|
Von Willebrand disease, platelet type
|
0.060 |
Biomarker
|
disease |
BEFREE |
Platelet-type von Willebrand disease (vWD) is a congenital bleeding disorder characterized by heightened ristocetin-induced platelet aggregation caused by abnormally high affinity between the platelet membrane glycoprotein (GP) Ib/IX complex and von Willebrand factor (vWF).
|
9226170 |
1997 |
|
Bernard-Soulier Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Bernard-Soulier syndrome (BSS) is a rare inherited bleeding disorder which is caused by a qualitative or quantitative abnormality of the platelet glycoprotein (GP) Ib/IX/V complex.
|
9432024 |
1997 |
|
Retinoblastoma
|
0.080 |
Biomarker
|
disease |
BEFREE |
pRb2/p130: a new candidate for retinoblastoma tumor formation.
|
16936755 |
2006 |
|
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
pRb2/p130, a member of the Retinoblastoma gene family, has been shown to be a powerful prognostic factor in several malignancies.
|
18676747 |
2008 |
|
Malignant neoplasm of stomach
|
0.010 |
Biomarker
|
disease |
BEFREE |
pRb2/p130 localizes to the cytoplasm in diffuse gastric cancer.
|
25205458 |
2015 |
|
Stomach Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
pRb2/p130 localizes to the cytoplasm in diffuse gastric cancer.
|
25205458 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
pRb2/p130 is a key tumor suppressor, whose oncosuppressive activity has mainly been attributed to its ability to negatively regulate cell cycle by interacting with the E2F4 and E2F5 transcription factors.
|
25205458 |
2015 |
|
von Willebrand Disease, Type 2A
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
C1272S: a new candidate mutation in type 2A von Willebrand disease that disrupts the disulfide loop responsible for the interaction of VWF with platelet GP Ib-IX.
|
14755371 |
2004 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
A careful analysis of pRb2/p130 expression in tumor specimens could help to identify the best clinical protocol to be used for each patient, improving efficacy and tolerance and therefore offering additional progress in the treatment of advanced ovarian cancer.
|
15585644 |
2004 |
|
Bernard-Soulier Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
A defective platelet glycoprotein (GP) Ib/IX/V complex [von Willebrand factor (VWF) receptor] results in Bernard-Soulier syndrome (BSS), which is characterized by macrothrombocytopenia and impaired ristocetin- and thrombin-induced platelet aggregation.
|
23414566 |
2013 |
|
Macrothrombocytopenia
|
0.030 |
Biomarker
|
disease |
BEFREE |
A defective platelet glycoprotein (GP) Ib/IX/V complex [von Willebrand factor (VWF) receptor] results in Bernard-Soulier syndrome (BSS), which is characterized by macrothrombocytopenia and impaired ristocetin- and thrombin-induced platelet aggregation.
|
23414566 |
2013 |
|
Pancreatic carcinoma
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303.
|
22142827 |
2012 |
|
Pancreatic carcinoma
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303.
|
22142827 |
2012 |
|
Von Willebrand disease, platelet type
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
A limited number of mutations within the glycoprotein Ib-IX complex have been described that permit a structurally altered receptor to interact with soluble von Willebrand factor, and this is the molecular basis of platelet-type von Willebrand disease.
|
18187573 |
2008 |
|
Tumor Cell Invasion
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
A multivariate analysis demonstrated that pRb2/p130 expression (P= 0.026), venous invasion (P= 0.028), and TNM stage (P= 0.044) were independent prognostic indicators in patients with esophageal SCCs.
|
12474056 |
2002 |
|
Carcinoma of lung
|
0.040 |
Biomarker
|
disease |
BEFREE |
A scope for this review is to examine some of the gene delivery systems mostly used, discussing their weaknesses and strengths, and to discuss the role of pRb2/p130 in lung cancer.
|
10741694 |
2000 |
|
Malignant neoplasm of lung
|
0.030 |
Biomarker
|
disease |
BEFREE |
A scope for this review is to examine some of the gene delivery systems mostly used, discussing their weaknesses and strengths, and to discuss the role of pRb2/p130 in lung cancer.
|
10741694 |
2000 |
|
Primary malignant neoplasm of lung
|
0.030 |
Biomarker
|
disease |
BEFREE |
A scope for this review is to examine some of the gene delivery systems mostly used, discussing their weaknesses and strengths, and to discuss the role of pRb2/p130 in lung cancer.
|
10741694 |
2000 |
|
Von Willebrand disease, platelet type
|
0.060 |
Biomarker
|
disease |
BEFREE |
Although the platelet glycoprotein (GP) Ib/IX complex is known to constitute the platelet's ristocetin-dependent receptor for vWF, a unique structural abnormality within this complex has not previously been identified in PT-vWD.
|
2052556 |
1991 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Among the three family members, the retinoblastoma-related gene product pRb2/p130 is a tumor suppressor gene and an effective candidate target for gene therapy approach.
|
11029489 |
2000 |
|
Bernard-Soulier Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
An absent platelet glycoprotein (GP) Ib-IX receptor results in the Bernard-Soulier syndrome and is characterized by severe bleeding and the laboratory presentation of macrothrombocytopenia.
|
12200373 |
2002 |
|
Macrothrombocytopenia
|
0.030 |
Biomarker
|
disease |
BEFREE |
An absent platelet glycoprotein (GP) Ib-IX receptor results in the Bernard-Soulier syndrome and is characterized by severe bleeding and the laboratory presentation of macrothrombocytopenia.
|
12200373 |
2002 |
|
Blood Coagulation Disorders
|
0.090 |
GeneticVariation
|
group |
BEFREE |
Bernard Soulier Syndrome (BSS) is a rare inherited bleeding disorder caused by a defect in the glycoprotein (GP)Ib/IX/V complex.
|
11297032 |
2001 |
|
Thrombocytopenia
|
0.030 |
GeneticVariation
|
phenotype |
BEFREE |
Bernard-Soulier syndrome (BSS) is a congenital bleeding disorder characterised by thrombocytopenia, giant platelets and decreased platelet adhesion resulting from genetic alterations of the glycoprotein (GP) Ib/IX/V complex.
|
26044173 |
2015 |
|
Macrothrombocytopenia
|
0.030 |
Biomarker
|
disease |
BEFREE |
Bernard-Soulier syndrome (BSS) is a hereditary macrothrombocytopenia caused by defects in the glycoprotein (GP) Ib-IX-V complex.
|
31352676 |
2019 |