SLC8A1, solute carrier family 8 member A1, 6546

N. diseases: 146; N. variants: 24
Disease: Congestive heart failure ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.290 Biomarker disease BEFREE NRG-1β treatment could partially prevent the decrease of Cav1.2 and SERCA2a, and the increase of NCX1 in HF rats. 31281251 2019
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.290 Biomarker disease BEFREE Dysregulation of NCX1 is observed in end-stage human heart failure. 28755400 2017
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.290 AlteredExpression disease BEFREE NCX1 full-length protein and a 75-kDa NCX1 fragment along with calpain were up-regulated in aortic stenosis patients and rats with heart failure. 25336645 2014
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.290 Biomarker disease BEFREE Both α-adrenergic receptor (α-AR) and β-adrenergic receptor (β-AR) signaling can play a role in the regulation of calcium homeostasis in the cardiomyocyte, but chronic activation in periods of cardiac stress contributes to heart failure by mechanisms which include Ncx1 upregulation. 23224875 2013
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.290 AlteredExpression disease BEFREE Notably, the expression of the Na/Ca exchanger (NCX1), targeted by EHD3 in heart is similarly elevated in HF. 22406195 2012
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.290 Biomarker disease BEFREE Triple threat: the Na+/Ca2+ exchanger in the pathophysiology of cardiac arrhythmia, ischemia and heart failure. 21291388 2011
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.290 Biomarker disease RGD Angiotensin-converting enzyme inhibitor improves force and Ca2 +--frequency relationships in myocytes from rats with heart failure. 17536604 2007
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.290 AlteredExpression disease BEFREE In humans, elevated Na/Ca exchanger expression/activity is linked with pathophysiological conditions including arrhythmia and heart failure. 17178715 2007
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.290 Biomarker disease BEFREE Female homozygous transgenic mice that overexpress NCX1 develop heart failure and die prematurely after two or more pregnancies. 12502568 2002
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.290 AlteredExpression disease BEFREE Is myocardial Na+/Ca2+ exchanger transcription a marker for different stages of myocardial dysfunction? Quantitative polymerase chain reaction of the messenger RNA in endomyocardial biopsies of patients with heart failure. 10898440 2000