SLC6A4, solute carrier family 6 member 4, 6532

N. diseases: 440; N. variants: 28
Disease: Anxiety and fear ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0424139
Disease: Anxiety and fear
Anxiety and fear 		0.030 Biomarker disease BEFREE Genetic variation of the serotonin transporter (SCL6A4, 5-HTT) has been associated with fear- and anxiety-related behaviors, while a polymorphism in exon III of the D4 dopamine receptor gene (DRD4) has been linked to novelty seeking. 20001112 2009
CUI: C0424139
Disease: Anxiety and fear
Anxiety and fear 		0.030 Biomarker disease BEFREE Genetic variation of the serotonin transporter (5-HTT) has been associated with fear- and anxiety-related behaviours. 18925984 2009
CUI: C0424139
Disease: Anxiety and fear
Anxiety and fear 		0.030 GeneticVariation disease BEFREE These results demonstrate genetically driven variation in the response of brain regions underlying human emotional behavior and suggest that differential excitability of the amygdala to emotional stimuli may contribute to the increased fear and anxiety typically associated with the short SLC6A4 allele. 12130784 2002