|
Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Then, we analyzed the expression of NET correlation with inflammatory cytokines to provide a new direction for detecting the association mechanism between depression and hypertension.
|
30957546 |
2020 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The serotonin transporter belongs to the family of sodium-chloride coupled neurotransmitter transporter and is related to depression in humans.
|
31442583 |
2019 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Melatonin treatment affects changes in adrenal gene expression of catecholamine biosynthesizing enzymes and norepinephrine transporter in the rat model of chronic-stress-induced depression.
|
30773040 |
2019 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The norepinephrine transporter occupancy at week 2 in hypothalamus but not in other regions predicted improvement in depression as reflected by reduction in MADRS scores from baseline to week 7.
|
29016993 |
2018 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
In addition, we found two genes, SLC6A4 and SLC6A2, to be the main therapeutic targets, and Serotonin-Norepinephrine Reuptake Inhibitors (SNRI) and Tricyclic Antidepressants (TCA) to be the most effective drugs for individuals with depression at risk for suicide.
|
29331709 |
2018 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The locus coeruleus (LC), which has high NET concentration, has been attributed to brain networks involved in depression.
|
30238915 |
2018 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Our study indicates that DNA methylation levels of nine CpG sites in NET gene promoter region are not associated with depression and hypertension.
|
28737436 |
2017 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Norepinephrine Transporter Gene Variants and Remission From Depression With Venlafaxine Treatment in Older Adults.
|
28068779 |
2017 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Our results suggest that a NET 182C and 5-HTTLPR polymorphism interaction is associated with susceptibility to treatment resistant depression and ECT treatment response in antidepressant resistant depression patients.
|
25650523 |
2015 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The NET and 5-HT1A polymorphisms appear to have similar effects on hippocampal volume in patients and controls while the 5-HTTLPR polymorphism differentially affects hippocampal volume in the presence of depression.
|
25990886 |
2015 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Although several studies have investigated possible associations between norepinephrine neurotransmitter transporter gene (SLC6A2) polymorphisms and depression, few studies have examined associations between SLC6A2 polymorphisms and suicide.
|
24655776 |
2014 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The results from our study do not suggest SLC6A2 as a susceptibility gene for depression in the Danish population.
|
23969988 |
2013 |
|
Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
The present findings demonstrate that corticosterone up-regulates the expression and function of NET in vitro, indicating the action of corticosterone on the noradrenergic phenotype may play an important role in the correlation between stress and the development of depression.
|
20070865 |
2010 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Seven polymorphisms in the promoter, intronic and exonic region of the NET gene, as well as serotonin-transporter-linked promoter region (5-HTTLPR) and 5-HTT rs25531 polymorphisms were analyzed with respect to antidepressant treatment response with particular attention to gender effects and subtypes of melancholic or anxious depression.
|
20588071 |
2010 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
In conclusion, our results favor the hypothesis that monoaminergic neurotransmission in general and the F528C NET and R219L 5-HT(1A) receptor variants in particular are involved in the pathogenesis of depression.
|
19105200 |
2009 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
It was shown that the NET-T182C, interacting with 5-HTTLPR, was associated with the susceptibility to depression.
|
19468717 |
2009 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Therefore, the neurotransmitter transporter genes, SLC6A3 (dopamine) and SLC6A4 (serotonin) are candidates for depression in PD.
|
18973248 |
2009 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
MPT analyses show significant associations of the norepinephrine transporter (NET, SLC6A2) -182 T/C (rs2242446) with recurrent depression [odds ratio, OR = 4.15 (1.91-9.02)], NET -3081 A/T (rs28386840) with increase in appetite [OR = 3.58 (1.53-8.39)] and the presynaptic choline transporter (CHT, SLC5A7) rs1013940" genes_norm="60482">Ile89Val (rs1013940) with HAM-D-17 total score {i.e. overall depression severity [OR = 2.74 (1.05-7.18)]}.
|
18081710 |
2008 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Since NE signaling contributes to diverse brain functions, we hypothesize that promoter variation within the human NET gene (solute carrier family 6, member 2; SLC6A2) may impact risk for NE-related disorders, including depression, attention deficit hyperactive disorder (ADHD), and autonomic dysfunction.
|
18591486 |
2008 |