SLC6A4, solute carrier family 6 member 4, 6532

N. diseases: 440; N. variants: 28
Disease: Rectal sensation ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0232717
Disease: Rectal sensation
Rectal sensation 		0.010 Biomarker phenotype BEFREE There were significant associations between post-CLO responses and gene variations for DeltaGV (alpha2A and SLC6A4), rectal sensation of gas (alpha2A, GNbeta3), urgency (alpha2A); and pain (GNbeta3 and SLC6A4); and rectal compliance (SLC6A4). alpha2A, GNbeta3 and SLC6A4 genotypes significantly modify responses to CLO on sensory and motor GI functions in health and IBS. 19309415 2009