|
Malignant neoplasm of prostate
|
0.370 |
Biomarker
|
disease |
BEFREE |
Bone morphogenetic protein 7 (BMP7), a member of the BMP family of signaling molecules, has been implicated in various types of cancer, particularly prostate cancer and breast cancer.
|
30015928 |
2018 |
|
Malignant neoplasm of prostate
|
0.370 |
Biomarker
|
disease |
BEFREE |
In this review, the role of BMPs, particularly that of BMP7, in breast and prostate cancer will be discussed.
|
20166979 |
2010 |
|
Malignant neoplasm of prostate
|
0.370 |
AlteredExpression
|
disease |
BEFREE |
Our results show that BMP-7 is expressed in metastatic PCa and its levels are increased in castration-resistant PCa versus androgen-dependent PCa, whereas the expression of BMP-7 is decreased in primary PCa versus normal prostate.
|
20126477 |
2010 |
|
Malignant neoplasm of prostate
|
0.370 |
Biomarker
|
disease |
CTD_human |
Further validation of candidate genes on a separate cohort of low and high grade prostate cancers by quantitative MethyLight analysis has allowed us to confirm DNA hypermethylation of HOXD3 and BMP7, two genes that may play a role in the development of high grade tumours.
|
19283074 |
2009 |
|
Malignant neoplasm of prostate
|
0.370 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, BMP7 expression in prostate cancer cell lines was inversely related to tumorigenic and metastatic potential in vivo and significantly correlated to E-cadherin/vimentin ratios.
|
17724140 |
2007 |
|
Malignant neoplasm of prostate
|
0.370 |
Biomarker
|
disease |
CTD_human |
Identification of genes potentially involved in the acquisition of androgen-independent and metastatic tumor growth in an autochthonous genetically engineered mouse prostate cancer model.
|
17013881 |
2007 |
|
Malignant neoplasm of prostate
|
0.370 |
Biomarker
|
disease |
BEFREE |
The loss of endogenous BMP-7 from prostate cancer cells is associated with increased invasiveness and motility, which appears to be facilitated by changes in the level of the BMP antagonists noggin and follistatin.
|
17644136 |
2007 |
|
Malignant neoplasm of prostate
|
0.370 |
PosttranslationalModification
|
disease |
BEFREE |
Bone morphogenetic protein 7 protects prostate cancer cells from stress-induced apoptosis via both Smad and c-Jun NH2-terminal kinase pathways.
|
16618753 |
2006 |
|
Malignant neoplasm of prostate
|
0.370 |
AlteredExpression
|
disease |
BEFREE |
We investigated the expression of BMP-7 and -6 in normal and metastatic bone tissues to clarify the biological relationship between the expression of BMPs and bone metastasis in prostatic cancer.
|
12539225 |
2003 |
|
Prostatic Neoplasms
|
0.330 |
AlteredExpression
|
group |
BEFREE |
Bone morphogenetic protein 7 is expressed in prostate cancer metastases and its effects on prostate tumor cells depend on cell phenotype and the tumor microenvironment.
|
20126477 |
2010 |
|
Prostatic Neoplasms
|
0.330 |
Biomarker
|
group |
CTD_human |
Discovery of novel hypermethylated genes in prostate cancer using genomic CpG island microarrays.
|
19283074 |
2009 |
|
Prostatic Neoplasms
|
0.330 |
Biomarker
|
group |
CTD_human |
Identification of genes potentially involved in the acquisition of androgen-independent and metastatic tumor growth in an autochthonous genetically engineered mouse prostate cancer model.
|
17013881 |
2007 |
|
Prostatic Neoplasms
|
0.330 |
AlteredExpression
|
group |
LHGDN |
Overexpression of noggin inhibits BMP-mediated growth of osteolytic prostate cancer lesions.
|
16126463 |
2006 |
|
Prostatic Neoplasms
|
0.330 |
AlteredExpression
|
group |
BEFREE |
Screening of breast and prostate tumors revealed a similar association with osteogenic protein-1 mRNA expression.
|
9565067 |
1998 |
|
Pulmonary Fibrosis
|
0.320 |
Biomarker
|
disease |
BEFREE |
In conclusion, the pulmonary fibrosis induced by silica in rats was significantly reduced by treatment with BMP-7-BMSCs and BMSCs.
|
28062213 |
2017 |
|
Pulmonary Fibrosis
|
0.320 |
Biomarker
|
disease |
BEFREE |
Therefore, we test the hypothesis that EMT contributes to silica-induced pulmonary fibrosis and BMP-7 inhibits EMT in silica-induced pulmonary fibrosis.
|
25733726 |
2016 |
|
Pulmonary Fibrosis
|
0.320 |
Therapeutic
|
disease |
CTD_human |
Gremlin-mediated decrease in bone morphogenetic protein signaling promotes pulmonary fibrosis.
|
17975199 |
2008 |
|
Unipolar Depression
|
0.310 |
Biomarker
|
disease |
PSYGENET |
Low gene expression of bone morphogenetic protein 7 in brainstem astrocytes in major depression.
|
21896235 |
2012 |
|
Unipolar Depression
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
Low gene expression of bone morphogenetic protein 7 in brainstem astrocytes in major depression.
|
21896235 |
2012 |
|
Major Depressive Disorder
|
0.310 |
Biomarker
|
disease |
BEFREE |
BMP7 has unique developmental and trophic actions on catecholamine neurons and these findings suggest that reduced astrocyte support for pontine LC neurons may contribute to pathology of brain noradrenergic neurons in MDD.
|
21896235 |
2012 |
|
Major Depressive Disorder
|
0.310 |
Biomarker
|
disease |
PSYGENET |
BMP7 has unique developmental and trophic actions on catecholamine neurons and these findings suggest that reduced astrocyte support for pontine LC neurons may contribute to pathology of brain noradrenergic neurons in MDD.
|
21896235 |
2012 |
|
Endometriosis
|
0.300 |
Biomarker
|
disease |
CTD_human |
Molecular evidence for differences in endometrium in severe versus mild endometriosis.
|
21063030 |
2011 |
|
Endometrioma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Molecular evidence for differences in endometrium in severe versus mild endometriosis.
|
21063030 |
2011 |
|
Alveolitis, Fibrosing
|
0.300 |
Therapeutic
|
disease |
CTD_human |
Gremlin-mediated decrease in bone morphogenetic protein signaling promotes pulmonary fibrosis.
|
17975199 |
2008 |
|
Bone Resorption
|
0.300 |
Therapeutic
|
phenotype |
CTD_human |
Bisphosphonate rescue in distraction osteogenesis: a case series.
|
17513972 |
2007 |