|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Thirty-five primary human cultures enriched in CR-CSCs, including four from chemoresistant metastatic lesions, were used for in vitro studies and to generate CR-CSC-based mouse avatars to evaluate tumor growth and progression upon treatment with BMP7v alone or in combination with standard therapy or PI3K inhibitors.
|
31591478 |
2020 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
High expression of BMP7 was found to be significantly associated with better prognosis in both estrogen receptor (ER)‑positive (ER+) (P<0.001) and ER‑negative (ER‑) tumors (P<0.001), whereas high expression of BMP6 was associated with better prognosis only in ER+ tumors (P=0.004); it was associated with worse prognosis in ER‑ tumors (P=0.006).
|
31524275 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
BMP7 induces the transcription factor Snail to promote astrocytic differentiation in GSCs and suppress tumor growth in vivo.
|
29449696 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A xenograft tumor model and histological evaluation were introduced to detect the effects of ORI and BMP7 in SW620 cells in vivo.
|
30132514 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, Restoration of BMP7 remarkably reversed the tumor suppressive effects of miR-137 on NSCLC cell proliferation, migration, and invasion.
|
26617798 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Data from xenografts confirmed reduced and delayed tumor formation for animals treated with BMP7-loaded microspheres.
|
25860932 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The stem cell master regulator SOX2 was increased by NSAIDs (p<0.01), as well as the tumor suppressor miR-630 (p<0.01), while BMP7, a marker for poor prognosis in CRC, was downregulated by NSAID (indomethacin, p<0.02).
|
25340937 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our results showed that the high expression of BMP7 in HCC was related to tumor size (p < 0.001), histological differentiation (p = 0.041), serum AFP (p = 0.007), and tumor stage (p < 0.001).
|
23179403 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In summary, our results show that BMP-7 is expressed at the highest level in advanced castration-resistant PCa cells and that the inhibitory effects of BMP-7 are dependent on the differentiation status of PCa cells and the tumor microenvironment.
|
20126477 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
BMP7 expression level was assessed in a cohort of human lung cancer samples (tumour, n=70; matched normal tissues, n=70), in association with patient clinical variables, using quantitative analysis of BMP7.
|
20530416 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
COL11A2 overexpression and BMP7 underexpression could collaborate to OS tumor growth, through its central role in bone remodeling process.
|
20225287 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Overexpression of hTERT lengthens telomeres and blocks BMP7-induced tumor growth arrest.
|
19010887 |
2008 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Stable expression of K18Y-TATI in HT-29 5M21 cells downregulated tumor growth, angiogenesis and the expression of several metastasis-related genes, including CSPG4 (13.8-fold), BMP-7 (9.7-fold), the BMP antagonist CHORDIN (5.2-fold), IGFBP-2 and IGF2 (9.6- and 4.6-fold).
|
18317448 |
2008 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
BMP7 expression was dependent on the tumor subtype; 57% of the lobular carcinomas but only 37% of the ductal carcinomas were BMP7 positive (P = 0.0001).
|
17895257 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Collectively, our observations suggest that BMP7 controls and preserves the epithelial phenotype in the human prostate and underscore a decisive role of the tumor microenvironment in mediating the therapeutic response of BMP7.
|
17724140 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, BMP7 may represent a novel therapeutic molecule for repression of tumor growth in uveal melanoma.
|
17962434 |
2007 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Evidence for the upregulation of osteogenic protein-1 mRNA expression in musculoskeletal neoplasms.
|
9565067 |
1998 |