine carcinoma with carcinoid morphology that correspond to NET G3. 31511024 2019
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.010 Biomarker group BEFREE There is no category corresponding to NET G3 in the current WHO 2015 classification of lung tumors. 31511024 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 GeneticVariation group BEFREE Stratified by the tumour grade (WHO 2010 classification), we observed 64.0% of NET G1, 24.7% of NET G2, and 11.3% of NEC. 31467527 2019
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease BEFREE The serotonin transporter belongs to the family of sodium-chloride coupled neurotransmitter transporter and is related to depression in humans. 31442583 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker disease BEFREE The serotonin transporter belongs to the family of sodium-chloride coupled neurotransmitter transporter and is related to depression in humans. 31442583 2019
CUI: C0344315
Disease: Depressed mood
Depressed mood
0.100 Biomarker phenotype BEFREE The serotonin transporter belongs to the family of sodium-chloride coupled neurotransmitter transporter and is related to depression in humans. 31442583 2019
CUI: C0206695
Disease: Carcinoma, Neuroendocrine
Carcinoma, Neuroendocrine
0.100 Biomarker disease BEFREE NET G3 are considered a molecularly, radiologically, and prognostically distinct entity compared to NEC and NET G1/G2. 31428952 2019
CUI: C0011884
Disease: Diabetic Retinopathy
Diabetic Retinopathy
0.010 AlteredExpression disease BEFREE Since the NET could provide negative-charged surface for factor XII activation and the activated factor XII (XIIa) can initiate kallikrein-kinin system, this study investigated whether patients with DR show activation of NET, factor XII and kallikrein-kinin system. 31426112 2019
CUI: C0206695
Disease: Carcinoma, Neuroendocrine
Carcinoma, Neuroendocrine
0.100 Biomarker disease BEFREE No prognostic difference was detected between NET G3 and NEC patients after 5 year DFS. 31422400 2019
CUI: C4296893
Disease: Neuroendocrine tumor G2 (NET G2)
Neuroendocrine tumor G2 (NET G2)
0.090 Biomarker disease BEFREE NET G3 patients had a worse outcome than NET G1 (p<0.01) and NET G2 patients (p=0.02), respectively. 31422400 2019
Attention deficit hyperactivity disorder
0.100 Biomarker disease BEFREE A subgroup of 18 patients with ADHD and 18 healthy controls underwent positron emission tomography (PET) with the radioligand (S,S)-[<sup>18</sup>F]FMeNER-D<sub>2</sub> to quantify the NET in several brain areas in vivo. 31383926 2019
CUI: C0424295
Disease: Hyperactive behavior
Hyperactive behavior
0.060 AlteredExpression phenotype BEFREE Association of norepinephrine transporter methylation with in vivo NET expression and hyperactivity-impulsivity symptoms in ADHD measured with PET. 31383926 2019
CUI: C0278996
Disease: Malignant Head and Neck Neoplasm
Malignant Head and Neck Neoplasm
0.030 Biomarker disease BEFREE Advancing interdisciplinary research in head and neck cancer through a multicenter longitudinal prospective cohort study: the NETherlands QUality of life and BIomedical Cohort (NET-QUBIC) data warehouse and biobank. 31382921 2019
CUI: C3887461
Disease: Head and Neck Carcinoma
Head and Neck Carcinoma
0.030 Biomarker disease BEFREE Advancing interdisciplinary research in head and neck cancer through a multicenter longitudinal prospective cohort study: the NETherlands QUality of life and BIomedical Cohort (NET-QUBIC) data warehouse and biobank. 31382921 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.020 GeneticVariation disease BEFREE NET gene polymorphism might be associated with the risk of T2DM whereas; eNOS gene polymorphism do not confer any risk of T2DM in North Indian Ethnic group. 31377977 2019
CUI: C0206754
Disease: Neuroendocrine Tumors
Neuroendocrine Tumors
0.100 Biomarker group BEFREE Taking full advantage of positron emission tomography (PET) technology, fluorine-18-labelled radiotracers targeting norepinephrine transporter (NET) have potential applications in the diagnosis and assessment of cardiac sympathetic nerve conditions as well as the delineation of neuroendocrine tumours. 31332629 2019
CUI: C4551683
Disease: Adrenal Gland Pheochromocytoma
Adrenal Gland Pheochromocytoma
0.050 AlteredExpression disease BEFREE High-specific-activity, carrier-free I-131-MIBG has been developed over the past two decades as a novel therapy for patients with metastatic pheochromocytomas and paragangliomas that express the norepinephrine transporter. 31330766 2019
CUI: C0030421
Disease: Paraganglioma
Paraganglioma
0.030 AlteredExpression disease BEFREE High-specific-activity, carrier-free I-131-MIBG has been developed over the past two decades as a novel therapy for patients with metastatic pheochromocytomas and paragangliomas that express the norepinephrine transporter. 31330766 2019
CUI: C0031511
Disease: Pheochromocytoma
Pheochromocytoma
0.030 AlteredExpression disease BEFREE High-specific-activity, carrier-free I-131-MIBG has been developed over the past two decades as a novel therapy for patients with metastatic pheochromocytomas and paragangliomas that express the norepinephrine transporter. 31330766 2019