Hepatitis B
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our assay method does not require HBV infection or radioactive <sup>3</sup>H-TCA and provides a facile way to identify viral entry inhibitors via measuring bile acid transport activity of NTCP.
|
31722821 |
2020 |
Hepatitis B
|
0.400 |
Biomarker
|
disease |
BEFREE |
Human NTCP transgenic mouse still could not support productive HBV infection, and humanized mouse liver with human hepatocytes which supported whole HBV life cycle still dominates HBV infection in vivo, a value but expensive model until now.
|
31741335 |
2020 |
Hepatitis B
|
0.400 |
Biomarker
|
disease |
BEFREE |
Additionally, NTCP located in the hepatocyte membrane is the portal for hepatitis B and D virus (HBV/HDV) infections.
|
31140111 |
2020 |
Hepatitis B
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Sodium taurocholate cotransporting polypeptide (NTCP) is expressed at the surface of human hepatocytes and functions as an entry receptor of hepatitis B virus (HBV).
|
31836663 |
2020 |
Hepatitis B
|
0.400 |
Biomarker
|
disease |
BEFREE |
Evolution of Hepatitis B Virus Receptor NTCP Reveals Differential Pathogenicities and Species Specificities of Hepadnaviruses in Primates, Rodents, and Bats.
|
30541833 |
2019 |
Hepatitis B
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In addition, HBV DNA level was suppressed when anti-HBV medicine Entecavir (ETV) introduced into HepG2-NTCP 3D system.
|
30963688 |
2019 |
Hepatitis B
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The study highlighted the role of the SLC10A1 S267F variant in the loss of the ability to support HBV infection and taurocholate transport activity.
|
31177598 |
2019 |
Hepatitis B
|
0.400 |
Biomarker
|
disease |
BEFREE |
Moreover, the aa 158 sequence determined attachment of the HBV envelope protein to the host cell, demonstrating the mechanism whereby HBV infection would create positive selection at this NTCP residue.
|
30541857 |
2019 |
Hepatitis B
|
0.400 |
Biomarker
|
disease |
BEFREE |
Identification of sodium taurocholate cotransporting polypeptide (NTCP) as an entry receptor for hepatitis B and D viruses (HBV and HDV) has not only promoted our understanding of the mechanism underlying the viral entry process, but also provided cell culture models supporting viral infection.
|
30809790 |
2019 |
Hepatitis B
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here, we modified synthetic lipid-based nanoparticles with targeting peptides derived from the hepatitis B virus large envelope protein (HBVpreS) to specifically target the sodium-taurocholate cotransporting polypeptide (NTCP; <i>SLC10A1</i>) on the sinusoidal membrane of hepatocytes.
|
31333191 |
2019 |
Hepatitis B
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Analysis of Hepatitis B Virus Reactivation After Radiotherapy in Patients With Hepatocellular Carcinoma Using the Lyman NTCP Model.
|
31526114 |
2019 |
Hepatitis B
|
0.400 |
Biomarker
|
disease |
BEFREE |
Sodium taurocholate cotransporting polypeptide (NTCP) is a host cell receptor required for hepatitis B virus (HBV) entry.
|
30952782 |
2019 |
Hepatitis B
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We recently found that human hepatoma cell line Li23-derived cells overexpressing NTCP (A8 cells subcloned from Li23 cells), whose gene expression profile was distinct from that of HepG2/NTCP cells, were also sensitive to HBV infection.
|
31133379 |
2019 |
Hepatitis B
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this study, down-regulation of cell membrane localized NTCP expression in proliferating hepatocytes was found to prevent HBV infection in HepG2-NTCP-tet cells and in liver-humanized mice.
|
31179847 |
2019 |
Hepatitis B
|
0.400 |
Biomarker
|
disease |
BEFREE |
Human NTCP as well as the Ntcps from the great apes chimpanzee and orangutan showed transport-competing binding of HBV derived myr-preS1-peptides.
|
29912972 |
2018 |
Hepatitis B
|
0.400 |
Biomarker
|
disease |
BEFREE |
The functional role of sodium taurocholate cotransporting polypeptide NTCP in the life cycle of hepatitis B, C and D viruses.
|
30097692 |
2018 |
Hepatitis B
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results indicated that fasiglifam only affect on HBV infection via NTCP inhibition.
|
29723527 |
2018 |
Hepatitis B
|
0.400 |
Biomarker
|
disease |
BEFREE |
Moreover, exogenous treatment of AA inhibits HBV infection in HepG2-NTCP cells.
|
29437960 |
2018 |
Hepatitis B
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To determine the variability/conservation of the domain of hepatitis B virus (HBV) preS1 region that interacts with sodium-taurocholate cotransporting polypeptide (hereafter, NTCP-interacting domain) and the prevalence of the rs2296651 polymorphism (S267F, NTCP variant) in a Spanish population.
|
29456407 |
2018 |
Hepatitis B
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recently, sodium taurocholate cotransporting polypeptide (NTCP), a liver-specific bile acid transporter, was identified as a bona fide receptor for hepatitis B virus (HBV) and its satellite virus, hepatitis delta virus (HDV).
|
30050063 |
2018 |
Hepatitis B
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our findings uncover a novel role for NTCP in the HBV life cycle and provide a reference for the use of novel NTCP-targeting entry inhibitors to suppress HBV infection and replication.
|
30459339 |
2018 |
Hepatitis B
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Viral and host predictors of relapse were evaluated, including hepatitis B virus (HBV) surface antigen (HBsAg) level, anti-HBV core antibody level, and presence of single-nucleotide polymorphisms in the genes encoding the receptors NTCP (rs2296651) and CTLA4 (rs231775) and in the 3' untranslated regions of the genes encoding HLA-DPA1 (rs3077) and HLA-DPB1 (rs9277535); posttherapy predictors of relapse were also investigated.
|
29300980 |
2018 |
Hepatitis B
|
0.400 |
Biomarker
|
disease |
BEFREE |
The HepG2-NTCP cells expressing the sodium taurocholate cotransporting polypeptide (NTCP) receptor are susceptible to HBV infection.
|
30275764 |
2018 |
Hepatitis B
|
0.400 |
Biomarker
|
disease |
BEFREE |
This study advances our understanding of NTCP-mediated HBV infection.
|
30032030 |
2018 |
Hepatitis B
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
To further improve cell culture systems of HBV infection and replication, we constructed NTCP-expressing HepG2 and AML12 cell lines that are highly permissive to HBV infection.
|
30232184 |
2018 |