|
Schizophrenia
|
0.370 |
Biomarker
|
disease |
BEFREE |
We conclude that dopaminergic signaling is robustly altered in the frontal cortex of VMAT1 null-mutant mice and suggest that VMAT1 may be relevant to the pathogenesis and/or treatment of psychiatric illnesses including schizophrenia and bipolar disease.
|
30685272 |
2019 |
|
Schizophrenia
|
0.370 |
Biomarker
|
disease |
BEFREE |
The gene for solute carrier family 18 member A1 (vesicular monoamine transporter; SLC18A1) is of particular interest in this regard because of its association with schizophrenia, autism and bipolar illness as well as with cancer.
|
30194079 |
2018 |
|
Schizophrenia
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, several recent genetic case-control studies have documented an association between common missense variations in the VMAT1 gene and susceptibility to bipolar disorder and schizophrenia.
|
20419435 |
2010 |
|
Schizophrenia
|
0.370 |
Biomarker
|
disease |
BEFREE |
Molecular genetics and developmental studies have identified 21 genes in this region (ADRA1A, ARHGEF10, CHRNA2, CHRNA6, CHRNB3, DKK4, DPYSL2, EGR3, FGF17, FGF20, FGFR1, FZD3, LDL, NAT2, NEF3, NRG1, PCM1, PLAT, PPP3CC, SFRP1 and VMAT1/SLC18A1) that are most likely to contribute to neuropsychiatric disorders (schizophrenia, autism, bipolar disorder and depression), neurodegenerative disorders (Parkinson's and Alzheimer's disease) and cancer.
|
19204725 |
2009 |
|
Schizophrenia
|
0.370 |
GeneticVariation
|
disease |
LHGDN |
Variations in the VMAT1 gene might affect transporter function and/or expression, and might be involved in the etiology of SZ.
|
18451639 |
2008 |
|
Schizophrenia
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
The gene encoding the vesicular monoamine transporter 1 (VMAT1/SLC18A1) maps to chromosome 8p21, a region where several linkage peaks overlap between schizophrenia, bipolar disorder and anxiety-related personality traits.
|
18249496 |
2008 |
|
Schizophrenia
|
0.370 |
Biomarker
|
disease |
PSYGENET |
Variations in the VMAT1 gene might affect transporter function and/or expression, and might be involved in the etiology of SZ.
|
18451639 |
2008 |
|
Schizophrenia
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
Variations in the VMAT1 gene might affect transporter function and/or expression, and might be involved in the etiology of SZ.
|
18451639 |
2008 |
|
Schizophrenia
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
Variations in the VMAT1 gene might affect transporter function and/or expression and might be involved in the etiology of BPD and/or SZ.
|
16936705 |
2006 |
|
Mental Depression
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
Our results may contribute to the evidence indicating an association between the VMAT1 gene and structural brain alterations in depression.
|
28408293 |
2017 |
|
Depressive disorder
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
Our results may contribute to the evidence indicating an association between the VMAT1 gene and structural brain alterations in depression.
|
28408293 |
2017 |
|
Mental Depression
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
Molecular genetics and developmental studies have identified 21 genes in this region (ADRA1A, ARHGEF10, CHRNA2, CHRNA6, CHRNB3, DKK4, DPYSL2, EGR3, FGF17, FGF20, FGFR1, FZD3, LDL, NAT2, NEF3, NRG1, PCM1, PLAT, PPP3CC, SFRP1 and VMAT1/SLC18A1) that are most likely to contribute to neuropsychiatric disorders (schizophrenia, autism, bipolar disorder and depression), neurodegenerative disorders (Parkinson's and Alzheimer's disease) and cancer.
|
19204725 |
2009 |
|
Mental Depression
|
0.320 |
Biomarker
|
disease |
PSYGENET |
Molecular genetics and developmental studies have identified 21 genes in this region (ADRA1A, ARHGEF10, CHRNA2, CHRNA6, CHRNB3, DKK4, DPYSL2, EGR3, FGF17, FGF20, FGFR1, FZD3, LDL, NAT2, NEF3, NRG1, PCM1, PLAT, PPP3CC, SFRP1 and VMAT1/SLC18A1) that are most likely to contribute to neuropsychiatric disorders (schizophrenia, autism, bipolar disorder and depression), neurodegenerative disorders (Parkinson's and Alzheimer's disease) and cancer.
|
19204725 |
2009 |
|
Depressive disorder
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
Molecular genetics and developmental studies have identified 21 genes in this region (ADRA1A, ARHGEF10, CHRNA2, CHRNA6, CHRNB3, DKK4, DPYSL2, EGR3, FGF17, FGF20, FGFR1, FZD3, LDL, NAT2, NEF3, NRG1, PCM1, PLAT, PPP3CC, SFRP1 and VMAT1/SLC18A1) that are most likely to contribute to neuropsychiatric disorders (schizophrenia, autism, bipolar disorder and depression), neurodegenerative disorders (Parkinson's and Alzheimer's disease) and cancer.
|
19204725 |
2009 |
|
Depressive disorder
|
0.320 |
Biomarker
|
disease |
PSYGENET |
Molecular genetics and developmental studies have identified 21 genes in this region (ADRA1A, ARHGEF10, CHRNA2, CHRNA6, CHRNB3, DKK4, DPYSL2, EGR3, FGF17, FGF20, FGFR1, FZD3, LDL, NAT2, NEF3, NRG1, PCM1, PLAT, PPP3CC, SFRP1 and VMAT1/SLC18A1) that are most likely to contribute to neuropsychiatric disorders (schizophrenia, autism, bipolar disorder and depression), neurodegenerative disorders (Parkinson's and Alzheimer's disease) and cancer.
|
19204725 |
2009 |
|
Bipolar Disorder
|
0.310 |
Biomarker
|
disease |
PSYGENET |
Furthermore, several recent genetic case-control studies have documented an association between common missense variations in the VMAT1 gene and susceptibility to bipolar disorder and schizophrenia.
|
20419435 |
2010 |
|
Bipolar Disorder
|
0.310 |
Biomarker
|
disease |
PSYGENET |
Molecular genetics and developmental studies have identified 21 genes in this region (ADRA1A, ARHGEF10, CHRNA2, CHRNA6, CHRNB3, DKK4, DPYSL2, EGR3, FGF17, FGF20, FGFR1, FZD3, LDL, NAT2, NEF3, NRG1, PCM1, PLAT, PPP3CC, SFRP1 and VMAT1/SLC18A1) that are most likely to contribute to neuropsychiatric disorders (schizophrenia, autism, bipolar disorder and depression), neurodegenerative disorders (Parkinson's and Alzheimer's disease) and cancer.
|
19204725 |
2009 |
|
Bipolar Disorder
|
0.310 |
Biomarker
|
disease |
PSYGENET |
The gene encoding the vesicular monoamine transporter 1 (VMAT1/SLC18A1) maps to chromosome 8p21, a region where several linkage peaks overlap between schizophrenia, bipolar disorder and anxiety-related personality traits.
|
18249496 |
2008 |
|
Bipolar Disorder
|
0.310 |
Biomarker
|
disease |
BEFREE |
The vesicular monoamine transporter 1 gene (VMAT1/SLC18A1) maps to the shared bipolar disorder (BPD)/schizophrenia (SZ) susceptibility locus on chromosome 8p21.
|
16936705 |
2006 |
|
Bipolar Disorder
|
0.310 |
Biomarker
|
disease |
PSYGENET |
The vesicular monoamine transporter 1 gene (VMAT1/SLC18A1) maps to the shared bipolar disorder (BPD)/schizophrenia (SZ) susceptibility locus on chromosome 8p21.
|
16936705 |
2006 |
|
Bipolar Disorder
|
0.310 |
GeneticVariation
|
disease |
LHGDN |
The vesicular monoamine transporter 1 gene (VMAT1/SLC18A1) maps to the shared bipolar disorder (BPD)/schizophrenia (SZ) susceptibility locus on chromosome 8p21.
|
16936705 |
2006 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
In the Pan Cancer Atlas, increased expression of SLC18A1 places such a tumor in group C5, among immunologically-quiet tumors.
|
30194079 |
2018 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
In LCM samples, similar observations were obtained that the expression levels of SLC18A1 in the tumor buddings, cancer cells in the center of primary tumor, and stroma of both tumor budding and cancer cells were lower than normal intestinal epithelial and stromal cells (fold change = 0.17-0.62, 0.12-0.57 and 0.37-0.68, respectively).
|
28968818 |
2017 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
Immunohistochemical analysis revealed low expression of VMAT1 in the tumor compared to the normal, surrounding tissue.
|
25120831 |
2014 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Furthermore, double immunofluorescence studies explored the potential co-localization of the vesicular monoamine transporter 1 (SLC18A1, generally referred to as VMAT1) and OR51E1 in the neoplastic cells and in the intestinal mucosa adjacent to the tumor.
|
23184910 |
2013 |