SLC9A3, solute carrier family 9 member A3, 6550

N. diseases: 58; N. variants: 4
Disease: Colitis ×
Source: BEFREE ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009319
Disease: Colitis
Colitis 		0.020 Biomarker disease BEFREE To test whether microbiome fostered in an NHE3-deficient environment is able to drive mucosal immune responses affecting the onset or severity of colitis, we performed a series of cohousing experiments and fecal microbiome transplants into germ-free Rag-deficient or IL-10<sup>-/-</sup> mice. 29875400 2018
CUI: C0009319
Disease: Colitis
Colitis 		0.020 Biomarker disease BEFREE We previously reported a strong decrease in the NHERF family member PDZK1 (NHERF3), which binds to NHE3 and regulates its function in a mouse model of colitis. 25271043 2015