|
Bernard-Soulier Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Bernard-Soulier syndrome (BSS) is a hereditary macrothrombocytopenia caused by defects in the glycoprotein (GP) Ib-IX-V complex.
|
31352676 |
2019 |
|
Pancreatic carcinoma
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study.
|
28470677 |
2017 |
|
Bernard-Soulier Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Bernard-Soulier syndrome (BSS) is a congenital bleeding disorder characterised by thrombocytopenia, giant platelets and decreased platelet adhesion resulting from genetic alterations of the glycoprotein (GP) Ib/IX/V complex.
|
26044173 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
pRb2/p130 is a key tumor suppressor, whose oncosuppressive activity has mainly been attributed to its ability to negatively regulate cell cycle by interacting with the E2F4 and E2F5 transcription factors.
|
25205458 |
2015 |
|
Bernard-Soulier Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
A defective platelet glycoprotein (GP) Ib/IX/V complex [von Willebrand factor (VWF) receptor] results in Bernard-Soulier syndrome (BSS), which is characterized by macrothrombocytopenia and impaired ristocetin- and thrombin-induced platelet aggregation.
|
23414566 |
2013 |
|
Bernard-Soulier Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Platelets from BSS patients are typically defective in surface expression of glycoprotein (GP)Ib-IX-V, a platelet-specific adhesion-signaling complex, composed of GPIbα disulfide linked to GPIbβ, and noncovalently associated with GPIX and GPV.
|
23929303 |
2013 |
|
Bernard-Soulier Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
The hallmark of BSS is an abnormal platelet attachment to the vessel wall due to reduced or abnormal glycoprotein Ib/IX/V complex.
|
22343686 |
2012 |
|
Bernard-Soulier Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Bernard-Soulier syndrome (BSS) is an inherited bleeding disorder caused by a defect in the platelet glycoprotein (GP) Ib-IX-V complex.
|
22044935 |
2012 |
|
Bernard-Soulier Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Bernard-Soulier syndrome (BSS) is an inherited bleeding disorder caused by a defect in the platelet glycoprotein (GP) Ib/IX complex.
|
23143686 |
2012 |
|
Pancreatic carcinoma
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303.
|
22142827 |
2012 |
|
Pancreatic carcinoma
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303.
|
22142827 |
2012 |
|
Bernard-Soulier Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Bernard-Soulier syndrome (BSS) is an extremely rare (1:1 million) bleeding disorder of platelet adhesion, caused by defects in the glycoprotein (GP)Ib/IX/V complex.
|
21699652 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The RB (pRb2/p16) and p53 (p14/p53/p21) tumor-suppressor pathways in endemic Burkitt lymphoma.
|
21127431 |
2011 |
|
Bernard-Soulier Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Bernard-Soulier syndrome (BSS) is a severe inherited bleeding disorder that is caused by a defect in glycoprotein (GP)Ib-IX-V complex, the platelet membrane receptor for von Willebrand factor.
|
17083647 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our results support the hypothesis that platelet GP Ib-IX functions that support normal hemostasis or pathologic thrombosis also contribute to tumor malignancy.
|
17494758 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumor suppressor pRb2/p130 gene and its derived product Spa310 spacer domain as perspective candidates for cancer therapy.
|
17708530 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The retinoblastoma family members--pRb, pRb2/p130 and p107--are tumor suppressor genes involved in controlling four major cellular processes: growth arrest, apoptosis, differentiation and angiogenesis.
|
16936751 |
2006 |
|
Bernard-Soulier Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Bernard-Soulier syndrome (BSS) is a rare inherited bleeding disorder due to quantitative or qualitative abnormalities in the platelet glycoprotein (GP) Ib/IX/V complex, the major von Willebrand factor receptor.
|
15609295 |
2005 |
|
Bernard-Soulier Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Bernard-Soulier Syndrome (BSS) is a severe congenital platelet disorder that results from a deficiency of the platelet membrane glycoprotein (GP) Ib/IX complex that is composed of four subunits (GPIbalpha, GPIbbeta, GPIX, and GPV).
|
15550031 |
2004 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
A careful analysis of pRb2/p130 expression in tumor specimens could help to identify the best clinical protocol to be used for each patient, improving efficacy and tolerance and therefore offering additional progress in the treatment of advanced ovarian cancer.
|
15585644 |
2004 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Immunohistochemical analysis revealed loss or decrease of pRb2/p130 expression in 18 cases (40%). pRb2/p130 expression was mostly nuclear and inversely correlated to the tumor grade (P < 0.05).
|
15131049 |
2004 |
|
Bernard-Soulier Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
An absent platelet glycoprotein (GP) Ib-IX receptor results in the Bernard-Soulier syndrome and is characterized by severe bleeding and the laboratory presentation of macrothrombocytopenia.
|
12200373 |
2002 |
|
Bernard-Soulier Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Bernard-Soulier Syndrome (BSS) is an autosomal recessive bleeding disorder due to quantitative or qualitative abnormalities in the glycoprotein (GP) Ib/IX/V complex, the platelet receptor for von Willebrand factor.
|
12463594 |
2002 |
|
Bernard-Soulier Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Bernard-Soulier syndrome (BSS) is an autosomal recessive bleeding disorder caused by quantitative or qualitative abnormalities in the glycoprotein (GP) Ib/IX/V complex, the platelet receptor for von Willebrand factor.
|
12447957 |
2002 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The survival rate of patients with esophageal SCCs expressing pRb2/p130 was significantly better than that of patients with tumors without pRb2/p130 expression (P= 0.016).
|
12474056 |
2002 |