|
Stress, Psychological
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Life stress increases risk for developing post-traumatic stress disorder (PTSD), and more prominently so in short-allele carriers of the serotonin transporter linked polymorphic region (5-HTTLPR).
|
29233642 |
2018 |
|
Stress, Psychological
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Further research is necessary to understand how early life stress interacts with 5-HTT genotypes to confer risk for suicidal behavior through psychological mechanisms.
|
28890225 |
2017 |
|
Stress, Psychological
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Although, early life stress has been shown to alter the composition of the gut microbiota, it is not known whether a lower 5-HTT expression is also associated with an altered microbiome composition.
|
28824378 |
2017 |
|
Stress, Psychological
|
0.100 |
Biomarker
|
disease |
BEFREE |
While SLC6A4 hypermethylation has typically been described to be independently associated with both early life stress and depressive disorders, only a few papers address whether methylation could mediate the interaction between stress and 5-HTTLPR in predicting psychopathological risk.
|
27880876 |
2017 |
|
Stress, Psychological
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Caspi et al.'s 2003 report that 5-HTTLPR genotype moderates the influence of life stress on depression has been highly influential but remains contentious.
|
27515846 |
2016 |
|
Stress, Psychological
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although 5-HTTLPR has been shown to influence the risk of life stress-induced depression in the majority of studies, others have produced contradictory results, possibly due to weak effects and/or sample heterogeneity.
|
25747798 |
2015 |
|
Stress, Psychological
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Simultaneously, the migrants were also happier if people in their country of origin had a higher frequency of 5-HTT long allele, a genotype known to be associated with resilience under life stresses.
|
24532702 |
2015 |
|
Stress, Psychological
|
0.100 |
Biomarker
|
disease |
BEFREE |
The serotonin transporter (SERT) gene-linked polymorphic region (5-HTTLPR) has been implicated in moderating the link between life stress and depression.
|
24937096 |
2014 |
|
Stress, Psychological
|
0.100 |
Biomarker
|
disease |
BEFREE |
5-HTTLPR modulated the relationship between early life stress and the core features of bipolar illness.
|
25219494 |
2014 |
|
Stress, Psychological
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to test whether a specific serotonin transporter (5HTT) gene polymorphism interacting with life stress increased the risk of depression in patients with epilepsy.
|
25173097 |
2014 |
|
Stress, Psychological
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Taken together, shorter leukocyte TL is significantly associated with the 5-HTTLPR S/S allelic variant, which may be implicated in psychological stress-related health problems.
|
24710073 |
2014 |
|
Stress, Psychological
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The contribution of BDNF and 5-HTT polymorphisms and early life stress to the heterogeneity of major depressive disorder: a preliminary study.
|
22247094 |
2012 |
|
Stress, Psychological
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To use data gathered over the course of a 30-year longitudinal study of a New Zealand birth cohort to test the hypothesis that the presence of short ('s') alleles of 5-HTTLPR are associated with an increased response to life stress.
|
21282783 |
2011 |
|
Stress, Psychological
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that both 5-HTTLPR and BDNF Val66Met moderate the relationship between life stress and rumination.
|
21745335 |
2011 |
|
Stress, Psychological
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Because the effects of the 5-HTTLPR polymorphism on amygdala reactivity are also conditional on self-reported life stress, differences in life stress exposure may account for this apparent discrepancy.
|
21246665 |
2011 |
|
Stress, Psychological
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We hypothesized that peripheral blood mononuclear cell (PBMC) DNA methylation within an 800 bp cytosine-phosphate-guanosine (CpG) island that overlaps with the 5-HTT transcription initiation start site, a hypothesized model of the same genomic region in brain tissue, would mediate or moderate the effects of early life stress and a functional 5-HTT promoter polymorphism (rh5-HTTLPR) on two outcomes: PBMC 5-HTT expression and behavioral stress reactivity.
|
20398062 |
2010 |
|
Stress, Psychological
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recent reports of a moderating effect of a genetic polymorphism (5-HTTLPR) in the serotonin transporter protein gene on the likelihood that life stress will precipitate depression may help to understand the development of mood symptoms in medical interns.
|
20368500 |
2010 |
|
Stress, Psychological
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here we report an intrinsic immunobiological difference between individuals carrying two short (SS) versus long (LL) 5-HTTLPR alleles, that is observed in healthy subjects reporting low exposure to life stress.
|
19883751 |
2010 |
|
Stress, Psychological
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Human observational studies have shown that, in interaction with life stress, the short or S-allele of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) is associated with an enhanced risk for depression.
|
20881788 |
2010 |
|
Stress, Psychological
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Visual perspective for positive memories was independently predicted by both harm avoidance and a gene by environment interaction between the 5-HTTLPR polymorphism and life stress exposure.
|
19423361 |
2009 |
|
Stress, Psychological
|
0.100 |
Biomarker
|
disease |
BEFREE |
Lower 5-HTT BP(P) may represent a biological pathway through which early life stress predisposes to the development of subsequent psychiatric illness, including major depressive disorder.
|
19288578 |
2009 |
|
Stress, Psychological
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These subjects had been genotyped for 5-HTT-LPR Short allele versus LL homozygote status, and completed the early life stress scale, and recording of startle responses and heart rate for conscious and nonconscious fear conditions.
|
19446647 |
2009 |
|
Stress, Psychological
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recent studies on life stress, depression, and polymorphisms in the promoter region of the serotonin transporter gene (5-HTTLPR) are characterized by powerful genetic techniques, but are also characterized by unconventional and inconsistent approaches to assessing life stress.
|
19000200 |
2008 |
|
Stress, Psychological
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the Mannheim Study of Risk Children, which followed a cohort of n = 384 from birth to adolescence, the association of 5-HTTLPR with harm avoidance and internalising problems was examined, including gender and early life stress as possible moderators.
|
17051418 |
2007 |
|
Stress, Psychological
|
0.100 |
Biomarker
|
disease |
BEFREE |
Following a reductionistic path that leads from gene-behavior association studies to neuroimaging and epigenetic studies, we compare two models of 5-HTT-dependent modulation of brain activity and discuss the role of life stress experience in modifying 5-HTT function in the brain.
|
17726476 |
2007 |