SLC9A3, solute carrier family 9 member A3, 6550

N. diseases: 58; N. variants: 4
Disease: Severe diarrhea ×
Source: BEFREE ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1443924
Disease: Severe diarrhea
Severe diarrhea 		0.010 Biomarker phenotype BEFREE Cholera toxin (CT) causes severe diarrhea by increasing intracellular cAMP leading to a PKA-dependent increase in Cl<sup>-</sup> secretion through CFTR and decreased Na<sup>+</sup> absorption through inhibition of Na<sup>+</sup>/H<sup>+</sup> exchanger 3 (NHE3; also known as SLC9A3). 30030371 2018