SLC9A3, solute carrier family 9 member A3, 6550

N. diseases: 58; N. variants: 4
Disease: Congestive heart failure ×
Source: BEFREE ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.030 AlteredExpression disease BEFREE RDN had no significant effects on the protein expression of kidney NHE3 in both Sham and CHF rats. 31490733 2019
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.030 Biomarker disease BEFREE Several possible mechanisms centered around upregulation of sodium-hydrogen exchanger-3 (NHE3) may form a causal link between right ventricular dysfunction, splanchnic congestion, and worsening heart failure. 30640740 2019
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.030 Biomarker disease BEFREE Drugs used to treat diabetes mellitus may favorably affect the pathophysiological mechanisms of heart failure by inhibiting either or both NHE isoforms, and drugs used to treat heart failure may have beneficial effects on glucose tolerance and the complications of diabetes mellitus by interfering with the actions of NHE1 and NHE3. 29038209 2017