Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.370 GeneticVariation disease LHGDN Variations in the VMAT1 gene might affect transporter function and/or expression, and might be involved in the etiology of SZ. 18451639 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.370 GeneticVariation disease BEFREE Variations in the VMAT1 gene might affect transporter function and/or expression and might be involved in the etiology of BPD and/or SZ. 16936705 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.370 GeneticVariation disease BEFREE The gene encoding the vesicular monoamine transporter 1 (VMAT1/SLC18A1) maps to chromosome 8p21, a region where several linkage peaks overlap between schizophrenia, bipolar disorder and anxiety-related personality traits. 18249496 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.370 GeneticVariation disease BEFREE Variations in the VMAT1 gene might affect transporter function and/or expression, and might be involved in the etiology of SZ. 18451639 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.370 GeneticVariation disease BEFREE Furthermore, several recent genetic case-control studies have documented an association between common missense variations in the VMAT1 gene and susceptibility to bipolar disorder and schizophrenia. 20419435 2010
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.320 GeneticVariation disease BEFREE Molecular genetics and developmental studies have identified 21 genes in this region (ADRA1A, ARHGEF10, CHRNA2, CHRNA6, CHRNB3, DKK4, DPYSL2, EGR3, FGF17, FGF20, FGFR1, FZD3, LDL, NAT2, NEF3, NRG1, PCM1, PLAT, PPP3CC, SFRP1 and VMAT1/SLC18A1) that are most likely to contribute to neuropsychiatric disorders (schizophrenia, autism, bipolar disorder and depression), neurodegenerative disorders (Parkinson's and Alzheimer's disease) and cancer. 19204725 2009
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.320 GeneticVariation disease BEFREE Our results may contribute to the evidence indicating an association between the VMAT1 gene and structural brain alterations in depression. 28408293 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.320 GeneticVariation disease BEFREE Our results may contribute to the evidence indicating an association between the VMAT1 gene and structural brain alterations in depression. 28408293 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.320 GeneticVariation disease BEFREE Molecular genetics and developmental studies have identified 21 genes in this region (ADRA1A, ARHGEF10, CHRNA2, CHRNA6, CHRNB3, DKK4, DPYSL2, EGR3, FGF17, FGF20, FGFR1, FZD3, LDL, NAT2, NEF3, NRG1, PCM1, PLAT, PPP3CC, SFRP1 and VMAT1/SLC18A1) that are most likely to contribute to neuropsychiatric disorders (schizophrenia, autism, bipolar disorder and depression), neurodegenerative disorders (Parkinson's and Alzheimer's disease) and cancer. 19204725 2009
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.310 GeneticVariation disease LHGDN The vesicular monoamine transporter 1 gene (VMAT1/SLC18A1) maps to the shared bipolar disorder (BPD)/schizophrenia (SZ) susceptibility locus on chromosome 8p21. 16936705 2006
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.030 GeneticVariation disease BEFREE Association study of the vesicular monoamine transporter 1 (VMAT1) gene with autism in an Iranian population. 28476685 2017
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.030 GeneticVariation disease BEFREE The gene for solute carrier family 18 member A1 (vesicular monoamine transporter; SLC18A1) is of particular interest in this regard because of its association with schizophrenia, autism and bipolar illness as well as with cancer. 30194079 2018
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.020 GeneticVariation group BEFREE Molecular genetics and developmental studies have identified 21 genes in this region (ADRA1A, ARHGEF10, CHRNA2, CHRNA6, CHRNB3, DKK4, DPYSL2, EGR3, FGF17, FGF20, FGFR1, FZD3, LDL, NAT2, NEF3, NRG1, PCM1, PLAT, PPP3CC, SFRP1 and VMAT1/SLC18A1) that are most likely to contribute to neuropsychiatric disorders (schizophrenia, autism, bipolar disorder and depression), neurodegenerative disorders (Parkinson's and Alzheimer's disease) and cancer. 19204725 2009
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.020 GeneticVariation phenotype BEFREE Our results may contribute to the evidence indicating an association between the VMAT1 gene and structural brain alterations in depression. 28408293 2017
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.020 GeneticVariation phenotype BEFREE Molecular genetics and developmental studies have identified 21 genes in this region (ADRA1A, ARHGEF10, CHRNA2, CHRNA6, CHRNB3, DKK4, DPYSL2, EGR3, FGF17, FGF20, FGFR1, FZD3, LDL, NAT2, NEF3, NRG1, PCM1, PLAT, PPP3CC, SFRP1 and VMAT1/SLC18A1) that are most likely to contribute to neuropsychiatric disorders (schizophrenia, autism, bipolar disorder and depression), neurodegenerative disorders (Parkinson's and Alzheimer's disease) and cancer. 19204725 2009
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.020 GeneticVariation group BEFREE Molecular genetics and developmental studies have identified 21 genes in this region (ADRA1A, ARHGEF10, CHRNA2, CHRNA6, CHRNB3, DKK4, DPYSL2, EGR3, FGF17, FGF20, FGFR1, FZD3, LDL, NAT2, NEF3, NRG1, PCM1, PLAT, PPP3CC, SFRP1 and VMAT1/SLC18A1) that are most likely to contribute to neuropsychiatric disorders (schizophrenia, autism, bipolar disorder and depression), neurodegenerative disorders (Parkinson's and Alzheimer's disease) and cancer. 19204725 2009
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.010 GeneticVariation disease BEFREE Molecular genetics and developmental studies have identified 21 genes in this region (ADRA1A, ARHGEF10, CHRNA2, CHRNA6, CHRNB3, DKK4, DPYSL2, EGR3, FGF17, FGF20, FGFR1, FZD3, LDL, NAT2, NEF3, NRG1, PCM1, PLAT, PPP3CC, SFRP1 and VMAT1/SLC18A1) that are most likely to contribute to neuropsychiatric disorders (schizophrenia, autism, bipolar disorder and depression), neurodegenerative disorders (Parkinson's and Alzheimer's disease) and cancer. 19204725 2009
CUI: C0003125
Disease: Anorexia Nervosa
Anorexia Nervosa 		0.010 GeneticVariation disease BEFREE Following on from previous work by our group where we showed that early onset anorexia nervosa (AN) and obsessive-compulsive disorder (OCD) shared a common genetic background, the aim of the present study is to assess genetic pleiotropy related to the serotonergic system (SLC6A4, 5HTR2A, 5HTR2C, TPH2, SLC18A1), in a common phenotype such as very-early age of onset. 30554102 2019
CUI: C0006012
Disease: Borderline Personality Disorder
Borderline Personality Disorder 		0.010 GeneticVariation disease BEFREE Results suggest that variations in the VMAT1 gene may confer susceptibility to BPD in patients of European descent. 16936705 2006
CUI: C0006287
Disease: Bronchopulmonary Dysplasia
Bronchopulmonary Dysplasia 		0.010 GeneticVariation disease BEFREE Results suggest that variations in the VMAT1 gene may confer susceptibility to BPD in patients of European descent. 16936705 2006
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.010 GeneticVariation disease BEFREE In summary, the germline deletions at SLC18A1 contributed to the development of CRC. 28968818 2017
CUI: C0028768
Disease: Obsessive-Compulsive Disorder
Obsessive-Compulsive Disorder 		0.010 GeneticVariation disease BEFREE Following on from previous work by our group where we showed that early onset anorexia nervosa (AN) and obsessive-compulsive disorder (OCD) shared a common genetic background, the aim of the present study is to assess genetic pleiotropy related to the serotonergic system (SLC6A4, 5HTR2A, 5HTR2C, TPH2, SLC18A1), in a common phenotype such as very-early age of onset. 30554102 2019
CUI: C0236663
Disease: Alcohol withdrawal syndrome
Alcohol withdrawal syndrome 		0.010 GeneticVariation disease BEFREE This study shows that genetic variants in VMAT1, including the functional SNP rs1390938, contribute to the severity of AW in patients of European descent. 26876819 2016
CUI: C0524851
Disease: Neurodegenerative Disorders
Neurodegenerative Disorders 		0.010 GeneticVariation group BEFREE Molecular genetics and developmental studies have identified 21 genes in this region (ADRA1A, ARHGEF10, CHRNA2, CHRNA6, CHRNB3, DKK4, DPYSL2, EGR3, FGF17, FGF20, FGFR1, FZD3, LDL, NAT2, NEF3, NRG1, PCM1, PLAT, PPP3CC, SFRP1 and VMAT1/SLC18A1) that are most likely to contribute to neuropsychiatric disorders (schizophrenia, autism, bipolar disorder and depression), neurodegenerative disorders (Parkinson's and Alzheimer's disease) and cancer. 19204725 2009
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.010 GeneticVariation disease BEFREE Diffusion tensor imaging (DTI) and VMAT1 rs1390938" genes_norm="6570">Thr136Ile (rs1390938) genotyping were performed on 103 patients diagnosed with MDD and 83 healthy control participants. 28408293 2017