|
Panic Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Epigenetic patterns such as hypermethylation of the serotonin transporter gene (SLC6A4) have been associated with various mental disorders including MDD, but, to date, no association with PD has been reported.
|
31353282 |
2019 |
|
Panic Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this age- and gender-matched case-control study involving 119 PD patients and 119 healthy controls, we examined the genotype distributions and allele frequencies of the serotonin transporter gene linked polymorphic region (5-HTTLPR), -1019C/G (rs6295) promoter polymorphism of the serotonin receptor 1A (5-HT1A), and catechol-O-methyltransferase (COMT) gene polymorphism (rs4680) and their association with PD.
|
28096880 |
2017 |
|
Panic Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The authors examined whether 5-HTTLPR tri-allelic approach and Cathechol-O-methyltransferase (COMT) Val(158)Met polymorphism can predict HRQOL in patients with PD controlling for sociodemographic factors and disorder-related symptom levels.
|
27134498 |
2016 |
|
Panic Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This is a pilot study assessing the impact of polymorphisms of serotonin transporter (5-HTT; 5-HTTLPR (S/L)) and norepinephrine transporter (NET; rs2242446 (T/C)) genes on selective serotonin reuptake inhibitors (SSRIs) and serotonin/norepinephrine reuptake inhibitors (SNRIs) response in Korean panic disorder (PD) patients.
|
26508020 |
2016 |
|
Panic Disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Abnormal serotonin transporter (5-HTT) function and autonomic nervous system (ANS) dysregulation has been proposed in panic disorder.
|
24342768 |
2014 |
|
Panic Disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study could suggest the effect of the interaction between 5-HTTLPR and separation life events on panic disorder and its potential endophenotype.
|
23635830 |
2013 |
|
Panic Disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
We suggest that it is worth pursuing SLC6A4 in nonbladder PD, and ADORA2A and TMEM16B in bladder PD.
|
23018769 |
2012 |
|
Panic Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The present study revealed that plasma concentration of PAX, 5-HTTLPR genotype, -1019C/G 5-HT(1A) genotype, PAS score at baseline, and adverse effects may influence the therapeutic response to PAX in patients with PD.
|
21688171 |
2011 |
|
Panic Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
SLC6A4 provided strong and consistent evidence of association with the PD and PD+SAD groups, with the most significant association in both groups being at rs140701 (chi(2)=10.72, P=0.001 with PD and chi(2)=8.59, P=0.003 in the PD+SAD group).
|
18663369 |
2010 |
|
Panic Disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Panic disorder and serotonergic genes (SLC6A4, HTR1A and HTR2A): Association and interaction with childhood trauma and parenting.
|
20817074 |
2010 |
|
Panic Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The high plasma concentration of PAX, the L/S genotype of 5-HTTLPR, and comorbid physical illness might be associated with a poor response to the initial phase of pharmacotherapy of PD with PAX.
|
19259652 |
2009 |
|
Panic Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our data highlight the importance of defining appropriate phenotypes for psychiatric genetic studies and demonstrate that the 5-HTTLPR genotype may be related to the symptomatic profiles rather than to the vulnerability to develop panic disorder.
|
19683026 |
2009 |
|
Panic Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The objective of this study was to assess the association between the 5-HTTLPR polymorphism in the triallelic system and the neurotic personality traits in patients in PD remission.
|
18164547 |
2008 |
|
Panic Disorder
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
The objective of this study was to assess the association between the 5-HTTLPR polymorphism in the triallelic system and the neurotic personality traits in patients in PD remission.
|
18164547 |
2008 |
|
Panic Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study was to investigate the association between the tryptophan hydroxylase (TPH) gene and a serotonin transporter gene promoter polymorphism (5-HTTLPR), with panic disorder in a Korean population.
|
16822601 |
2006 |
|
Panic Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, paroxetine efficacy in PD seems to be related to allelic variation within the promoter of the 5-HTT gene in female subjects.
|
16034444 |
2005 |
|
Panic Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The objective is to investigate the possible association between four serotonin gene polymorphisms (T102C, A-1438G, 5-HTTLPR and VNTR-5HTT) and panic disorder (PD).
|
15999296 |
2005 |
|
Panic Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
CO2 reactivity of patients with panic disorder seems not to be influenced by the genetic variants of the 5-HTTLPR; this finding does not support a role for the serotonin transporter in the etiopathogenesis of CO2 reactivity in panic disorder.
|
15274038 |
2004 |
|
Panic Disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
The findings support the hypothesis that comorbid panic disorder identifies a genetic subtype of bipolar disorder and suggest a role for COMT and 5-HTT in vulnerability to these disorders.
|
11772685 |
2002 |
|
Panic Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
An analysis of possible synergistic effects of the MAO-A gene promoter variant and the short serotonin transporter (5-HTT) gene promoter variant in panic disorder was performed in a German and an Italian sample (combined panic disorder n = 144, combined controls n = 175).
|
12607224 |
2000 |
|
Panic Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No linkage between the 5-HTT polymorphism and panic disorder was observed in the multiplex families, using a variety of simulations for dominant and recessive models of inheritance.
|
10335545 |
1999 |