|
Hepatitis B
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants in the regulatory region of SLC10A1 are not associated with the risk of hepatitis B virus infection and clearance.
|
27491457 |
2016 |
|
Hepatitis B
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To determine the variability/conservation of the domain of hepatitis B virus (HBV) preS1 region that interacts with sodium-taurocholate cotransporting polypeptide (hereafter, NTCP-interacting domain) and the prevalence of the rs2296651 polymorphism (S267F, NTCP variant) in a Spanish population.
|
29456407 |
2018 |
|
Hepatitis B
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The study highlighted the role of the SLC10A1 S267F variant in the loss of the ability to support HBV infection and taurocholate transport activity.
|
31177598 |
2019 |
|
Hepatitis B
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A genetic variant of the NTCP gene is associated with HBV infection status in a Chinese population.
|
26968990 |
2016 |
|
Hepatitis B
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Viral and host predictors of relapse were evaluated, including hepatitis B virus (HBV) surface antigen (HBsAg) level, anti-HBV core antibody level, and presence of single-nucleotide polymorphisms in the genes encoding the receptors NTCP (rs2296651) and CTLA4 (rs231775) and in the 3' untranslated regions of the genes encoding HLA-DPA1 (rs3077) and HLA-DPB1 (rs9277535); posttherapy predictors of relapse were also investigated.
|
29300980 |
2018 |
|
Hepatitis B
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Lack of Ser267Phe variant of sodium taurocholate cotransporting polypeptide among Moroccans regardless of hepatitis B virus infection status.
|
28125961 |
2017 |
|
Hepatitis B
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study investigated the association of the functional polymorphism c.800C>T (rs2296651" genes_norm="6554">p.S267F) (rs2296651) of the NTCP gene with HBV infection.
|
24735529 |
2014 |
|
Hepatitis B
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We conclude that genetic variation at the SLC10A1 locus is not likely a major risk factor of persistent HBV infection among Southern Chinese.
|
28429786 |
2017 |
|
Hepatitis B
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The S267F variant for the HBV cell-entry receptor NTCP was associated with increased resistance to HBV infection and decreased risk for cirrhosis and liver cancer among those with chronic HBV infection.
|
29905807 |
2018 |
|
Hepatitis B
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Analysis of Hepatitis B Virus Reactivation After Radiotherapy in Patients With Hepatocellular Carcinoma Using the Lyman NTCP Model.
|
31526114 |
2019 |
|
Hepatitis B
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
NTCP gene polymorphisms may be associated with the natural course of HBV infection in a Chinese Han population.
|
29205714 |
2018 |
|
Hepatitis B
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Therefore, this study aimed to investigate the association of NTCP polymorphisms with HBV natural course in humans.
|
25010264 |
2014 |
|
Hepatitis B
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We found that genetic variation in the HBV receptor gene (NTCP) was significantly associated with a decreased risk of HBV infection in Taiwanese women.
|
29660219 |
2018 |
|
Hepatitis B
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the S267F variant of NTCP is clinically associated with a lower risk of chronic HBV infection and cirrhosis development, which implicates suppressing HBV entry could reduce the disease burden.
|
29247233 |
2017 |
|
Hepatitis B
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that NTCP mutants contribute to the susceptibility of HBV infection or HBV-related HCC.
|
29285260 |
2017 |
|
Hepatitis B
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Expression levels of several genes involved in HBV infection, including the sodium taurocholate cotransporting polypeptide (NTCP) gene, were gradually elevated as the differentiation status of human iPS cells proceeded to iPS-HLCs.
|
28374759 |
2017 |
|
Hepatitis B
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The S267F variant on the NTCP gene is inversely associated with the chronicity of HBV infection, progression to cirrhosis and hepatocellular carcinoma in East Asian populations.
|
28635613 |
2018 |
|
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Analysis of Hepatitis B Virus Reactivation After Radiotherapy in Patients With Hepatocellular Carcinoma Using the Lyman NTCP Model.
|
31526114 |
2019 |
|
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The NTCP S267F variant of the SLC10A1 gene exhibits protective effects against HBV and HDV infection and is associated with a reduced risk of developing to advanced stages of LC and HCC.
|
30685591 |
2019 |
|
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The rs2296651 (S267F) variant on NTCP (SLC10A1) is inversely associated with chronic hepatitis B and progression to cirrhosis and hepatocellular carcinoma in patients with chronic hepatitis B.
|
26642861 |
2016 |
|
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that NTCP mutants contribute to the susceptibility of HBV infection or HBV-related HCC.
|
29285260 |
2017 |
|
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The S267F variant on the NTCP gene is inversely associated with the chronicity of HBV infection, progression to cirrhosis and hepatocellular carcinoma in East Asian populations.
|
28635613 |
2018 |
|
Hepatitis D Infection
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
The mutation S267F, corresponding to a single nucleotide polymorphism (SNP) found in about 9% of the East Asian population, renders NTCP without either taurocholate transporting activity or the ability to support HBV or HDV infection in cell culture.
|
24390325 |
2014 |
|
Hepatitis D Infection
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
The p.Ser267Phe (S267F) variant of NTCP is a single nucleotide polymorphism (SNP) previously found to cause substantial loss of ability to support HBV and HDV infection and its taurocholic acid uptake function in vitro.
|
30032030 |
2018 |
|
Hepatitis D Infection
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, amino acid position 158 of NTCP/Ntcp is sufficient to discriminate between the HBV/HDV susceptible group of humans and great apes (158G) and the non-susceptible group of Old World monkeys (158R).
|
29912972 |
2018 |