|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The promoter region of the DAT1 gene may play a role in increasing susceptibility to schizophrenia, but does not affect the severity of psychotic symptoms in Han Chinese.
|
19879111 |
2010 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Because mutations of the dopamine transporter gene might underlie the cause of schizophrenia in a subset of families, we undertook a linkage analysis between schizophrenia in 9 families and a dopamine transporter gene polymorphism.
|
8406521 |
1993 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Considering the cumulative evidence from six case-control studies and results from additional family-based studies, it seems unlikely that the 40-base-pair VTNR polymorphism of the SLC6A3 gene influences risk for schizophrenia.
|
15567077 |
2005 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Dopamine transporter (DAT) genetic hypofunction in mice produces alterations consistent with ADHD but not schizophrenia or bipolar disorder.
|
28454982 |
2017 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We investigated the relationship between several functional polymorphisms in genes coding for dopamine metabolism and transport enzymes (MAO-A VNTR; MAO-A 941T>G; DAT VNTR; DAT -67A/T; CYP2D6*3; CYP2D6*4; CYP2D6*5; CYP2D6*6) and the frequency of schizophrenia.
|
20041956 |
2010 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We have therefore tried to find other single nucleotide polymorphisms (SNPs) in DAT1 gene and to use them as additional markers for the association study of schizophrenia.
|
15380858 |
2004 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
As impaired serotonergic and dopaminergic neurotransmission is implicated in the pathogenesis of depression and schizophrenia this study sought to investigate the putative association between several functional gene polymorphisms (SERT 5-HTTLPR, MAO-A VNTR, COMT Val158Met and DAT VNTR) and schizophrenia.
|
28416295 |
2017 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The authors assessed the linkage between this gene and schizophrenia spectrum disorders by using polymorphic dopamine transporter gene markers in 156 subjects from 16 multiplex pedigrees with schizophrenia as well as schizophreniform, schizoaffective, and schizotypal disorders and mood-incongruent psychotic depression.
|
7802105 |
1995 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We previously detected association between SZ and intronic SLC6A3 variants that replicated in two independent Caucasian samples, but had no obvious function.
|
20957647 |
2010 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In this study, we examined whether single nucleotide polymorphisms (SNPs) in SLC6A3, SLC6A4 were associated with schizophrenia in Han Chinese people (893 schizophrenia patients and 611 healthy controls).
|
25019689 |
2014 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
No significant differences in age at onset of psychotic symptoms, attention task performance or family loading for schizophrenia spectrum disorders were observed between groups with different DRD3 and DAT1 genotypes.
|
11104840 |
2001 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This study provides evidence that a genetic variant in the DRD2 gene and possible interaction between DRD3 and SLC6A3 genes are associated with schizophrenia.
|
19766158 |
2010 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
For the first time, these findings provide tentative evidence for the contribution of the DAT1 gene core promoter polymorphism to the etiopathophysiology of schizophrenia at least in the Iranian male population that we studied.
|
15274029 |
2004 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Two single nucleotide polymorphisms (SNPs) in the DAT1 gene (rs2975223 and rs2455391) were tested in 368 patients with schizophrenia and 420 healthy controls, of whom 293 patients underwent an assessment of psychotic symptoms through the positive and negative syndrome scale (PANSS).
|
22366190 |
2012 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Thus the aim of the present study was to investigate the possible association between a new single nucleotide polymorphism (rs6347) located in exon 9 of the protein transporter (SLC6A3) and schizophrenia.
|
21049181 |
2010 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This first hand evidence, regarding BDNF and DAT1 gene methylation and their expression profile with risk of schizophrenia, indicated a significant function for the BDNF gene in the development of schizophrenia.
|
23065263 |
2012 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
Polymorphisms in genes encoding the serotonin and dopamine pathways in two sisters with metachromatic leukodystrophy.
|
18831910 |
2008 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Taken together, these studies suggest that variation in the dopamine transporter gene (DAT1) is unlikely to be a factor in the etiology of schizophrenia.
|
8047618 |
1994 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
A network of dopaminergic gene variations implicated as risk factors for schizophrenia.
|
18045777 |
2008 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
Family-based study of markers at the 5'-flanking region of the human dopamine transporter gene reveals potential association with schizophrenic psychoses.
|
16783497 |
2006 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that rare high-risk CNVs affecting the gene encoding the dopamine transporter contribute to the pathogenesis of schizophrenia and affective disorders.
|
26559242 |
2016 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To examine the effect of a polymorphism in the dopamine transporter gene (the variable number of tandem repeats in the 3' untranslated region) on brain function during executive processing in healthy volunteers and patients with schizophrenia.
|
19884604 |
2009 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
No associations were found between the DRD3 and DAT polymorphisms and schizophrenia.
|
14681904 |
2004 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Thus, our results do not support an association of the SLC6A3 VNTR with schizophrenia in our sample.
|
15608954 |
2004 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In this study, we investigated the pharmacogenetic correlates of SLC6A3 and response to risperidone treatment in 130 Chinese schizophrenia patients.
|
17979508 |
2007 |