|
Autism Spectrum Disorders
|
0.300 |
Biomarker
|
disease |
BEFREE |
Differential serotonin transporter (5-HTT) and 5-HT<sub>2</sub> receptor density in limbic and neocortical areas of adults and children with autism spectrum disorders: implications for selective serotonin reuptake inhibitor efficacy.
|
31325179 |
2019 |
|
Autism Spectrum Disorders
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
For girls, maternal peritraumatic dissociation levels in combination with the 5-HTTLPR LS or SS genotype were associated with higher ASD traits.
|
30394245 |
2019 |
|
Autism Spectrum Disorders
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Aspects of these findings were also evident with another naturally occurring C-terminal SERT coding variant identified in our ASD study, Asn605.
|
30668912 |
2019 |
|
Autism Spectrum Disorders
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our findings support ongoing p38α MAPK activity as an important determinant of the physiological and behavioral perturbations of SERT Ala56 mice and, more broadly, supports consideration of p38α MAPK inhibition as a potential treatment for core and comorbid phenotypes present in ASD subjects.
|
30297392 |
2018 |
|
Autism Spectrum Disorders
|
0.300 |
Biomarker
|
disease |
BEFREE |
Similarly, maternal Slc6a4 knock-out and prenatal stress in rodents results in offspring demonstrating ASD-like characteristics.
|
28821725 |
2017 |
|
Autism Spectrum Disorders
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Altered amygdala-sACC coupling based on 5-HTTLPR genotype may help explain some of the heterogeneity in neural and social function observed in ASD.
|
28088648 |
2017 |
|
Autism Spectrum Disorders
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Event related potentials (ERPs) to happy, fearful, and neutral expressions were collected from neurotypical adults (n=25) and adults with ASD (n=27)-of whom 32 had short and 13 had homozygous long SLC6A4 alleles.
|
27178863 |
2016 |
|
Autism Spectrum Disorders
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Genetic linkage and association studies of both whole blood serotonin levels and of ASD risk point to the chromosomal region containing the serotonin transporter (SERT) gene in males but not in females.
|
26577932 |
2016 |
|
Autism Spectrum Disorders
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Expression of the most common SERT variant (Ala56) in mice increases 5-HT clearance and causes ASD-like behaviors.
|
27111230 |
2016 |
|
Autism Spectrum Disorders
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
In both samples, mothers of children with ASD carrying the stress susceptible short allele variant of 5-HTTLPR experienced a greater number of stressors and greater stress severity when compared to mothers carrying the long allele variant.
|
27091118 |
2016 |
|
Autism Spectrum Disorders
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Quantitative transmission disequilibrium test demonstrated significant genetic effect of STin2 allele as well as STin2/3'UTR-SNP and 5-HTTLPR/3'UTR-SNP haplotypes on 5-HT levels, but no direct association with overall CARS score and ASD phenotype.
|
25261775 |
2015 |
|
Autism Spectrum Disorders
|
0.300 |
Biomarker
|
disease |
BEFREE |
Previous studies have identified SLC6A4 and HTR2A associations with SSRI response in patients with depression and 5-HTTLPR (SLC6A4) associations with escitalopram response in ASD.
|
26262902 |
2015 |
|
Autism Spectrum Disorders
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
5-HTTLPR genotype influences amygdala habituation to sad faces differently for individuals with ASD vs controls.
|
23526151 |
2014 |
|
Autism Spectrum Disorders
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The 5-HTTLPR/rs25531 polymorphism or its correlates may modulate severity of ADHD and ASD symptoms in children with ASD, but in different ways.
|
23123360 |
2013 |
|
Autism Spectrum Disorders
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our findings indicate that FGA and SLC6A4 gene interactions may contribute to the phenotypes of ASD rather than the incidence of ASD.
|
24192574 |
2013 |
|
Autism Spectrum Disorders
|
0.300 |
Biomarker
|
disease |
BEFREE |
Furthermore, multiple studies have now reported gene-gene interaction between the integrin β3 and SERT genes in association with ASD.
|
21254450 |
2011 |
|
Autism Spectrum Disorders
|
0.300 |
Biomarker
|
disease |
BEFREE |
A promoter-linked insertion/deletion polymorphism of the serotonin transporter gene (SLC6A4) has been implicated in autism spectrum disorders (ASDs) in numerous family based association studies.
|
21302342 |
2011 |
|
Autism Spectrum Disorders
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
MAOA, DBH, and SLC6A4 variants in CHARGE: a case-control study of autism spectrum disorders.
|
21538940 |
2011 |
|
Autism Spectrum Disorders
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
A total of 110 adult patients with ASD (n=61) or ADHD (n=49) with or without a lifetime history of SUD participated in a study in which we genotyped polymorphisms in five known candidate genes for (one of) the disorders, i.e. the 5HTTLPR in SLC6A4/5-HTT, rs1800497 (TaqIA C>T) in DRD2, rs7794745 in CNTNAP2, rs1843809 in TPH2, and rs6565113 in CDH13.
|
20446882 |
2010 |
|
Autism Spectrum Disorders
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
5-HTTLPR polymorphism influences prefrontal neurochemical metabolites in autism spectrum disorder.
|
20619617 |
2010 |
|
Autism Spectrum Disorders
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Additionally, this study suggested a role of the 5-HTTLPR and environmental factors in the clinical expression of ASD.
|
19281802 |
2009 |
|
Autism Spectrum Disorders
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
These results do not support a significant role for rare coding variants in SLC6A4 in autism spectrum disorders, nor do they support a significant role for SLC6A4 in rigid-compulsive traits in these disorders.
|
19360675 |
2008 |
|
Autism Spectrum Disorders
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
With regard to the transmission of 5-HTTLPR, the long allelic variant was preferentially transmitted in the ASD subjects.
|
17280648 |
2007 |
|
Autism Spectrum Disorders
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
No allelic HLA or 5-HTTLPR polymorphisms were specifically associated with ASD, suggesting these loci as markers of other genes mapped in their close proximity that may be more directly involved and thus may merit further analytical studies.
|
16698432 |
2006 |
|
Autism Spectrum Disorders
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Genotyping data obtained from the 2 mM magnesium protocol increased the significance of linkage and gave suggestive (P=0.06) association with autism spectrum disorder, whereas the corrected genotypes of 5-HTTLPR provide no linkage information beyond the results we have previously published and no evidence of association with autism spectrum disorder.
|
16395127 |
2006 |