|
NEUROTICISM
|
0.100 |
Biomarker
|
disease |
BEFREE |
Neuroticism mediated the relation between 5-HTTLPR and nostalgia proneness.
|
29210327 |
2019 |
|
NEUROTICISM
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Using structural equation modeling (SEM), the 5-HTTLPR long-form had a direct positive association with the 5-HTT mRNA level and an indirect adverse relationship with the 5-HTT mRNA level through neuroticism and previous suicide attempts.
|
29957477 |
2018 |
|
NEUROTICISM
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Gender-specific association between serotonin transporter polymorphisms (5-HTTLPR and rs25531) and neuroticism, anxiety and depression in well-defined healthy Han Chinese.
|
27788383 |
2017 |
|
NEUROTICISM
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Neuroticism and genetic variation in the serotonin-transporter (SLC6A4) and catechol-O-methyltransferase (COMT) gene are risk factors for psychopathology.
|
27743374 |
2017 |
|
NEUROTICISM
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These findings provide novel evidence for both independent and interactive effects of 5-HTTLPR genotype and neuroticism on amygdala communication, which may mediate effects on risk for mood and affective disorders.
|
26245837 |
2016 |
|
NEUROTICISM
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The presented data implies that 5-HTTLPR/rs25531 variants and neuroticism are linked by resting state functional connectivity of amygdala and fusiform gyrus and suggests that variants of 5-HTTLPR/rs25531 genotype and different levels of neuroticism may partly account for altered processing of negative facial emotions.
|
24874919 |
2015 |
|
NEUROTICISM
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Although high neuroticism was significantly related to a higher frequency of stressful life events and daily hassles, it did not interact with the 5-HTTLPR genotype on general past sleep quality.
|
25644221 |
2015 |
|
NEUROTICISM
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A functional polymorphism (5-hydroxytryptamine transporter linked polymorphic region [5-HTTLPR]) in the promoter region of human serotonin transporter gene has been found to be associated with several dimensions of neuroticism and psychopathology, especially anxiety.
|
25833281 |
2015 |
|
NEUROTICISM
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A functional polymorphism (5-HTTLPR) within the serotonin transporter gene (SERT) has been associated with personality dimensions such as neuroticism, with emotional reactivity to negative events, and with an increased risk of affective disorders.
|
25711941 |
2015 |
|
NEUROTICISM
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim was to examine the influence of repeated Trp administration on stress responsiveness and emotional eating in homozygous 5-HTTLPR S-allele (N=60) and L-allele (N=58) carriers with high and low neuroticism.
|
24845181 |
2014 |
|
NEUROTICISM
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
FH+ subjects with the gain-of-function 5-HTTLPR genotype scored higher in neuroticism, harm avoidance, and symptoms of depression (p-values ≤ 0.03).
|
24796636 |
2014 |
|
NEUROTICISM
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Although the serotonin transporter length polymorphic region (5-HTTLPR) polymorphism is an extensively-investigated genetic marker of anxiety related personality traits (neuroticism and harm avoidance) and affective disorders, effect sizes in meta-analyses are small, if present at all, and all available primary studies to date lack mandatory statistical power.
|
24438559 |
2014 |
|
NEUROTICISM
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Examination influenced appetite for particular sweet snacks differently depending on 5-HTTLPR genotype and neuroticism.
|
24630938 |
2014 |
|
NEUROTICISM
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mediation analysis suggested that the presence of the 5-HTTLPR short allele decreased real life measures of financial risk taking through its influence on neuroticism.
|
23382929 |
2013 |
|
NEUROTICISM
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Only the low-allele expressing (S) 5-HTTLPR carriers showed vulnerability to depression exclusively when they also reported exposure to high-impact events and showed high neuroticism.
|
23492930 |
2013 |
|
NEUROTICISM
|
0.100 |
Biomarker
|
disease |
BEFREE |
We tested this hypothesis in 357 subjects who were genotyped for the 5-HTTLPR and provided self-reports of neuroticism, life-satisfaction and LEs.
|
22420614 |
2012 |
|
NEUROTICISM
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Findings of the current study do not support a role for singular or interactive effects of the 5-HTTLPR genotype and trait neuroticism on affective and physiological reactivity to a 35% CO₂ inhalation procedure.
|
22209359 |
2012 |
|
NEUROTICISM
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
For ODD, children with the short allele of the 5HTT promoter polymorphism had higher neuroticism and ODD symptoms regardless of level of self-blame in relation to inter-parental conflict, whereas children without this allele had more ODD symptoms only in the context of more self-blame for inter-parental conflict.
|
22584505 |
2012 |
|
NEUROTICISM
|
0.100 |
Biomarker
|
disease |
BEFREE |
The interaction of 5-HTTLPR by neuroticism was assessed on BMI.
|
22955839 |
2012 |
|
NEUROTICISM
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Affective and neuroendocrine stress reactivity to an academic examination: influence of the 5-HTTLPR genotype and trait neuroticism.
|
21683756 |
2011 |
|
NEUROTICISM
|
0.100 |
Biomarker
|
disease |
BEFREE |
We found that 5-HTTLPR LL carriers scored lower on neuroticism in the presence of the BDNF Val variant, but scored higher on neuroticism in the presence of the BDNF Met variant.
|
20042999 |
2010 |
|
NEUROTICISM
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A combination of variants in 5-HTTLPR and environmental stress seems to increase neuroticism in healthy individuals.
|
19822181 |
2010 |
|
NEUROTICISM
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Meta-analyses evaluating the association between the serotonin transporter polymorphism (5-HTTLPR) with neuroticism and depression diagnosis as phenotypes have been inconclusive.
|
20455953 |
2010 |
|
NEUROTICISM
|
0.100 |
Biomarker
|
disease |
BEFREE |
We studied a healthy non-clinical sample (N=118) to determine whether the 5-HTTLPR interacts with current life events in predicting neuroticism.
|
20573579 |
2010 |
|
NEUROTICISM
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Neuroticism has been linked to a functional polymorphism in the serotonin transporter gene (5-HTTLPR), with short-allele carriers being overrepresented among high-scorers on neuroticism.
|
20440524 |
2010 |