Respiratory Distress Syndrome, Newborn
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
CONCLUSIONS SP-A (+186A/G) and SP-B (1580C/T) polymorphisms are strongly associated with the risk of RDS in preterm infants.
|
28011976 |
2016 |
Respiratory Distress Syndrome, Newborn
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Overall, the SP-A1 6A4 or/and SP-A2 1A5 haplotype was present in 20 newborns with RDS (35.7%), resulting in a 4.2-fold (1.60-11.0) higher probability of RDS in carriers.
|
27835691 |
2016 |
Respiratory Distress Syndrome, Newborn
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Homozygosity of SP-A (OR 46, 95% CI 14-151) and SP-B (OR 5.2, 95% CI 2.3-11.4) alleles increased the risk of respiratory distress syndrome.
|
26061924 |
2015 |
Respiratory Distress Syndrome, Newborn
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We have identified associations between specific variants of the SP-A genes and RDS risk in the Korean preterm study population.
|
23038062 |
2013 |
Respiratory Distress Syndrome, Newborn
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To determine whether haplotypes of SP-A and SP-D are transmitted disproportionately from parents to offspring with RDS, we hypothesized that previously unstudied genetic haplotypes of these SP genes are associated with the development of RDS.
|
17524024 |
2007 |
Respiratory Distress Syndrome, Newborn
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The main SP-A haplotype, interactively with SP-B Ile131Thr polymorphism and with constitutional and environmental factors, influences the risk of RDS.
|
17142161 |
2006 |
Respiratory Distress Syndrome, Newborn
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Single-nucleotide polymorphisms (SNPs) in SP-A1 and SP-A2, genes encoding SP-A, have been associated with susceptibility to respiratory distress syndrome, COPD, and pulmonary infections.
|
16162765 |
2005 |
Respiratory Distress Syndrome, Newborn
|
0.100 |
Biomarker
|
disease |
BEFREE |
Surfactant protein (SP-A, -B, -C and -D) gene variations may play a role in both BPD and RDS.
|
15102713 |
2004 |
Respiratory Distress Syndrome, Newborn
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The SP-A 6A2 allele in the SP-B Thr131 background predisposed the smallest singleton infants to RDS, whereas near-term multiples were protected from RDS.
|
12947025 |
2003 |
Respiratory Distress Syndrome, Newborn
|
0.100 |
Biomarker
|
disease |
BEFREE |
The difference in RDS concordance rates between the monozygotic (MZ) and dizygotic (DZ) twin pairs as evidence of a genetic influence was evaluated, and the SP-A and SP-B genes were investigated for potential associations with the susceptibility to RDS.
|
12483294 |
2003 |
Respiratory Distress Syndrome, Newborn
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The main SP-A1 allele 6A2 (P = 0.030), genotype 6A2/6A2 (P = 0.0042) and haplotype 6A2-1A(0) (P = 0.016) were over-represented in healthy premature twin infants compared to RDS twins.
|
12952021 |
2003 |
Respiratory Distress Syndrome, Newborn
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Specific alleles of the SP-A and SP-B genes associate interactively with susceptibility to respiratory distress syndrome.
|
12667827 |
2003 |
Respiratory Distress Syndrome, Newborn
|
0.100 |
Biomarker
|
disease |
BEFREE |
Both SP-A and SP-B associate with susceptibility to RDS.
|
12537318 |
2002 |
Respiratory Distress Syndrome, Newborn
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Allelic variations of the SP-A and SP-B genes have been shown to be important genetic determinants in individual susceptibility to RDS, which is a good general model for a multifactorial pulmonary disease resulting from complex interactions between several environmental and genetic factors.
|
12452477 |
2002 |
Respiratory Distress Syndrome, Newborn
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The present family study provides strong support for a direct or indirect role of the SP-A alleles as genetic predisposers to RDS in premature infants.
|
11702216 |
2001 |
Respiratory Distress Syndrome, Newborn
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Among the infants born before 32 weeks of gestation and having the SP-B genotype Thr/Thr, the SP-A1 allele 6A(2) was over-represented in RDS group compared with controls (P = 0.001, OR = 4.7, CI 1.8-12.2).
|
11063734 |
2000 |
Respiratory Distress Syndrome, Newborn
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We show that certain SP-A1 alleles (6A2 and 6A3) and an SP-A1/SP-A2 haplotype (6A2/1A0) were associated with RDS.
|
10762543 |
2000 |
Respiratory Distress Syndrome, Newborn
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
SP-A and SP-B polymorphisms are found at a higher frequency in certain groups of patients with respiratory distress syndrome (RDS), and SP-B mutations are linked to the pathogenesis of congenital alveolar proteinosis (CAP).
|
9558469 |
1998 |
Respiratory Distress Syndrome, Newborn
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of pulmonary surfactant protein A (SP-A) gene and respiratory distress syndrome: interaction with SP-B.
|
9475280 |
1998 |
Respiratory Distress Syndrome, Newborn
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, one SP-A2 allele (1A0) shown to associate with low SP-A mRNA levels is found with higher frequency in a subgroup with respiratory distress syndrome.
|
9813381 |
1998 |