Irritable Bowel Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this pilot exploratory study, the primary aim was to determine whether genetic polymorphisms of tryptophan hydroxylase ( TPH1/TPH2), serotonin reuptake transporter ( SERT), or catechol-O-methyltransferase ( COMT) are associated with fatigue in women with IBS.
|
30309244 |
2019 |
Irritable Bowel Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
5-HTTLPR L/L was a risk factor for the co-occurrence of IBS-C among FD patients (OR: 12.47; 95% CI: 2.00-77.75; P = 0.007).
|
28160607 |
2017 |
Irritable Bowel Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
IBS patients with depressive disorders were characterized by higher frequency of 5-HTTLPR L allele in comparison to IBS patients with anxiety disorders.
|
28951738 |
2017 |
Irritable Bowel Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We found no significant associations between rare variants in and around the SERT gene and IBS risk, GI symptom profile, or response to treatment.
|
26912503 |
2016 |
Irritable Bowel Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The exposure of Caco-2 cells to IBS supernatants induced a significant decrease in SERT gene expression, independently of IBS subtypes, compared with AC mucosal supernatants.
|
26744473 |
2016 |
Irritable Bowel Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this article, current insights regarding the regulation of SERT in IBS are provided, including aspects of SERT gene polymorphisms, microRNAs, immunity and inflammation, gut microbiota, growth factors, among others.
|
27688655 |
2016 |
Irritable Bowel Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
The significant difference was shown in D-IBS subjects when compared to the controls (X(2) = 50.850, P<0.0001) for 5-HTTLPR.
|
24392134 |
2014 |
Irritable Bowel Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Different from the conclusions of the earlier meta-analyses, the 5-HTTLPR mutation affects IBS-C but not IBS-D and IBS-M development and this effect only exists in the East Asian population but not other populations.
|
24512255 |
2014 |
Irritable Bowel Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Systemic assessment was performed for the published studies based on the association of SLC6A4 I/S polymorphism and IBS risk from PubMed (Medline), EMBASE search.
|
24069428 |
2013 |
Irritable Bowel Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The role of 5-HTT LPR and GNβ3 825C>T polymorphisms and gene-environment interactions in irritable bowel syndrome (IBS).
|
22855291 |
2012 |
Irritable Bowel Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
SLC6A4 s/s genotype was commoner in D-IBS than C-IBS, A-IBS and controls (p<0.001).
|
22457857 |
2012 |
Irritable Bowel Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Overall, there is limited evidence of a genetic association with IBS; the most frequently studied association is with 5-HTTLPR, and the most replicated association is with TNF superfamily member 15.
|
22403795 |
2012 |
Irritable Bowel Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The role of serotonin transporter (SERT) gene polymorphism in irritable bowel syndrome (IBS) has been demonstrated.
|
22435794 |
2012 |
Irritable Bowel Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
A functional polymorphism in the serotonin transporter (5-HTT), which terminates serotonergic signalling, was also found associated with these psychiatric comorbidities and increased visceral sensitivity in irritable bowel syndrome, which coexistence is associated with higher dyspeptic symptom severity.
|
22014438 |
2011 |
Irritable Bowel Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recently, several genetic studies have suggested that serotonin transporter (SERT) gene polymorphisms and the G-protein β3 (GNβ3) C825T gene polymorphism are associated with FD and IBS.
|
21443700 |
2011 |
Irritable Bowel Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this case-control study, 196 Caucasian Rome II IBS patients [97 IBS-D (aged 18-66 years; 67 female) and 99 IBS-C (aged 18-65 years; 95 female)] and 92 Caucasian healthy volunteers (aged 18-63 years; 60 female) from the UK had genomic DNA extracted from peripheral blood and the 5-HTTLPR and STin2 polymorphisms genotyped.
|
19561511 |
2010 |
Irritable Bowel Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study was to investigate the potential association between the SERT-P polymorphism and clinical subtypes of IBS patients in the Indian population.
|
19687750 |
2010 |
Irritable Bowel Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
We previously reported that the 5-hydroxytryptamine transporter gene-linked polymorphic region (5-HTTLPR) is related to anxiety in subjects with IBS.
|
19426812 |
2009 |
Irritable Bowel Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genetic association studies with IBS symptom phenotype have generally provided inconsistent results for many candidate genes investigated, such as SLC6A4, GNB3, and IL-10.
|
19655247 |
2009 |
Irritable Bowel Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
There were significant associations between post-CLO responses and gene variations for DeltaGV (alpha2A and SLC6A4), rectal sensation of gas (alpha2A, GNbeta3), urgency (alpha2A); and pain (GNbeta3 and SLC6A4); and rectal compliance (SLC6A4). alpha2A, GNbeta3 and SLC6A4 genotypes significantly modify responses to CLO on sensory and motor GI functions in health and IBS.
|
19309415 |
2009 |
Irritable Bowel Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this exploratory study we therefore expanded the search for a possible association of the serotonin transporter with irritable bowel syndrome to include not only the 5-HTTLPR and Stin2 VNTR length polymorphisms, but also the functional single nucleotide polymorphism rs25531.
|
19125330 |
2009 |
Irritable Bowel Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Current data on the efficacy of SSRIs in IBS, association of the SERT gene promoter polymorphism 5-HTTLPR with IBS and the expression pattern of SERT in the intestinal mucosa of IBS patients are conflicting.
|
18550438 |
2008 |
Irritable Bowel Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There were significant associations between 5-HTTLPR SS genotype and absence of IBS symptoms and between 5-HTTLPR LS/SS genotype and increased rectal compliance and increased pain ratings, particularly at 12 and 24 mmHg distensions.
|
18511740 |
2008 |
Irritable Bowel Syndrome
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
This study investigates the association of psychological symptoms with the distribution of two serotonin transporter gene (SERT) polymorphisms, located in the promoter region (5-HTTLPR) and in intron 2 (STin2 VNTR), in patients with irritable bowel syndrome (IBS).
|
17909168 |
2007 |
Irritable Bowel Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study investigates the association of psychological symptoms with the distribution of two serotonin transporter gene (SERT) polymorphisms, located in the promoter region (5-HTTLPR) and in intron 2 (STin2 VNTR), in patients with irritable bowel syndrome (IBS).
|
17909168 |
2007 |