|
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
However, DAT protein was significantly increased in putatively treatment-resistant cases of schizophrenia compared to putatively treatment-responsive cases.
|
28094812 |
2017 |
|
Schizophrenia
|
0.600 |
Biomarker
|
disease |
MGD |
Anterior pituitary hypoplasia and dwarfism in mice lacking the dopamine transporter.
|
9247269 |
1997 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The promoter region of the DAT1 gene may play a role in increasing susceptibility to schizophrenia, but does not affect the severity of psychotic symptoms in Han Chinese.
|
19879111 |
2010 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Because mutations of the dopamine transporter gene might underlie the cause of schizophrenia in a subset of families, we undertook a linkage analysis between schizophrenia in 9 families and a dopamine transporter gene polymorphism.
|
8406521 |
1993 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Considering the cumulative evidence from six case-control studies and results from additional family-based studies, it seems unlikely that the 40-base-pair VTNR polymorphism of the SLC6A3 gene influences risk for schizophrenia.
|
15567077 |
2005 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Dopamine transporter (DAT) genetic hypofunction in mice produces alterations consistent with ADHD but not schizophrenia or bipolar disorder.
|
28454982 |
2017 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We investigated the relationship between several functional polymorphisms in genes coding for dopamine metabolism and transport enzymes (MAO-A VNTR; MAO-A 941T>G; DAT VNTR; DAT -67A/T; CYP2D6*3; CYP2D6*4; CYP2D6*5; CYP2D6*6) and the frequency of schizophrenia.
|
20041956 |
2010 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We have therefore tried to find other single nucleotide polymorphisms (SNPs) in DAT1 gene and to use them as additional markers for the association study of schizophrenia.
|
15380858 |
2004 |
|
Schizophrenia
|
0.600 |
Biomarker
|
disease |
CTD_human |
[Striatal dopamine transporter density decrease in first episode schizophrenic patients treated with risperidone].
|
16762269 |
2006 |
|
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Identification of the mRNA expression status of the dopamine D2 receptor and dopamine transporter in peripheral blood lymphocytes of schizophrenia patients.
|
24086483 |
2013 |
|
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
The genes for the dopamine transporter (DAT) and the D-Amino acid oxidase activator (DAOA or G72) have been independently implicated in the risk for schizophrenia and in bipolar disorder and/or their related intermediate phenotypes.
|
22438288 |
2013 |
|
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
We present a schizophrenia association study using an extensive linkage disequilibrium (LD) mapping approach in seven candidate genes with a well established link to dopamine, including receptors (DRD2, DRD3) and genes involved in its metabolism and transport (ACE, COMT, DAT, MAO-A, MAO-B).
|
19508883 |
2009 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
As impaired serotonergic and dopaminergic neurotransmission is implicated in the pathogenesis of depression and schizophrenia this study sought to investigate the putative association between several functional gene polymorphisms (SERT 5-HTTLPR, MAO-A VNTR, COMT Val158Met and DAT VNTR) and schizophrenia.
|
28416295 |
2017 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The authors assessed the linkage between this gene and schizophrenia spectrum disorders by using polymorphic dopamine transporter gene markers in 156 subjects from 16 multiplex pedigrees with schizophrenia as well as schizophreniform, schizoaffective, and schizotypal disorders and mood-incongruent psychotic depression.
|
7802105 |
1995 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We previously detected association between SZ and intronic SLC6A3 variants that replicated in two independent Caucasian samples, but had no obvious function.
|
20957647 |
2010 |
|
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
An attractive model to study processes related to neurodevelopment in schizophrenia is reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) and differentiating them into different neuronal lineages. iPSCs from three schizophrenia patients and from two controls were reprogrammed from hair follicle keratinocytes, because of their accessibility and common ectodermal origin with neurons. iPSCs were differentiated into Pax6(+)/Nestin(+) neural precursors and then further differentiated into β3-Tubulin(+)/tyrosine hydroxylase(+)/DAT(+) dopaminergic neurons.
|
23732879 |
2013 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In this study, we examined whether single nucleotide polymorphisms (SNPs) in SLC6A3, SLC6A4 were associated with schizophrenia in Han Chinese people (893 schizophrenia patients and 611 healthy controls).
|
25019689 |
2014 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
No significant differences in age at onset of psychotic symptoms, attention task performance or family loading for schizophrenia spectrum disorders were observed between groups with different DRD3 and DAT1 genotypes.
|
11104840 |
2001 |
|
Schizophrenia
|
0.600 |
Biomarker
|
disease |
MGD |
Motor behaviour deficits and their histopathological and functional correlates in the nigrostriatal system of dopamine transporter knockout mice.
|
12617953 |
2003 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This study provides evidence that a genetic variant in the DRD2 gene and possible interaction between DRD3 and SLC6A3 genes are associated with schizophrenia.
|
19766158 |
2010 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
For the first time, these findings provide tentative evidence for the contribution of the DAT1 gene core promoter polymorphism to the etiopathophysiology of schizophrenia at least in the Iranian male population that we studied.
|
15274029 |
2004 |
|
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
To fully evaluate SLC6A3 as a therapeutic antipshycotic target we investigated association of the gene with responses to chlorpromazine and clozapine and with chlorpromazine-induced extrapyramidal syndrome (EPS) in the Chinese schizophrenia population.
|
20580759 |
2010 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Two single nucleotide polymorphisms (SNPs) in the DAT1 gene (rs2975223 and rs2455391) were tested in 368 patients with schizophrenia and 420 healthy controls, of whom 293 patients underwent an assessment of psychotic symptoms through the positive and negative syndrome scale (PANSS).
|
22366190 |
2012 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Thus the aim of the present study was to investigate the possible association between a new single nucleotide polymorphism (rs6347) located in exon 9 of the protein transporter (SLC6A3) and schizophrenia.
|
21049181 |
2010 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This first hand evidence, regarding BDNF and DAT1 gene methylation and their expression profile with risk of schizophrenia, indicated a significant function for the BDNF gene in the development of schizophrenia.
|
23065263 |
2012 |