Attention deficit hyperactivity disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Dissociation of impulsivity and aggression in mice deficient for the ADHD risk gene Adgrl3: Evidence for dopamine transporter dysregulation.
|
30849401 |
2019 |
Attention deficit hyperactivity disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The DAT is the molecular target for cocaine and amphetamine as well as a number of pathological conditions including autism spectrum disorders, attention-deficit hyperactivity disorder (ADHD), dopamine transporter deficiency syndrome (DTDS), and Parkinson's disease.
|
30828290 |
2019 |
Attention deficit hyperactivity disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Altered expression of DAT is linked to neurodevelopmental disorders, including attention deficit hyperactivity disorder and autism spectrum disorder, and is shown to contribute to the response of psychotropic drugs and neurotoxicants.
|
31749842 |
2019 |
Attention deficit hyperactivity disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Several lines of evidence indicate that DAT dysfunction is linked to neuropsychiatric disorders such as attention-deficit/hyperactivity disorder (ADHD), bipolar disorder (BPD), and autism spectrum disorder (ASD).
|
30153408 |
2019 |
Attention deficit hyperactivity disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Several meta-analyses showed small but significant association between the 10-repeat allele in the DAT1 gene in 3'-untranslated region variant number tandem repeat polymorphism and child and adolescent ADHD, whereas in adult ADHD the 9-repeat allele was suggested to confer as risk allele.
|
30923918 |
2019 |
Attention deficit hyperactivity disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Dopamine transporter genotype modulates brain activity during a working memory task in children with ADHD.
|
31306870 |
2019 |
Attention deficit hyperactivity disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The dopamine transporter (DAT) has received continuous attention as a potential risk factor for psychiatric disease, as it is critical for dopamine homeostasis and serves as principal target for ADHD medications.
|
29559554 |
2018 |
Attention deficit hyperactivity disorder
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Overall, these findings suggest that peripheral DAT1 promoter methylation may be predictive of striatal DAT availability in adults with ADHD.
|
30033547 |
2018 |
Attention deficit hyperactivity disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
COMT and DAT1 polymorphisms moderate the indirect effect of parenting behavior on youth ADHD symptoms through neurocognitive functioning.
|
28675949 |
2018 |
Attention deficit hyperactivity disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
This work presents a different means (i.e. other than direct blockade by a DAT inhibitor) to regulate the activity of DAT and dopaminergic neurotransmission, and a potential target site for future development of ADHD treatments.
|
30413217 |
2018 |
Attention deficit hyperactivity disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Adults with ADHD had both abnormal DAT availability and P300 amplitude, suggesting that ADHD is linked to dysfunction of the central dopaminergic system and poor cognitive processes related to response selection and execution.
|
28847342 |
2018 |
Attention deficit hyperactivity disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Adolescents with ADHD who showed a robust response to OROS-MPH (n = 7) had significantly greater reduction of DAT density in the right putamen than adolescents who showed less robust response to OROS-MPH (n = 13) (p = 0.02).
|
29684537 |
2018 |
Attention deficit hyperactivity disorder
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
DAT methylation levels were greatly reduced in ADHD patients compared to control, healthy children.
|
28822049 |
2018 |
Attention deficit hyperactivity disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that the DAT1-related GMV alterations in the posterior cortical regions may contribute to visual memory performance in children with ADHD.
|
29433615 |
2018 |
Attention deficit hyperactivity disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis investigated the potential role of SLC6A3 polymorphisms in response to MPH in children with ADHD.
|
29171685 |
2018 |
Attention deficit hyperactivity disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Dopamine transporter (DAT) knockout (KO) and heterozygous (HET) mice, in particular, have been widely used to study ADHD.
|
29520239 |
2018 |
Attention deficit hyperactivity disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our findings provide initial evidence for the involvement of the epigenetic alterations of DAT1 in modulating the response to MPH treatment in ADHD, primarily on oppositional and hyperactive-impulsive symptoms.
|
27676100 |
2017 |
Attention deficit hyperactivity disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
This study supports the idea that being born SGA moderates the effect of the DAT1 gene on ADHD symptoms in the preschool years and may help to explain some of the heterogeneity in ADHD outcomes.
|
28666839 |
2017 |
Attention deficit hyperactivity disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Saikosaponin A Alleviates Symptoms of Attention Deficit Hyperactivity Disorder through Downregulation of DAT and Enhancing BDNF Expression in Spontaneous Hypertensive Rats.
|
28293263 |
2017 |
Attention deficit hyperactivity disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The unique and interactive contributions of a maternal dopamine receptor gene (DAT1), maternal ADHD symptoms (hyperactive- impulsive, inattentive), and home atmosphere to the prediction of ADHD symptoms (hyperactive- impulsive, inattentive) in 7- year-old boys (N = 96) were examined using data from a longitudinal study of familial risk for ADHD.
|
27873141 |
2017 |
Attention deficit hyperactivity disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Amphetamine and methylphenidate are known to have stimulatory effect in healthy subjects but not in humans with attention deficit hyperactivity disorder and in rodents with impaired dopamine transporter (DAT) function.
|
28750831 |
2017 |
Attention deficit hyperactivity disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Dopamine transporter gene (DAT1) has been implicated in attention deficits.
|
28757070 |
2017 |
Attention deficit hyperactivity disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
DAT is the target for psychostimulants-like cocaine and amphetamine-and plays an important role in neuropsychiatric disorders, including attention-deficit hyperactivity disorder and drug addiction.
|
28894302 |
2017 |
Attention deficit hyperactivity disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Given that prenatal exposure to alcohol or smoking is known to affect dopamine-rich brain regions, we hypothesized that individuals carrying the ADHD risk alleles of the dopamine receptor D4 (<i>DRD4</i>) and dopamine transporter (<i>DAT1</i>) genes may be especially sensitive to their effects.
|
28234207 |
2017 |
Attention deficit hyperactivity disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Many neurological disorders such as schizophrenia, bipolar disorder, Parkinson disease and attention-deficit hyperactivity disorder are associated with imbalances in DA homeostasis that may be related to DAT dysfunction.
|
28115272 |
2017 |