SLC8A1, solute carrier family 8 member A1, 6546

N. diseases: 146; N. variants: 24
Disease: Cardiac Arrhythmia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003811
Disease: Cardiac Arrhythmia
Cardiac Arrhythmia 		0.050 AlteredExpression phenotype BEFREE The inhibitory effect of rosmarinic acid on overexpression of NCX1 and stretch- induced arrhythmias after acute myocardial infarction in rats. 29710544 2018
CUI: C0003811
Disease: Cardiac Arrhythmia
Cardiac Arrhythmia 		0.050 Biomarker phenotype BEFREE Triple threat: the Na+/Ca2+ exchanger in the pathophysiology of cardiac arrhythmia, ischemia and heart failure. 21291388 2011
CUI: C0003811
Disease: Cardiac Arrhythmia
Cardiac Arrhythmia 		0.050 GeneticVariation phenotype BEFREE These could include atrial-selective ion channels (e.g. atrial I(Na), I(Kur) and I(K,ACh)), pathology-selective ion channels (constitutively active I(K,ACh), TRP channels), ischemia-uncoupled gap junctions, proteins related to malfunctioning intracellular Ca2+ homeostasis (e.g., "leaky" ryanodine receptors, overactive Na+, Ca2+ exchanger) or risk factors for arrhythmias ("upstream" therapies). 20624425 2010
CUI: C0003811
Disease: Cardiac Arrhythmia
Cardiac Arrhythmia 		0.050 AlteredExpression phenotype BEFREE In humans, elevated Na/Ca exchanger expression/activity is linked with pathophysiological conditions including arrhythmia and heart failure. 17178715 2007
CUI: C0003811
Disease: Cardiac Arrhythmia
Cardiac Arrhythmia 		0.050 GeneticVariation phenotype BEFREE Our data demonstrate that the n-3 PUFAs significantly suppress cardiac I(NCX1), which is probably one of their protective effects against lethal arrhythmias. 15358223 2004