|
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Association between serotonin transporter genotype, brain structure and adolescent-onset major depressive disorder: a longitudinal prospective study.
|
25226554 |
2014 |
|
Unipolar Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Down regulation of serotonin transporter (5-HTT) expression has been associated with brain function and major depression.
|
23017007 |
2013 |
|
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association study of serotonin transporter availability and SLC6A4 gene polymorphisms in patients with major depression.
|
23149035 |
2013 |
|
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
The interaction between child maltreatment, adult stressful life events and the 5-HTTLPR in major depression.
|
23618376 |
2013 |
|
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Genome-wide association data provide further support for an association between 5-HTTLPR and major depressive disorder.
|
22921522 |
2013 |
|
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Strong effects of environmental factors on prevalence and course of major depressive disorder are not moderated by 5-HTTLPR polymorphisms in a large Dutch sample.
|
23021380 |
2013 |
|
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Response to citalopram is not associated with SLC6A4 genotype in African-Americans and Caucasians with major depression.
|
23562852 |
2013 |
|
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The objective of this study is to investigate the influence of the 5-HTTLPR (serotonin transporter-linked promoter region), cytochrome P450 2C19, and cytochrome P450 2D6 polymorphisms on escitalopram (ESC) and venlafaxine (VEN) responses in major depressive disorder.
|
24014145 |
2013 |
|
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
49 patients with major depression and SSRI treatment were genotyped for the 5-HTTLPR locus including the rs25531.
|
22086748 |
2012 |
|
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The contribution of BDNF and 5-HTT polymorphisms and early life stress to the heterogeneity of major depressive disorder: a preliminary study.
|
22247094 |
2012 |
|
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
The purpose of this study was to evaluate the association between 5-HTTLPR and clinical response to escitalopram treatment in Korean subjects with major depressive disorder.
|
23095326 |
2012 |
|
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Although the hippocampus is one of the key regions in which neurogenesis occurs, and serotonin plays an important role in neurogenesis, results of studies that investigate effect of the 5-HTTLPR polymorphism on hippocampal volumes in major depressive disorder are inconclusive.
|
20962544 |
2011 |
|
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Influence of 5-HTTLPR polymorphism on resting state perfusion in patients with major depression.
|
20934189 |
2011 |
|
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Interaction of 5-HTTLPR genotype and unipolar major depression in the emergence of aggressive/hostile traits.
|
21492940 |
2011 |
|
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A functional variant of the serotonin transporter gene (5-HTTLPR) has been associated with increased risk for major depression in the context of stress.
|
20360351 |
2011 |
|
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
The role of a functional polymorphism in the transcriptional control region of serotonin transporter gene (5-HTTLPR, SERTPR) has been studied intensively in major depression and in the response to selective serotonin inhibitors (SSRIs) in major depression.
|
20640435 |
2011 |
|
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to determine whether the serotonin transporter gene polymorphism (5-HTTLPR) is associated with the treatment outcomes of escitalopram for patients with comorbid major depression and alcohol dependence.
|
20800901 |
2011 |
|
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
CTD_human |
Estradiol and progesterone modify the effects of the serotonin reuptake transporter polymorphism on serotonergic responsivity to citalopram.
|
21843009 |
2011 |
|
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
While further work is needed to identify the actual functional genetic variants involved, these results suggest that a relationship exists between genetic variation in HTR2A and either 5-HTT expression or central serotonergic transmission that influences the therapeutic response to 5-HTT inhibition in major depression.
|
20047709 |
2010 |
|
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Patients with MD and healthy participants were investigated using high-resolution MRI and genotyping for serotonin transporter polymorphism in the promoter region of the serotonin transporter gene (SLC6A4, 5-HTTLPR).
|
20147891 |
2010 |
|
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Meta-analysis indicated evidence of a small but statistically significant association between the 5-HTTLPR polymorphism and unipolar depression [odds ratio (OR) 1.08, 95% confidence interval (CI) 1.03-1.12].
|
20380781 |
2010 |
|
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association between major depressive disorder and a functional polymorphism of the 5-hydroxytryptamine (serotonin) transporter gene: a meta-analysis.
|
20016401 |
2010 |
|
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
252 unrelated Caucasian patients (f = 142; m = 110) with major depression were genotyped for NET and 5-HTT polymorphisms.
|
20588071 |
2010 |
|
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
We first replicated an interaction of child abuse and 5-HTTLPR on lifetime SCID diagnosis of major depression in a subsample (N = 236) of the study population-the largest African-American 5-HTTLPR cohort reported to date.
|
20029939 |
2010 |
|
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The role of clinical variables, neuropsychological performance and SLC6A4 and COMT gene polymorphisms on the prediction of early response to fluoxetine in major depressive disorder.
|
20584552 |
2010 |